Yanhong Liu1,2, Di Luo1, Enzhao Liu1, Tong Liu1, Gang Xu1, Xue Liang1, Meng Yuan1, Yue Zhang1, Xinpei Chen1, Xu Chen1, Shuai Miao1, Wenfeng Shangguan1, Guangping Li3. 1. Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, the Second Hospital of Tianjin Medical University, Tianjin, 300211, China. 2. Heart Center, Tianjin Third Central Hospital,Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Artificial Cell Engineering Technology Research Center, Tianjin Institute of Hepatobiliary Disease, Tianjin, China. 3. Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, the Second Hospital of Tianjin Medical University, Tianjin, 300211, China. tic_tjcardiol@126.com.
Abstract
PURPOSE: The recurrence of atrial fibrillation (AF) after cryoablation still needs to be prioritized, including discriminating predictive indicators. METHODS: Eighty-seven patients aged 43-83 years who underwent cryo-balloon ablation were divided into paroxysmal atrial fibrillation (PAF) and non-paroxysmal atrial fibrillation (non-PAF) groups. Baseline data, intraoperative index, and miRNA21, IL-18, NLRP3, and visfatin levels in peripheral venous blood and left atrial blood were assessed. Follow-up was performed for 6 months to observe the recurrence of AF. A Cox risk ratio model was used to analyze indicators for predicting AF recurrence. RESULTS: The non-PAF and PAF group recurrence rates of AF were statistically different (p < 0.05) at 9/22 (40.9%) and 11/65 (16.9%), respectively. Biomarker levels in the left atrial blood were higher in the non-PAF group than in the PAF group (p < 0.05). The effects of non-PAF and levels of miRNA21 and IL-18 in left atrial serum on the recurrence of AF after cryoablation statistically differed (p < 0.05). CONCLUSION: The levels of miRNA21 and IL-18 were higher in left atrial blood than in peripheral blood, which may be related to the severity of AF and recurrence of AF after cryoablation.
PURPOSE: The recurrence of atrial fibrillation (AF) after cryoablation still needs to be prioritized, including discriminating predictive indicators. METHODS: Eighty-seven patients aged 43-83 years who underwent cryo-balloon ablation were divided into paroxysmal atrial fibrillation (PAF) and non-paroxysmal atrial fibrillation (non-PAF) groups. Baseline data, intraoperative index, and miRNA21, IL-18, NLRP3, and visfatin levels in peripheral venous blood and left atrial blood were assessed. Follow-up was performed for 6 months to observe the recurrence of AF. A Cox risk ratio model was used to analyze indicators for predicting AF recurrence. RESULTS: The non-PAF and PAF group recurrence rates of AF were statistically different (p < 0.05) at 9/22 (40.9%) and 11/65 (16.9%), respectively. Biomarker levels in the left atrial blood were higher in the non-PAF group than in the PAF group (p < 0.05). The effects of non-PAF and levels of miRNA21 and IL-18 in left atrial serum on the recurrence of AF after cryoablation statistically differed (p < 0.05). CONCLUSION: The levels of miRNA21 and IL-18 were higher in left atrial blood than in peripheral blood, which may be related to the severity of AF and recurrence of AF after cryoablation.
Authors: Yaniv Bar-Cohen; Michael J Silka; Allison C Hill; Jay D Pruetz; Ramen H Chmait; Li Zhou; Sara M Rabin; Viktoria Norekyan; Gerald E Loeb Journal: Circ Arrhythm Electrophysiol Date: 2018-07
Authors: Jan-Thorben Sieweke; Tobias Jonathan Pfeffer; Saskia Biber; Shambhabi Chatterjee; Karin Weissenborn; Gerrit M Grosse; Jan Hagemus; Anselm A Derda; Dominik Berliner; Ralf Lichtinghagen; Denise Hilfiker-Kleiner; Johann Bauersachs; Christian Bär; Thomas Thum; Udo Bavendiek Journal: J Clin Med Date: 2020-04-14 Impact factor: 4.241