Literature DB >> 3500852

Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene.

K Yasukawa1, T Hirano, Y Watanabe, K Muratani, T Matsuda, S Nakai, T Kishimoto.   

Abstract

The chromosomal DNA segment of human B cell stimulatory factor-2 (BSF-2/IL-6) was isolated and characterized by nucleotide sequence analysis. The human BSF-2/IL-6 gene consists of five exons and four introns and its organization shows a distinctive similarity to granulocyte colony-stimulating factor gene. The two genes have the same number of exons and introns and the size of each exon is strikingly similar. The BSF-2/IL-6 mRNA was found to be constitutively expressed in a human T cell leukemia virus-1 transformed T cell line, TCL-Na1, a bladder cell carcinoma line, T24, and an amnion derived cell line, FL. The BSF-2/IL-6 mRNA was also found to be inducible with interleukin-1 beta in an astrocytoma line, U373 and a glioblastoma line, SK-MG-4. S1 mapping and primer extension analyses showed the presence of multiple initiation sites and the preferential utilization of a different initiation site for each individual tissue tested.

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Year:  1987        PMID： 3500852      PMCID： PMC553729          DOI： 10.1002/j.1460-2075.1987.tb02598.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  40 in total

1.  Base composition-independent hybridization in tetramethylammonium chloride: a method for oligonucleotide screening of highly complex gene libraries.

Authors:  W I Wood; J Gitschier; L A Lasky; R M Lawn
Journal:  Proc Natl Acad Sci U S A       Date:  1985-03       Impact factor: 11.205

Review 2.  B cell growth and differentiation factors and mechanism of B cell activation.

Authors:  T Kishimoto; K Yoshizaki; M Kimoto; M Okada; T Kuritani; H Kikutani; K Shimizu; T Nakagawa; N Nakagawa; Y Miki
Journal:  Immunol Rev       Date:  1984-04       Impact factor: 12.988

3.  Identification of regulatory sequences in the prelude sequences of an H2A histone gene by the study of specific deletion mutants in vivo.

Authors:  R Grosschedl; M L Birnstiel
Journal:  Proc Natl Acad Sci U S A       Date:  1980-03       Impact factor: 11.205

4.  Neuroleukin: a lymphokine product of lectin-stimulated T cells.

Authors:  M E Gurney; B R Apatoff; G T Spear; M J Baumel; J P Antel; M B Bania; A T Reder
Journal:  Science       Date:  1986-10-31       Impact factor: 47.728

5.  Immortalization of BGDF (BCGF II)- and BCDF-producing T cells by human T cell leukemia virus (HTLV) and characterization of human BGDF (BCGF II).

Authors:  K Shimizu; T Hirano; K Ishibashi; N Nakano; T Taga; K Sugamura; Y Yamamura; T Kishimoto
Journal:  J Immunol       Date:  1985-03       Impact factor: 5.422

6.  Primary structure of human transferrin receptor deduced from the mRNA sequence.

Authors:  C Schneider; M J Owen; D Banville; J G Williams
Journal:  Nature       Date:  1984 Oct 18-24       Impact factor: 49.962

7.  Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1.

Authors:  J Van Damme; M De Ley; G Opdenakker; A Billiau; P De Somer; J Van Beeumen
Journal:  Nature       Date:  1985 Mar 21-27       Impact factor: 49.962

8.  Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin.

Authors:  T Hirano; K Yasukawa; H Harada; T Taga; Y Watanabe; T Matsuda; S Kashiwamura; K Nakajima; K Koyama; A Iwamatsu
Journal:  Nature       Date:  1986 Nov 6-12       Impact factor: 49.962

9.  Structure of the human interleukin-2 receptor gene.

Authors:  W J Leonard; J M Depper; M Kanehisa; M Krönke; N J Peffer; P B Svetlik; M Sullivan; W C Greene
Journal:  Science       Date:  1985-11-08       Impact factor: 47.728

10.  Molecular structure of human lymphocyte receptor for immunoglobulin E.

Authors:  H Kikutani; S Inui; R Sato; E L Barsumian; H Owaki; K Yamasaki; T Kaisho; N Uchibayashi; R R Hardy; T Hirano
Journal:  Cell       Date:  1986-12-05       Impact factor: 41.582
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  108 in total

1.  Autoregulatory effect of interleukin-10 on proinflammatory cytokine production by Porphyromonas gingivalis lipopolysaccharide-tolerant human monocytes.

Authors:  H Shimauchi; T Ogawa; K Okuda; Y Kusumoto; H Okada
Journal:  Infect Immun       Date:  1999-05       Impact factor: 3.441

Review 2.  Interleukin-6 and insulin sensitivity: friend or foe?

Authors:  A L Carey; M A Febbraio
Journal:  Diabetologia       Date:  2004-07-07       Impact factor: 10.122

3.  Structure of the chicken myelomonocytic growth factor gene and specific activation of its promoter in avian myelomonocytic cells by protein kinases.

Authors:  E Sterneck; C Blattner; T Graf; A Leutz
Journal:  Mol Cell Biol       Date:  1992-04       Impact factor: 4.272

4.  Cloning and sequence analysis of the cDNA for murine interleukin-6.

Authors:  H E Grenett; N L Fuentes; G M Fuller
Journal:  Nucleic Acids Res       Date:  1990-11-11       Impact factor: 16.971

Review 5.  Polypeptides controlling hematopoietic cell development and activation. I. In vitro results.

Authors:  F Herrmann; R Mertelsmann
Journal:  Blut       Date:  1989-03

6.  Intestinal inflammation-induced growth retardation acts through IL-6 in rats and depends on the -174 IL-6 G/C polymorphism in children.

Authors:  Andrew Sawczenko; Omeia Azooz; Joanna Paraszczuk; Maja Idestrom; Nick M Croft; Martin O Savage; Anne B Ballinger; Ian R Sanderson
Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-06       Impact factor: 11.205

7.  Beta interferon subtype 1 induction by tumor necrosis factor.

Authors:  H Jacobsen; J Mestan; S Mittnacht; C W Dieffenbach
Journal:  Mol Cell Biol       Date:  1989-07       Impact factor: 4.272

8.  Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells.

Authors:  C P Chiu; C Moulds; R L Coffman; D Rennick; F Lee
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205

9.  Interleukin 2-dependent and interleukin 2-independent pathways of regulation of thymocyte function by interleukin 6.

Authors:  J M Le; G Fredrickson; L F Reis; T Diamantstein; T Hirano; T Kishimoto; J Vilcek
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

10.  Interleukin-6 and interleukin-6 receptor gene expression in pituitary tumors.

Authors:  A R Rezai; A Rezai; O Martínez-Maza; M Vander-Meyden; M H Weiss
Journal:  J Neurooncol       Date:  1994       Impact factor: 4.130
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