UV-Curable Surface-Attached Antimicrobial Polymeric Onium Coatings: Designing Effective, Solvent-Resistant Coatings for Plastic Surfaces.

Contact-active ammonium and phosphonium antimicrobial polymeric coatings grafted to plastic surfaces by UV treatment are described. Robust, antimicrobial styrenic polymeric scaffolds copolymerized with a low loading of UV-curable benzophenone were prepared by nitroxide-mediated polymerization (NMP). Similar reversible addition-fragmentation chain-transfer (RAFT)-controlled radical polymerizations were attempted for comparison. These random styrenics were further functionalized into partially quaternarized water-soluble cationic polymers. UV-cured polymeric thin film coatings possessing cationic groups with n-alkyl substituents of n ≤ 2 demonstrate antimicrobial properties against both Gram-positive and Gram-negative bacteria, while species containing bulkier or longer substituents were biologically inactive. The UV-cured cationic antimicrobial polymeric onium thin films also demonstrate enhanced abrasion and chemical resistance.