Deep Learning-Based Parameter Mapping with Uncertainty Estimation for Fat Quantification using Accelerated Free-Breathing Radial MRI.

Deep learning has been applied to remove artifacts from undersampled MRI and to replace time-consuming signal fitting in quantitative MRI, but these have usually been treated as separate tasks, which does not fully exploit the shared information. This work proposes a new two-stage framework that completes these two tasks in a concerted approach and also estimates the pixel-wise uncertainty levels. Results from accelerated free-breathing radial MRI for liver fat quantification demonstrate that the proposed framework can achieve high image quality from undersampled radial data, high accuracy for liver fat quantification, and detect uncertainty caused by noisy input data. The proposed framework achieved 3-fold acceleration to <1 min scan time and reduced the computational time for signal fitting to <100 ms/slice in free-breathing liver fat quantification.