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Literature DB >> 350728

Immunohistochemical localisation of urogastrone to human duodenal and submandibular glands.

P U Heitz, M Kasper, S van Noorden, J M Polak, H Gregory, A G Pearse.

Abstract

Urogastrone has been localised by immunostaining to granules of the cells of human duodenal (Brunner's) glands and their ducts and of acinar cells in the human submandibular gland. The immunoreactive peptide is present in large quantities in duodenal glands and their secretory ducts. Urogastrone or human epidermal growth factor promotes cellular proliferation in vivo as well as in vitro and inhibits gastric acid secretion and may, therefore, be one of the duodenal factors inhibiting gastric activity. Thus it may have an important regulatory and protective function for the intestinal mucosa and may possibly become a useful therapeutic agent.

Entities: Gene Species

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Year: 1978 PMID： 350728 PMCID： PMC1412104 DOI： 10.1136/gut.19.5.408

Source DB: PubMed Journal: Gut ISSN： 0017-5749 Impact factor: 23.059

20 in total

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Journal: Gut Date: 1975-11 Impact factor: 23.059

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Authors: H Gregory; J E Holmes; I R Willshire
Journal: J Clin Endocrinol Metab Date: 1977-10 Impact factor: 5.958

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Journal: Br J Surg Date: 1976-08 Impact factor: 6.939

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Authors: J B Elder; I E Gillespie; P C Ganguli; W I Delamore; H Gregory
Journal: Lancet Date: 1975-09-06 Impact factor: 79.321

9. Human urogastrone and mouse epidermal growth factor share a common receptor site in cultured human fibroblasts.

Authors: M D Hollenberg; H Gregory
Journal: Life Sci Date: 1977-01-15 Impact factor: 5.037

10. Mouse epidermal growth factor: light and electron microscopical localisation by immunocytochemical staining.

Authors: S Van Noorden; P Heitz; M Kasper; A G Pearse
Journal: Histochemistry Date: 1977-06-24

45 in total

1. Epidermal growth factor receptor inhibits colitis-associated cancer in mice.

Authors: Philip E Dubé; Fang Yan; Shivesh Punit; Nandini Girish; Steven J McElroy; M Kay Washington; D Brent Polk
Journal: J Clin Invest Date: 2012-07-09 Impact factor: 14.808

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Authors: R J Playford; N A Wright
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Authors: Katherine M DiGuilio; Christina M Mercogliano; Jillian Born; Brendan Ferraro; Julie To; Brittany Mixson; Allison Smith; Mary Carmen Valenzano; James M Mullin
Journal: World J Gastrointest Pathophysiol Date: 2016-05-15

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Authors: Kathryn J Rowland; Pamela M Choi; Brad W Warner
Journal: Semin Pediatr Surg Date: 2013-05 Impact factor: 2.754

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Authors: J P Hong; S-W Lee; S Y Song; S D Ahn; S S Shin; E K Choi; J H Kim
Journal: Eur J Cancer Care (Engl) Date: 2009-04-23 Impact factor: 2.520