Yanling Yang1, Fan Zhang2. 1. State Key Laboratory of Analytical Chemistry for Life Science, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China. 2. Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers and iChem, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai, 200433, China. zhang_fan@fudan.edu.cn.
Abstract
PURPOSE: This systematic review aims to summarize the current developments of fluorescence and chemi/bioluminescence imaging based on the molecular fluorophores for in vivo imaging in the second near-infrared window. METHODS AND RESULTS: By investigating most of the relevant references on the web of science and some journals, this review firstly begins with an overview of the background of fluorescence and chemi/bioluminescence imaging. Secondly, the chemical and optical properties of NIR-II dyes are discussed, such as water solubility, chemostability and photo-stability, and brightness. Thirdly, the bioimaging based on NIR-II fluorescence emission is outlined, including the in vivo imaging of polymethine dyes, donor - acceptor - donor (D - A - D) chromophores, and lanthanide complexes. Fourthly, we demonstrate the chemi/bioluminescence in vivo imaging in the second near-infrared window. Fifthly, the clinical application and translation of near-infrared fluorescence imaging are presented. Finally, the current challenges, feasible strategies and potential prospects of the fluorophores and in vivo bioimaging are discussed. CONCLUSIONS: Based on the above literature research on the applications of molecular fluorescent and chemi/bioluminescent probes in the second near-infrared window in recent years, this review weighs the advantages and disadvantages of fluorescence and chemi/bioluminescence imaging, and NIR-II fluorophores based on polymethine dyes, D - A - D chromophores, and lanthanide complexes. Besides, this review also provides a very important guidance for expanding the imaging applications of molecular fluorophores in the second near-infrared window.
PURPOSE: This systematic review aims to summarize the current developments of fluorescence and chemi/bioluminescence imaging based on the molecular fluorophores for in vivo imaging in the second near-infrared window. METHODS AND RESULTS: By investigating most of the relevant references on the web of science and some journals, this review firstly begins with an overview of the background of fluorescence and chemi/bioluminescence imaging. Secondly, the chemical and optical properties of NIR-II dyes are discussed, such as water solubility, chemostability and photo-stability, and brightness. Thirdly, the bioimaging based on NIR-II fluorescence emission is outlined, including the in vivo imaging of polymethine dyes, donor - acceptor - donor (D - A - D) chromophores, and lanthanide complexes. Fourthly, we demonstrate the chemi/bioluminescence in vivo imaging in the second near-infrared window. Fifthly, the clinical application and translation of near-infrared fluorescence imaging are presented. Finally, the current challenges, feasible strategies and potential prospects of the fluorophores and in vivo bioimaging are discussed. CONCLUSIONS: Based on the above literature research on the applications of molecular fluorescent and chemi/bioluminescent probes in the second near-infrared window in recent years, this review weighs the advantages and disadvantages of fluorescence and chemi/bioluminescence imaging, and NIR-II fluorophores based on polymethine dyes, D - A - D chromophores, and lanthanide complexes. Besides, this review also provides a very important guidance for expanding the imaging applications of molecular fluorophores in the second near-infrared window.
Authors: Min Hao Wong; Juan P Giraldo; Seon-Yeong Kwak; Volodymyr B Koman; Rosalie Sinclair; Tedrick Thomas Salim Lew; Gili Bisker; Pingwei Liu; Michael S Strano Journal: Nat Mater Date: 2016-10-31 Impact factor: 43.841
Authors: Ji-Ho Park; Luo Gu; Geoffrey von Maltzahn; Erkki Ruoslahti; Sangeeta N Bhatia; Michael J Sailor Journal: Nat Mater Date: 2009-02-22 Impact factor: 43.841
Authors: Alexander L Antaris; Hao Chen; Kai Cheng; Yao Sun; Guosong Hong; Chunrong Qu; Shuo Diao; Zixin Deng; Xianming Hu; Bo Zhang; Xiaodong Zhang; Omar K Yaghi; Zita R Alamparambil; Xuechuan Hong; Zhen Cheng; Hongjie Dai Journal: Nat Mater Date: 2015-11-23 Impact factor: 43.841
Authors: Debadyuti Ghosh; Alexander F Bagley; Young Jeong Na; Michael J Birrer; Sangeeta N Bhatia; Angela M Belcher Journal: Proc Natl Acad Sci U S A Date: 2014-09-11 Impact factor: 11.205
Authors: D J Naczynski; M C Tan; M Zevon; B Wall; J Kohl; A Kulesa; S Chen; C M Roth; R E Riman; P V Moghe Journal: Nat Commun Date: 2013 Impact factor: 14.919
Authors: Nicole M Iverson; Paul W Barone; Mia Shandell; Laura J Trudel; Selda Sen; Fatih Sen; Vsevolod Ivanov; Esha Atolia; Edgardo Farias; Thomas P McNicholas; Nigel Reuel; Nicola M A Parry; Gerald N Wogan; Michael S Strano Journal: Nat Nanotechnol Date: 2013-11-03 Impact factor: 39.213
Authors: P S Russell; R Velivolu; V E Maldonado Zimbrón; J Hong; I Kavianinia; A J R Hickey; J A Windsor; A R J Phillips Journal: Front Pharmacol Date: 2022-07-22 Impact factor: 5.988