Magnetic Resonance Imaging of Rat Brain in Assessment of the Neuroprotective Properties of Histochrome in Experimental Arterial Hypertension.

The neuroprotective effects of the course therapy with Histochrome in Wistar rats with modeled arterial hypertension were studied by using magnetic resonance imaging (MRI) in diffusion-weighted mode. The behavioral status of the animals was assessed using the open-field test. MRI analysis revealed more pronounced increase in the signaling characteristics of the brain tissue in hypertensive rats in comparison with the control (intact) animals. It was caused by excessive accumulation of fluid in the intra- and extracellular spaces of the brain tissue, which is associated with hypervolemia induced by the multifactorial cardiovasorenal model of hypertension. After a course of Histochrome injections to hypertensive rats, the cerebral microcirculation disorders were leveled, while the behavioral status was characterized by shortened latency of the visit to the center of the open field by 20% and improvement of cognitive activity (by 1.6 times) and the exploratory component (by 30%).