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Literature DB >> 35059897

Critical pathways of oral squamous cell carcinoma: molecular biomarker and therapeutic intervention.

Sharmistha Dey¹, Abhay Kumar Singh², Abhinay Kumar Singh³, Kartik Rawat³, Joyita Banerjee⁴, Vertica Agnihotri³, Deepak Upadhaya³.

Abstract

The rapid growth of oral cancer is a significant concern, especially in developing countries due to the advanced lifestyle and 5-year survival despite advanced multimodality of cancer care. The poor modality might be due to the detection of disease in the advanced stage. Early detection and development of novel therapies can improve oral cancer patient survival. The PI3K/AKT/mTOR and RAS-RAF-MEK-ERK are very extensively exploited pathways in oral cancer. These pathways are very critical in the progression of tumorigenesis in oral cancer. This review focuses on the association of Ras/Raf/MEK/ERK and PI3K/AKT/mTOR pathways in terms of protein expression level, genetic mutation, and therapeutic intervention in oral cancer.

Entities: Chemical

Keywords: Biomarker; Oral cancer; PI3K/AKT/mTOR; Ras/Raf/MEK/ERK; Therapeutic

Mesh：

Substances：

Year: 2022 PMID： 35059897 DOI： 10.1007/s12032-021-01633-4

Source DB: PubMed Journal: Med Oncol ISSN： 1357-0560 Impact factor: 3.064

91 in total

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Authors: Juan C Cuevas Gonzalez; Luis A Gaitan Cepeda; Socorro A Borges Yanez; Alejandro Donohue Cornejo; Ana D Mori Estevez; Elba Rosa Leyva Huerta
Journal: Indian J Pathol Microbiol Date: 2016 Apr-Jun Impact factor: 0.740

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Authors: M Maekawa; T Ishizaki; S Boku; N Watanabe; A Fujita; A Iwamatsu; T Obinata; K Ohashi; K Mizuno; S Narumiya
Journal: Science Date: 1999-08-06 Impact factor: 47.728

4. The mutational landscape of head and neck squamous cell carcinoma.

Authors: Nicolas Stransky; Ann Marie Egloff; Aaron D Tward; Aleksandar D Kostic; Kristian Cibulskis; Andrey Sivachenko; Gregory V Kryukov; Michael S Lawrence; Carrie Sougnez; Aaron McKenna; Erica Shefler; Alex H Ramos; Petar Stojanov; Scott L Carter; Douglas Voet; Maria L Cortés; Daniel Auclair; Michael F Berger; Gordon Saksena; Candace Guiducci; Robert C Onofrio; Melissa Parkin; Marjorie Romkes; Joel L Weissfeld; Raja R Seethala; Lin Wang; Claudia Rangel-Escareño; Juan Carlos Fernandez-Lopez; Alfredo Hidalgo-Miranda; Jorge Melendez-Zajgla; Wendy Winckler; Kristin Ardlie; Stacey B Gabriel; Matthew Meyerson; Eric S Lander; Gad Getz; Todd R Golub; Levi A Garraway; Jennifer R Grandis
Journal: Science Date: 2011-07-28 Impact factor: 47.728

Review 5. Epidermal growth factor receptor targeted therapy of squamous cell carcinoma of the head and neck.

Authors: Mark E Sharafinski; Robert L Ferris; Soldano Ferrone; Jennifer R Grandis
Journal: Head Neck Date: 2010-10 Impact factor: 3.147

6. Persistent activation of Rac1 in squamous carcinomas of the head and neck: evidence for an EGFR/Vav2 signaling axis involved in cell invasion.

Authors: Vyomesh Patel; Hans M Rosenfeldt; Ruth Lyons; Joan-Marc Servitja; Xosé R Bustelo; Mary Siroff; J Silvio Gutkind
Journal: Carcinogenesis Date: 2007-01-18 Impact factor: 4.944

Critical pathways of oral squamous cell carcinoma: molecular biomarker and therapeutic intervention.

Review 1. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.

2. p53 and p16 in oral epithelial dysplasia and oral squamous cell carcinoma: A study of 208 cases.

3. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.

4. The mutational landscape of head and neck squamous cell carcinoma.

Review 5. Epidermal growth factor receptor targeted therapy of squamous cell carcinoma of the head and neck.

6. Persistent activation of Rac1 in squamous carcinomas of the head and neck: evidence for an EGFR/Vav2 signaling axis involved in cell invasion.

7. Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01.

8. FAT1 somatic mutations in head and neck carcinoma are associated with tumor progression and survival.

Review 9. Changing Trends in oral cancer - a global scenario.

10. Identiﬁcation of Key Genes and Pathways in Tongue Squamous Cell Carcinoma Using Bioinformatics Analysis.

1. p-S6 as a Prognostic Biomarker in Canine Oral Squamous Cell Carcinoma.