| Literature DB >> 35084939 |
Ethan A Winkler1,2,3,4, Chang N Kim2,3,5,6, Jayden M Ross1,2,3,5,6, Joseph H Garcia1, Eugene Gil1,2, Irene Oh7, Lindsay Q Chen7, David Wu1,2, Joshua S Catapano4, Kunal Raygor1, Kazim Narsinh8, Helen Kim9, Shantel Weinsheimer9, Daniel L Cooke3,8, Brian P Walcott10, Michael T Lawton4, Nalin Gupta1, Berislav V Zlokovic11,12, Edward F Chang1,3, Adib A Abla1,3, Daniel A Lim1,2,3,13, Tomasz J Nowakowski1,2,3,5,6,14.
Abstract
Cerebrovascular diseases are a leading cause of death and neurologic disability. Further understanding of disease mechanisms and therapeutic strategies requires a deeper knowledge of cerebrovascular cells in humans. We profiled transcriptomes of 181,388 cells to define a cell atlas of the adult human cerebrovasculature, including endothelial cell molecular signatures with arteriovenous segmentation and expanded perivascular cell diversity. By leveraging this reference, we investigated cellular and molecular perturbations in brain arteriovenous malformations, which are a leading cause of stroke in young people, and identified pathologic endothelial transformations with abnormal vascular patterning and the ontology of vascularly derived inflammation. We illustrate the interplay between vascular and immune cells that contributes to brain hemorrhage and catalog opportunities for targeting angiogenic and inflammatory programs in vascular malformations.Entities:
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Year: 2022 PMID： 35084939 PMCID： PMC8995178 DOI： 10.1126/science.abi7377
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 63.714