| Literature DB >> 35015818 |
Deborah C Glass1, Christina Dimitriadis1, Jessy Hansen1, Ryan F Hoy1, Fiona Hore-Lacy1, Malcolm R Sim1.
Abstract
Silicosis is being increasingly reported among young stonemasons in the artificial stone (AS) benchtop fabrication and installation industry. Respiratory health screening, which included a job and exposure history, a chest X-ray (CXR), a respiratory health questionnaire, and gas transfer testing, were offered to stonemasons in Victoria, Australia. Workers typically reported a variety of tasks, including cleaning and labouring, which made exposure assessment complex. We estimated the relative respirable crystalline silica exposure intensity of each job from the proportion of time using AS and the proportion of time doing dry work (work without water suppression). The relative average intensity of exposure for up to five jobs was calculated. Cumulative exposure was calculated as the sum of the duration multiplied by intensity for each job. Installers and factory machinists (other than computer numeric control operators) were the most likely to report dry work with AS, and so had a greater average intensity of exposure. Exposure intensity and cumulative exposure were associated with increased odds of an ILO (International Labour Organisation) CXR profusion major category of ≥1 and with dyspnoea. Exposure duration was also associated with ILO profusion category. In multivariate analyses of health outcomes, only job type was associated with the ILO profusion category. For both most recent and longest-duration job types, when compared to the lowest exposure group, factory machinists were more likely to have an ILO category ≥1. This suggests that intensity of exposure estimated from the proportion of time dry cutting and proportion of time working on AS can predict the risk of adverse respiratory outcomes for workers in this industry.Entities:
Keywords: artificial stone; exposure; silica
Mesh:
Substances:
Year: 2022 PMID: 35015818 PMCID: PMC8751787 DOI: 10.1093/annweh/wxab044
Source DB: PubMed Journal: Ann Work Expo Health ISSN: 2398-7308 Impact factor: 2.179
Decision tree for job classification.
| Decision tree | Job category |
|---|---|
| 1. | |
| a) ≥80% of job history in ‘Other’ tasks | Other minimal secondary exposure |
| b) ≥80% of job history in ‘Other’ tasks | Other with some direct or secondary exposure |
| 2. | |
| a) ≥40% installing | Installer |
| b) <40% installing | |
| (i)≥40% on CNC | Factory worker-CNC |
| (ii)<40% on CNC | Factory worker-Machinist |
Weighting factors for exposure intensity based on proportions of dry work and type of stone (no units).
| Dry work | All artificial (1) | ≥50% artificial (0.75) | <50% artificial (0.5) | All natural (0.3) |
|---|---|---|---|---|
| Never (1) | 1 | 0.75 | 0.5 | 0.3 |
| Rarely 1 to <10% (2) | 2 | 1.5 | 1 | 0.6 |
| Sometimes 10 to 25% (4) | 4 | 3 | 2 | 1.2 |
| Frequently 25 to <50% (6) | 6 | 4.5 | 3 | 1.8 |
| Very frequently 50 to <100% (8) | 8 | 6 | 4 | 2.4 |
| Always 100% (10) | 10 | 7.5 | 5 | 3 |
Multivariate Firth logistic regression for association between demographic and exposure variables and respiratory outcomes.
| All workers, | Chest X-rayaILO 0 versus ILO ≥1 | DyspnoeaaNo versus Yes | FVCb≥LLNc versus <LLN | FEV1b≥LLN versus <LLN | FEV1/FVCb≥LLN versus <LLN | DLCOb≥LLN versus <LLN | |
|---|---|---|---|---|---|---|---|
| Male | 300 (92.6) | Reference | Reference | ||||
| Female | 24 (7.4) | 0.26 (0.05, 1.43) | 2.09 (0.86, 5.09) | ||||
| Age (years) | 36 (29, 46)d |
| 1.02 (0.99, 1.04) | ||||
| Never smoker | 147 (45.4) | Reference | Reference | ||||
| Former smoker | 75 (23.1) |
| 1.67 (0.86, 3.23) | ||||
| Current smoker | 102 (31.5) |
| 1.66 (0.91, 3.03) | ||||
| Time since first exposure years | 9 (3, 14)d |
| 1.03 (1.00, 1.07) |
| 1.06 (1.00, 1.11) | 1.02 (0.98, 1.07) |
|
| Age at first exposure years | 25 (20, 34)d |
| 0.97 (0.94, 1.01) | 1.02 (0.96, 1.08) | 1.02 (0.97, 1.07) |
| 1.00 (0.94, 1.05) |
| Summed job duration years | 6.8 (2.9, 12.5)d |
| 1.03 (0.99, 1.08) | 1.04 (0.97, 1.12) | 1.05 (0.99, 1.12) | 1.02 (0.97, 1.07) | 1.06 (1.00, 1.12) |
| Weighted job intensity | 2.9 (0.8, 5.0)d |
|
| 1.07 (0.82, 1.40) | 1.05 (0.83, 1.33) | 1.04 (0.88, 1.23) | 1.21 (0.97, 1.51) |
| Weighted cumulative exp median years | 14.7 (4.5, 41.3)d |
|
| 1.01 (1.00, 1.02) | 1.01 (1.00, 1.02) | 1.00 (1.00, 1.01) | 1.01 (1.00, 1.02) |
| Most recent job | |||||||
| Other minimal 2º exp | 40 (12.3) | 0.63 (0.19, 2.02) | 0.54 (0.19, 1.56) | 0.94 (0.15, 5.85) | 1.23 (0.28, 5.36) | 0.53 (0.13, 2.12) | 0.73 (0.12, 4.38) |
| Other some direct or 2º exp | 21 (6.5) |
| 1.22 (0.43, 3.46) | 0.39 (0.02, 7.18) | 0.29 (0.02, 5.26) | 0.42 (0.07, 2.36) | 0.25 (0.01, 4.51) |
| Factory CNC | 29 (9.0) | 1.21 (0.49, 2.98) | 0.43 (0.13, 1.38) | 2.04 (0.45, 9.25) | 0.82 (0.14, 4.83) | 0.32 (0.06, 1.78) | 1.03 (0.23, 4.55) |
| Installer | 73 (22.5) |
| 1.38 (0.75, 2.54) | 0.44 (0.07, 2.63) | 0.54 (0.13, 2.23) | 0.65 (0.26, 1.67) | 0.39 (0.10, 1.58) |
| Factory machinist | 161 (49.7) | Reference | Reference | Reference | Reference | Reference | Reference |
| Longest-duration job | |||||||
| Other minimal 2º exp | 28 (8.6) | 0.65 (0.18, 2.33) | 0.77 (0.26, 2.30) | 0.44 (0.02, 8.12) | 1.23 (0.20, 7.56) | 0.56 (0.10, 3.19) | 1.46 (0.23, 9.37) |
| Other some direct or 2º exp | 25 (7.7) |
| 0.77 (0.27, 2.23) | 1.05 (0.18, 6.33) | 0.88 (0.15, 5.20) | 0.69 (0.17, 2.76) | 0.21 (0.01, 3.81) |
| Factory CNC | 28 (8.6) | 1.09 (0.43, 2.78) | 0.62 (0.21, 1.82) | 1.19 (0.19, 7.27) | 1.00 (0.17, 5.97) | 0.74 (0.18, 3.02) | 1.47 (0.32, 6.63) |
| Installer | 63 (19.4) |
| 1.30 (0.68, 2.48) | 0.52 (0.09, 3.07) | 0.73 (0.17, 3.01) | 0.88 (0.34, 2.29) | 0.28 (0.05, 1.59) |
| Factory machinist | 180 (55.6) | Reference | Reference | Reference | Reference | Reference | Reference |
| Industry status | |||||||
| Still working | 297 (91.7) | Reference | Reference | Reference | Reference | Reference | Reference |
| Recently left | 17 (5.2) | 1.90 (0.66, 5.47) |
| 4.49 (0.70, 28.93) | 2.98 (0.48, 18.59) |
| 4.63 (0.89, 24.15) |
| Not working | 10 (3.1) | 0.69 (0.14, 3.32) | 2.59 (0.74, 9.05) |
|
| 1.57 (0.26, 9.61) |
|
Bold values show statistically significant differences. 2º exp, secondary exposure.
aAdjusted for gender, age, and smoking, CXR data missing for 10 participants.
bAdjusted for smoking (age and gender are accounted for the LLN calculations) spirometry data missing for 68 participants (another missing FVC and FEV1/FVC).
cLower limit of normal.
dInterquartile range.
Figure 2.Exposure duration, intensity, and cumulative exposure by respiratory outcomesa.aAll weighted cumulative exposure figures exclude one worker with a very high value.
Figure 1.Weighted intensity of exposure mean and 95% confidence intervals for longest-duration job.
Relative exposure intensity by job.
|
| Intensity, median (IQR) |
| |
|---|---|---|---|
| Most recent job | |||
| Other minimal secondary exposure | 40 (12.3) | 0.8 (0.6, 0.8) | <0.001 |
| Other with some direct or secondary exposure | 21 (6.5) | 1.0 (0.8, 1.5) | |
| Factory CNC | 29 (9.0) | 1.0 (0.8, 3.8) | |
| Installer | 73 (22.5) | 3.2 (2.1, 5.3) | |
| Factory machinist | 161 (49.7) | 3.5 (1.5, 5.3) | |
| Longest-duration job, | |||
| Other minimal secondary exposure | 28 (8.6) | 0.8 (0.5, 0.8) | <0.001 |
| Other with direct or secondary exposure | 25 (7.7) | 0.8 (0.8, 1.3) | |
| Factory CNC | 28 (8.6) | 0.9 (0.8, 3.2) | |
| Installer | 63 (19.4) | 3.9 (2.0, 5.1) | |
| Factory machinist | 180 (55.6) | 3.4 (1.5, 5.3) |
aKruskal–Wallis test.