Literature DB >> 35063069

The loud minority: Transcriptionally active HIV-1-infected cells survive, proliferate, and persist.

Jack A Collora1, Ya-Chi Ho2.   

Abstract

The shock-and-kill strategy reactivates HIV-1 latent reservoir for immune clearance. Einkauf et al. found that some HIV-1-infected cells that persist and proliferate have transcriptionally active HIV-1 in permissive chromatin. Silent proviruses in repressive chromatin resist reactivation. Understanding HIV-1-chromatin interactions and how transcriptionally active HIV-1-infected cells survive is a pressing need.
Copyright © 2021 Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2022        PMID： 35063069      PMCID： PMC9195179          DOI： 10.1016/j.cell.2021.12.038

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   66.850


  10 in total

1.  Defective HIV-1 Proviruses Are Expressed and Can Be Recognized by Cytotoxic T Lymphocytes, which Shape the Proviral Landscape.

Authors:  Ross A Pollack; R Brad Jones; Mihaela Pertea; Katherine M Bruner; Alyssa R Martin; Allison S Thomas; Adam A Capoferri; Subul A Beg; Szu-Han Huang; Sara Karandish; Haiping Hao; Eitan Halper-Stromberg; Patrick C Yong; Colin Kovacs; Erika Benko; Robert F Siliciano; Ya-Chi Ho
Journal:  Cell Host Microbe       Date:  2017-04-12       Impact factor: 21.023

2.  Position effects influence HIV latency reversal.

Authors:  Heng-Chang Chen; Javier P Martinez; Eduard Zorita; Andreas Meyerhans; Guillaume J Filion
Journal:  Nat Struct Mol Biol       Date:  2016-11-21       Impact factor: 15.369

3.  Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy.

Authors:  Kevin B Einkauf; Guinevere Q Lee; Ce Gao; Radwa Sharaf; Xiaoming Sun; Stephane Hua; Samantha My Chen; Chenyang Jiang; Xiaodong Lian; Fatema Z Chowdhury; Eric S Rosenberg; Tae-Wook Chun; Jonathan Z Li; Xu G Yu; Mathias Lichterfeld
Journal:  J Clin Invest       Date:  2019-01-28       Impact factor: 14.808

4.  Combined HIV-1 sequence and integration site analysis informs viral dynamics and allows reconstruction of replicating viral ancestors.

Authors:  Sean C Patro; Leah D Brandt; Michael J Bale; Elias K Halvas; Kevin W Joseph; Wei Shao; Xiaolin Wu; Shuang Guo; Ben Murrell; Ann Wiegand; Jonathan Spindler; Castle Raley; Christopher Hautman; Michele Sobolewski; Christine M Fennessey; Wei-Shau Hu; Brian Luke; Jenna M Hasson; Aurelie Niyongabo; Adam A Capoferri; Brandon F Keele; Jeff Milush; Rebecca Hoh; Steven G Deeks; Frank Maldarelli; Stephen H Hughes; John M Coffin; Jason W Rausch; John W Mellors; Mary F Kearney
Journal:  Proc Natl Acad Sci U S A       Date:  2019-11-27       Impact factor: 11.205

5.  Single-cell transcriptional landscapes reveal HIV-1-driven aberrant host gene transcription as a potential therapeutic target.

Authors:  Runxia Liu; Yang-Hui Jimmy Yeh; Ales Varabyou; Jack A Collora; Scott Sherrill-Mix; C Conover Talbot; Sameet Mehta; Kristen Albrecht; Haiping Hao; Hao Zhang; Ross A Pollack; Subul A Beg; Rachela M Calvi; Jianfei Hu; Christine M Durand; Richard F Ambinder; Rebecca Hoh; Steven G Deeks; Jennifer Chiarella; Serena Spudich; Daniel C Douek; Frederic D Bushman; Mihaela Pertea; Ya-Chi Ho
Journal:  Sci Transl Med       Date:  2020-05-13       Impact factor: 17.956

6.  HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells.

Authors:  F Maldarelli; X Wu; L Su; F R Simonetti; W Shao; S Hill; J Spindler; A L Ferris; J W Mellors; M F Kearney; J M Coffin; S H Hughes
Journal:  Science       Date:  2014-06-26       Impact factor: 47.728

7.  HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection.

Authors:  Thor A Wagner; Sherry McLaughlin; Kavita Garg; Charles Y K Cheung; Brendan B Larsen; Sheila Styrchak; Hannah C Huang; Paul T Edlefsen; James I Mullins; Lisa M Frenkel
Journal:  Science       Date:  2014-07-10       Impact factor: 47.728

8.  Parallel analysis of transcription, integration, and sequence of single HIV-1 proviruses.

Authors:  Kevin B Einkauf; Matthew R Osborn; Ce Gao; Weiwei Sun; Xiaoming Sun; Xiaodong Lian; Elizabeth M Parsons; Gregory T Gladkov; Kyra W Seiger; Jane E Blackmer; Chenyang Jiang; Steven A Yukl; Eric S Rosenberg; Xu G Yu; Mathias Lichterfeld
Journal:  Cell       Date:  2022-01-12       Impact factor: 41.582

9.  Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration.

Authors:  Bojana Lucic; Heng-Chang Chen; Maja Kuzman; Eduard Zorita; Julia Wegner; Vera Minneker; Wei Wang; Raffaele Fronza; Stefanie Laufs; Manfred Schmidt; Ralph Stadhouders; Vassilis Roukos; Kristian Vlahovicek; Guillaume J Filion; Marina Lusic
Journal:  Nat Commun       Date:  2019-09-06       Impact factor: 14.919

10.  Distinct viral reservoirs in individuals with spontaneous control of HIV-1.

Authors:  Chenyang Jiang; Xiaodong Lian; Ce Gao; Xiaoming Sun; Kevin B Einkauf; Joshua M Chevalier; Samantha M Y Chen; Stephane Hua; Ben Rhee; Kaylee Chang; Jane E Blackmer; Matthew Osborn; Michael J Peluso; Rebecca Hoh; Ma Somsouk; Jeffrey Milush; Lynn N Bertagnolli; Sarah E Sweet; Joseph A Varriale; Peter D Burbelo; Tae-Wook Chun; Gregory M Laird; Erik Serrao; Alan N Engelman; Mary Carrington; Robert F Siliciano; Janet M Siliciano; Steven G Deeks; Bruce D Walker; Mathias Lichterfeld; Xu G Yu
Journal:  Nature       Date:  2020-08-26       Impact factor: 69.504
  10 in total
  1 in total

Review 1.  An ordeal that does not heal: understanding barriers to a cure for HIV-1 infection.

Authors:  Mathias Lichterfeld; Ce Gao; Xu G Yu
Journal:  Trends Immunol       Date:  2022-08       Impact factor: 19.709
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.