BACKGROUND: The compatibility of deep brain stimulation (DBS) hardware and MRI scans has greatly improved the diagnostic rate of postoperative peri-lead edema (PLE). However, the etiology, incidence, and prognostic outcomes of this complication have not been established. OBJECTIVE: The incidence of PLE and associated symptoms, the process of occurrence and progression of this complication, as well as treatment strategies were evaluated. METHODS: We conducted a Preferred Reporting Items for Systematic Reviews and Meta-Analyses compliant systematic review of all studies that reported on incidences of PLE and associated symptoms after DBS implantation. Through systematic literature review, we evaluated its causes, neuropsychiatric symptoms, duration, treatment methods, and prognostic outcomes. RESULTS: Our search retrieved 10 articles, including 5 articles on PLE and 10 articles on symptomatic PLE. The incidence of PLE was 35.8% (95% CI: 17.0%-54.6%), while the incidence of symptomatic PLE was 3.1% (95% CI: 1.5%-4.7%) accounting for 8.7% of PLE. CONCLUSIONS: This complication is not as rare as previously reported. Therefore, it requires significant attention after DBS implantation. The correlation between its causes, duration, symptoms, and the area involved in edema should be assessed in long-term prospective clinical studies with large sample sizes.
BACKGROUND: The compatibility of deep brain stimulation (DBS) hardware and MRI scans has greatly improved the diagnostic rate of postoperative peri-lead edema (PLE). However, the etiology, incidence, and prognostic outcomes of this complication have not been established. OBJECTIVE: The incidence of PLE and associated symptoms, the process of occurrence and progression of this complication, as well as treatment strategies were evaluated. METHODS: We conducted a Preferred Reporting Items for Systematic Reviews and Meta-Analyses compliant systematic review of all studies that reported on incidences of PLE and associated symptoms after DBS implantation. Through systematic literature review, we evaluated its causes, neuropsychiatric symptoms, duration, treatment methods, and prognostic outcomes. RESULTS: Our search retrieved 10 articles, including 5 articles on PLE and 10 articles on symptomatic PLE. The incidence of PLE was 35.8% (95% CI: 17.0%-54.6%), while the incidence of symptomatic PLE was 3.1% (95% CI: 1.5%-4.7%) accounting for 8.7% of PLE. CONCLUSIONS: This complication is not as rare as previously reported. Therefore, it requires significant attention after DBS implantation. The correlation between its causes, duration, symptoms, and the area involved in edema should be assessed in long-term prospective clinical studies with large sample sizes.
Authors: Jonathan Jagid; Karthik Madhavan; Amade Bregy; Mehul Desai; Armando Ruiz; Robert Quencer; Howard J Landy Journal: BMJ Case Rep Date: 2015-10-16
Authors: Mark J Nolt; Rajeev S Polasani; Taras W Masnyk; Michael Rezak; Joshua M Rosenow Journal: Stereotact Funct Neurosurg Date: 2020-11-20 Impact factor: 1.875
Authors: Catherine M K E de Cuba; Alberto Albanese; Angelo Antonini; Giovanni Cossu; Günther Deuschl; Roberto Eleopra; Alejandro Galati; Carel F E Hoffmann; Karina Knudsen; Andrea Landi; Michele Maria R Lanotte; Andrea Marcante; Arne Mosch; Manuela Pilleri; Martin M Reich; Valeria Ricchi; Sara Rinaldo; Luigi M Romito; Felipe S Saba; Horacio E Sacristan; P Richard Schuurman; Andrea Trezza; Pepijn van den Munckhof; Jens Volkmann; Maurizio Zibetti; Maria Fiorella Contarino Journal: Parkinsonism Relat Disord Date: 2016-09-06 Impact factor: 4.891