| Literature DB >> 31559401 |
Shatadru Chakravarty1, Saurav J Sarma2, Lalit N Goswami3, Quan-Yu Cai4, Erik M Shapiro5, M Frederick Hawthorne3, Lixin Ma4.
Abstract
A multimeric MRI contrast agent based on the closo-borane motif is reported. Twelve copies of a modified AAZTA chelate with an alkyne end group are appended on an azide-functionalized closo-borane motif using Cu(i) catalyzed click chemistry. The presence of two water molecules on the Gd-bound AAZTA chelate results in high relaxivity for the closomer in vitro/in vivo.Entities:
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Year: 2019 PMID： 31559401 DOI： 10.1039/c9cc05383b
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222