Literature DB >> 35021055

Analysis of antibody binding specificities in twin and SNP-genotyped cohorts reveals that antiviral antibody epitope selection is a heritable trait.

Thiagarajan Venkataraman1, Cristian Valencia2, Massimo Mangino3, William Morgenlander1, Steven J Clipman4, Thomas Liechti5, Ana Valencia6, Paraskevi Christofidou7, Tim Spector7, Mario Roederer5, Priya Duggal8, H Benjamin Larman9.   

Abstract

Human immune responses to viral infections are highly variable, but the genetic factors that contribute to this variability are not well characterized. We used VirScan, a high-throughput epitope scanning technology, to analyze pan-viral antibody reactivity profiles of twins and SNP-genotyped individuals. Using these data, we determined the heritability and genomic loci associated with antibody epitope selection, response breadth, and control of Epstein-Barr virus (EBV) viral load. 107 EBV peptide reactivities were heritable and at least two Epstein-Barr nuclear antigen 2 (EBNA-2) reactivities were associated with variants in the MHC class II locus. We identified an EBV serosignature that predicted viral load in peripheral blood mononuclear cells and was associated with variants in the MHC class I locus. Our study illustrates the utility of epitope profiling to investigate the genetics of pathogen immunity, reports heritable features of the antibody response to viruses, and identifies specific HLA loci important for EBV epitope selection.
Copyright © 2021 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Epstein-Barr virus; VirScan; humoral immunity; immunogenetics; viral antibody epitope selection

Mesh：

Substances：

Year:  2022        PMID： 35021055      PMCID： PMC8852220          DOI： 10.1016/j.immuni.2021.12.004

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   43.474


  65 in total

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Review 7.  The Individual and Population Genetics of Antibody Immunity.

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Authors:  Rohina Rubicz; Robert Yolken; Eugene Drigalenko; Melanie A Carless; Thomas D Dyer; Lara Bauman; Phillip E Melton; Jack W Kent; John B Harley; Joanne E Curran; Matthew P Johnson; Shelley A Cole; Laura Almasy; Eric K Moses; Nikhil V Dhurandhar; Ellen Kraig; John Blangero; Charles T Leach; Harald H H Göring
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Journal:  Science       Date:  2020-09-29       Impact factor: 63.714
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4.  Detecting antibody reactivities in Phage ImmunoPrecipitation Sequencing data.

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