| Literature DB >> 35010656 |
Frank Daumann1, Florian Follert2, Werner Gleißner3,4, Endre Kamarás4, Chantal Naumann5.
Abstract
The COVID-19 pandemic is permanently changing modern social and economic coexistence. Most governments have declared infection control to be their top priority while citizens face great restrictions on their civil rights. A pandemic is an exemplary scenario in which political actors must decide about future, and thus uncertain, events. This paper tries to present a tool well established in the field of entrepreneurial and management decision making which could also be a first benchmark for political decisions. Our approach builds on the standard epidemiological SEIR model in combination with simulation techniques used in risk management. By our case study we want to demonstrate the opportunities that risk management techniques, especially risk analyses using Monte Carlo simulation, can provide to policy makers in general, and in a public health crisis in particular. Hence, our case study can be used as a framework for political decision making under incomplete information and uncertainty. Overall, we want to point out that a health policy that aims to provide comprehensive protection against infection should also be based on economic criteria. This is without prejudice to the integration of ethical considerations in the final political decision.Entities:
Keywords: COVID-19; applied economics; business economics; decision making; health economics; health policy; public choice; public health; risk management; simulation; uncertainty
Mesh:
Year: 2021 PMID: 35010656 PMCID: PMC8744640 DOI: 10.3390/ijerph19010397
Source DB: PubMed Journal: Int J Environ Res Public Health ISSN: 1660-4601 Impact factor: 3.390
Average remaining life years.
| Age Group | Average Remaining Life Years * |
|---|---|
| 0–14 | 71.0 |
| 15–59 | 43.5 |
| 60–69 | 16.5 |
| 70–79 | 6.5 |
| 80–89 | 3.0 |
| 90+ | 3.0 |
* Determined, for simplicity, from the mean age of the group and average life expectancy at 81 years for groups under 80 years, or the average remaining life expectancy for groups over 80 years. (Simplified as the average life expectancy of new-born boys at 78.6 and that of girls at 83.4 years, according to the results of the 2017/2019 mortality table (see also https://www.destatis.de/DE/Themen/Querschnitt/Demografischer-Wandel/Aspekte/demografie-lebenserwartung.html (accessed on 27 December 2021)). Since here it was taken into account that the pre-diseased die, normal life expectancy after 80 years is approximately 9 years, but with significant pre-existing conditions, it is much shorter.
Figure 1Comparison of deaths per year: calibrated Nov. model vs. actual data.
Figure 2New infections recorded (daily); forecast mean value and bandwidth of both models.
Figure 3Number of deaths incl. unreported cases at the end of the analyzed period.
Figure 4Number of deaths without measures at the end of the analyzed period.
Figure 5Saved life years incl. unreported cases at the end of the analyzed period.
Figure 6Net costs per saved life years incl. unreported cases at the end of the analyzed period.
Basic parameters of the models.
| May Model | November Model | |
|---|---|---|
| Starting Point | 1 March 2020 | |
| Population (in million) | 82 | |
| R0 | 2.03 | 2.07 |
| Number of infected persons at starting point | 380 | 500 |
| Duration of infection time in days (Tinf) | 6 | |
| Incubation time * in days (Tinc) | 2 | 1 |
| Recovery after x days | 8 | |
| Unreported case factor at the beginning/in the long run ** | 17.5/10 | 7/4 |
| Starting point of uncertainty | 18 January 2020 | 11 October 2020 |
* Already infected but not yet infectious. ** Determined based on estimates and our own calculation in connection with the replication of the course between 1 March 2020 and 3 May 2020. For estimates of the number of unreported cases, see also Heinsberg-Studie Streeck H, Schulte B, Kümmerer B, et al. Infection fatality rate of SARS-CoV-2 infection in a German community with a super-spreading event, https://doi.org/.1101/.05.04.20090076 and https://www.aerzteblatt.de/nachrichten/111854/Hohe-Dunkelziffer-Zahl-der-Infizierten-in-Deutschland-moeglicherweise-schon-bei-460-000 (accessed on 27 December 2021), based on estimates and our own calculation in connection with the replication of the course between 1 March 2020 and 11 October 2020. For estimates of the number of unreported cases, see also the KoCo19 Study Team headed by Prof. Dr. Michael Hölscher, Prof. Dr. Katja Radon, Prof. Dr. Christiane Fuchs, Prof. Dr. Jan Hasenauer and PD Dr. Andreas Wieser: Prospective COVID-19 Cohort Munich (KoCo19): Summary of the epidemiological results of the initial study http://www.klinikum.uni-muenchen.de/Abteilung-fuer-Infektions-und-Tropenmedizin/download/de/KoCo191/Zusammenfassung_KoCo19_Epi_dt_041120.pdf (accessed on 27 December 2021).
Adapted parameters of the models.
| Parameters | (Static) Value for Calibration | |
|---|---|---|
| May Model | Nov. Model | |
| Date of first recommendation | 11 March 2020 (the 10th day) | |
| Max. reduction factor * of the first recommendation | 65% | 60% |
| δR of the first recommendation | −0.02 | −0.09 |
| Date of the “shutdown” | 22 January 2020 (the 22nd day) | |
| Max. reduction factor of the “shutdown” | 70% | 71% |
| δRcontain of the “shutdown” (per day) | −0.04 | −0.06 |
| Relaxation from | 20 April 2020 (the 49th day) | |
| δRloose “relaxation” (per day) | ||
| between April and July | +0.0027 | +0.0023 |
| between August and March | +0.0027 | +0.0048 |
| “retightening” (mini-lockdown) | ------------- | 6 October 2020 (the 218th day) |
* The percent by which R is maximally reduced by the measure.
Relaxation and retightening of measures.
| Initiation of a Phase before the Introduction of a Vaccine | Condition | Period (Consecutive Days) | ||
|---|---|---|---|---|
| May Model | Nov. Model | May Model | Nov. Model | |
| Relaxation phase | R < 0.85 | R < 0.80 | 10 | 14 |
| Retightening of measures after R or | R > 1.3 | 12 | ||
| Retightening of measures after net new infections (greater than) | 1300 | 10,000 | 12 | |
Uncertain effect of the measures used for the forecast on R or on the costs.
| Effect of the Measures on R (Per Day) * | Min | Probable | Max | Minimum Value R | ||||
|---|---|---|---|---|---|---|---|---|
| May | Nov. | May | Nov. | May | Nov. | May | Nov. | |
| Relaxation phase | 0.036 | 0.0019 | 0.04 | 0.002 | 0.044 | 0.0023 | 0.75 | |
| Retightening of measures | −0.009 | −0.01 | −0.011 | 0.61 | 0.75 | |||
| After introduction of a vaccine | −0.009 | −0.01 | −0.011 | 0.5 | 0.7 | |||
* Our own calculations.
Relative uncertainty ranges of costs in EUR bn.
| Phase | Min | Probable | Max | |||
|---|---|---|---|---|---|---|
| May | Nov. | May | Nov. | May | Nov. | |
| 1st-month complete shutdown | 255 | 186 | 375 | 207 | 495 | 228 |
| 1st-month complete shutdown per day | 8.5 | 6.21 | 12.5 | 6.9 | 16.5 | 7.59 |
| further complete shutdown per day | 3.57 | 1.97 | 5.86 | 3,23 | 8.14 | 4.49 |
Estimated proportional costs.
| Cost Factor (Related to Shutdown Costs) | Min | Probable | Max | |||
|---|---|---|---|---|---|---|
| May | Nov. | May | Nov. | May | Nov. | |
| Relaxation phase | 0.225 | 0.29 | 0.25 | 0.32 | 0.275 | 0.35 |
| Retightening | 0.45 | 0.58 | 0.5 | 0.64 | 0.55 | 0.71 |
Estimation of unreported cases.
| Value | |
|---|---|
| Starting value | 3% |
| Reduction per period (share of previous period) | 25% |
| Minimum value | 0% |
Introduction of a vaccine.
| Earliest | Probable | Latest | ||||
|---|---|---|---|---|---|---|
| May | Nov. | May | Nov. | May | Nov. | |
| Date of introduction of a vaccine | 1 December 2020 | 9 January 2021 | 2 July 2021 | 8 March 2021 | 3 May 2023 | 8 November 2022 |
Known cases of illness by age group.
| Age Group | Infected | Share of Infected | ||
|---|---|---|---|---|
| May | Nov. | May * | Nov. ** | |
| 0–4 | 1224 | 14,591 | 0.82% | 1.90% |
| 5–14 | 3042 | 44,614 | 2.03% | 5.82% |
| 15–34 | 36,548 | 254,811 | 24.40% | 33.27% |
| 35–59 | 63,815 | 296,169 | 42.61% | 38,66% |
| 60–79 | 28,773 | 106,428 | 19.21% | 13.89% |
| 80+ | 16,357 | 49,378 | 10.92% | 6.45% |
| TOTAL | 149,759 | 765,991 | 100% | 100% |
* Source: https://experience.arcgis.com/experience/478220a4c454480e823b17327b2bf1d4/page/page_0/ (accessed on 23 April 2020). ** Source: https://experience.arcgis.com/experience/478220a4c454480e823b17327b2bf1d4/page/page_0/ (accessed on 12 November 2020).
Share of death by age group.
| Age Group | Death | Share of Death * | ||
|---|---|---|---|---|
| May | Nov. | May | Nov. | |
| 0–59 | 226 | 566 | 4.44% | 4.92% |
| 60–69 | 457 | 1072 | 8.98% | 9.32% |
| 70–79 | 1197 | 2535 | 23.52% | 22.05% |
| 80–89 | 2308 | 5090 | 45.34% | 44.27% |
| 90+ | 902 | 2235 | 17.72% | 19.44% |
| TOTAL | 5090 | 11,498 | 100% | 100% |
* Source: https://experience.arcgis.com/experience/478220a4c454480e823b17327b2bf1d4/page/page_0/ (accessed on 23 April 2020 and 12 November 2020).
Average remaining years by age group.
| Age Group | Proportion of Deceased Patients * | Average Remaining Years ** (Both Models) | |
|---|---|---|---|
| May | Nov. | ||
| 0–14 | 0.03% | 0.04% | 71.0 |
| 14–59 | 4.36% | 4.88% | 43.5 |
| 59–69 | 8.92% | 9.32% | 16.5 |
| 70–79 | 22.66% | 22.05% | 6.5 |
| 80–89 | 45.43% | 44.27% | 3 |
| 90+ | 18.60% | 19.44% | 3 |
* Source: https://experience.arcgis.com/experience/478220a4c454480e823b17327b2bf1d4/page/page_0/ (accessed on 23 April 2020 and 12 November 2020). ** Simplified; calculated from the mean age of the group and average life expectancy at 81 years (for groups under 80 years) or the average remaining life expectancy for groups over 80 years.
Mortality in relation to the number of infected persons.
| Mortality | Min | Probable | Max | |||
|---|---|---|---|---|---|---|
| May | Nov. | May | Nov. | May | Nov. | |
| Known cases | 4.9% | 1.4% | 5.4% | 1.7% | 6.0% | 2.0% |
| Unreported cases | 0.05% | |||||