Literature DB >> 3502066

Identification of transforming growth factor alpha in human primary breast carcinomas.

A Macias1, R Perez, T Hägerström, L Skoog.   

Abstract

Primary human mammary carcinomas were found to contain an acid stable polypeptide which bound to the receptor for epidermal growth factor (EGF). This polypeptide which was antigenetically different from EGF and thus identified as Tumor Growth Factor (TGF) alpha, could be identified in 25% of the tumors. Among these tumors 40% contained measurable levels of the EGF receptor. Thus these tumors exhibit the molecular prerequisite for autocrine growth stimulation.

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Year:  1987        PMID： 3502066

Source DB:  PubMed          Journal:  Anticancer Res        ISSN： 0250-7005            Impact factor:   2.480


  8 in total

1.  TGF-alpha exerts biphasic effects on estrogen--and phytoestrogen-mediated gene expression in breast cancer cells.

Authors:  S T Willard; L S Frawley
Journal:  Endocrine       Date:  1999-08       Impact factor: 3.633

2.  Epidermal growth factor-like activity and epidermal growth factor-receptors in human primary breast cancer.

Authors:  Z Kahán; M Szücs; M Vecsernyés; S Eckhardt
Journal:  Breast Cancer Res Treat       Date:  1993       Impact factor: 4.872

3.  Growth inhibition of human lung adenocarcinoma cells by antibodies against epidermal growth factor receptor and by ganglioside GM3: involvement of receptor-directed protein tyrosine phosphatase(s).

Authors:  E Suarez Pestana; U Greiser; B Sánchez; L E Fernández; A Lage; R Perez; F D Böhmer
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

4.  Elevated plasma transforming growth factor-beta 1 levels in breast cancer patients decrease after surgical removal of the tumor.

Authors:  F M Kong; M S Anscher; T Murase; B D Abbott; J D Iglehart; R L Jirtle
Journal:  Ann Surg       Date:  1995-08       Impact factor: 12.969

5.  Transforming growth factor-alpha promotes mammary tumorigenesis through selective survival and growth of secretory epithelial cells.

Authors:  G H Smith; R Sharp; E C Kordon; C Jhappan; G Merlino
Journal:  Am J Pathol       Date:  1995-10       Impact factor: 4.307

6.  Epidermal growth factor, transforming growth factor-alpha, and epidermal growth factor receptor content in normal and carcinomatous gastric and colonic tissue.

Authors:  P Borlinghaus; S Wieser; R Lamerz
Journal:  Clin Investig       Date:  1993-11

Review 7.  Transgenic mouse models of breast cancer.

Authors:  L T Amundadottir; G Merlino; R B Dickson
Journal:  Breast Cancer Res Treat       Date:  1996       Impact factor: 4.872

8.  Prognostic implication of transforming growth factor alpha in adenocarcinoma of the lung--an immunohistochemical study.

Authors:  M Tateishi; T Ishida; T Mitsudomi; K Sugimachi
Journal:  Br J Cancer       Date:  1991-01       Impact factor: 7.640
  8 in total

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