Literature DB >> 3502083

Interleukin-1-production by monocytes from patients with systemic lupus erythematosus.

S Sierakowski1, E J Kucharz, R W Lightfoot, J S Goodwin.   

Abstract

Production of interleukin-1 (IL-1) by glass-adherent monocytes from 18 patients with systemic lupus erythematosus (SLE) was measured. Patients were divided into three groups according to disease activity. A deficient production of IL-1 was found in monocytes of SLE patients both without stimulation and after stimulation with 5 micrograms of lipopolysaccharide. The decreased production correlated with the degree of disease. Addition of phorbol myristate acetate to monocytes caused only partial normalization of the decreased IL-1 production. The IL-1 deficiency in SLE is postulated to be a part of complex abnormalities of cell-mediated immunity in this disease.

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Year:  1987        PMID： 3502083     DOI： 10.1007/BF02206840

Source DB:  PubMed          Journal:  Clin Rheumatol        ISSN： 0770-3198            Impact factor:   2.980


  25 in total

1.  Characterization of lymphocyte-activating factor (LAF) produced by the macrophage cell line, P388D1. I. Enhancement of LAF production by activated T lymphocytes.

Authors:  S B Mizel; J J Oppenheim; D L Rosenstreich
Journal:  J Immunol       Date:  1978-05       Impact factor: 5.422

2.  Abnormalities of delayed hypersensitivity in systemic lupus erythematosus.

Authors:  B H Hahn; K K Bagby; C K Osterland
Journal:  Am J Med       Date:  1973-07       Impact factor: 4.965

3.  Defective production of leucocytic endogenous mediator (interleukin 1) by peripheral blood leucocytes of patients with systemic sclerosis, systemic lupus erythematosus, rheumatoid arthritis and mixed connective tissue disease.

Authors:  J T Whicher; A M Gilbert; C Westacott; C Hutton; P A Dieppe
Journal:  Clin Exp Immunol       Date:  1986-07       Impact factor: 4.330

4.  Murine NK cell cultures: effects of interleukin-2 and interferon on cell growth and cytotoxic reactivity.

Authors:  K Kuribayashi; S Gillis; D E Kern; C S Henney
Journal:  J Immunol       Date:  1981-06       Impact factor: 5.422

5.  Relationship of cell cycle to recovery of IL 2 activity from human mononuclear cells, human and mouse T cell lines.

Authors:  B M Stadler; S F Dougherty; J J Farrar; J J Oppenheim
Journal:  J Immunol       Date:  1981-11       Impact factor: 5.422

6.  Interleukin 2 deficiencies in rheumatoid arthritis and systemic lupus erythematosus.

Authors:  N Miyasaka; T Nakamura; I J Russell; N Talal
Journal:  Clin Immunol Immunopathol       Date:  1984-04

7.  Lymphokines in autoimmunity: relationship between interleukin-2 and interferon-gamma production in systemic lupus erythematosus.

Authors:  W L Sibbitt; C Kenny; C W Spellman; K D Ley; A D Bankhurst
Journal:  Clin Immunol Immunopathol       Date:  1984-08

8.  Defective monocyte production of, and T lymphocyte response to, interleukin-1 in the peripheral blood of patients with systemic lupus erythematosus.

Authors:  J Alcocer-Varela; A Laffon; D Alarcón-Segovia
Journal:  Clin Exp Immunol       Date:  1984-01       Impact factor: 4.330

9.  T cell function in systemic lupus erythematosus: normal production of and responsiveness to interleukin 2.

Authors:  A M Draeger; A J Swaak; H G van den Brink; L A Aarden
Journal:  Clin Exp Immunol       Date:  1986-04       Impact factor: 4.330

10.  Characterization of T lymphocyte subpopulations responsible for deficient interleukin 2 activity in patients with systemic lupus erythematosus.

Authors:  Y Murakawa; S Takada; Y Ueda; N Suzuki; T Hoshino; T Sakane
Journal:  J Immunol       Date:  1985-01       Impact factor: 5.422
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  3 in total

Review 1.  The cytokine network in the pathogenesis of systemic lupus erythematosus and possible therapeutic implications.

Authors:  D A Horwitz; C O Jacob
Journal:  Springer Semin Immunopathol       Date:  1994

2.  Reduced expression of C1q-mRNA in monocytes from patients with systemic lupus erythematosus.

Authors:  F Moosig; F Damm; A Knorr-Spahr; M Ritgen; R A Zeuner; M Kneba; M Ernst; J O Schröder
Journal:  Clin Exp Immunol       Date:  2006-12       Impact factor: 4.330

Review 3.  Interleukin-1 Beta-A Friend or Foe in Malignancies?

Authors:  Rebekka Bent; Lorna Moll; Stephan Grabbe; Matthias Bros
Journal:  Int J Mol Sci       Date:  2018-07-24       Impact factor: 5.923
  3 in total

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