| Literature DB >> 35018604 |
Laura Bedin Denardi1,2, Carla Weiblen3, Lara Baccarin Ianiski1,4, Paula Cristina Stibbe1,4, Stefania Campos Pinto1, Janio M Santurio5,6.
Abstract
We investigated the anti-Pythium insidiosum activity of the antimicrobial peptides (AMPs) MSI-78, LL-37, and magainin-2. To detect the minimum inhibitory concentration (MIC), fourteen clinical strains were incubated with the AMPs following the CLSI M38-A2 protocol. All three AMPs showed antimicrobial activity with an MIC range of 20-80 mg/L against all strains. We concluded that the evaluated AMPs have great potential as anti-Pythium insidiosum agents, and their activity deserves to be more explored in further research. Antimicrobial peptides were tested against Pythium insidiosum, a microorganism that causes a difficult-to-treat disease in animals and humans. These peptides have been shown to be able to kill P. insidiosum and may be candidates for use in the treatment of this infection.Entities:
Keywords: Antimicrobial peptides; LL-37; MSI-78; Magainin-2; Pythium insidiosum
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Year: 2022 PMID： 35018604 PMCID： PMC8882752 DOI： 10.1007/s42770-022-00678-5
Source DB: PubMed Journal: Braz J Microbiol ISSN： 1517-8382 Impact factor: 2.476