Background: The factors that trigger and exacerbate chronic spontaneous urticaria (CSU) are well known, but it is not unclear whether messenger RNA (mRNA) vaccination against severe acute respiratory syndrome coronavirus 2 can trigger new cases of CSU or a relapse of CSU after long-term remission. Objective: To study the clinical cases of patients with new-onset CSU and CSU in remission who relapsed within 3 months after BNT162b2 mRNA vaccination. Methods: All patients with a CSU diagnosis within 12 weeks of BNT162b2 mRNA vaccination were retrospectively identified and included in the new-onset CSU and the relapsed CSU groups. The first control group (CSU control group) retrospectively consisted of patients diagnosed with CSU in complete clinical remission for ≥ 6 months, with no CSU relapse after vaccination. The second control group (healthy control group) consisted of subjects who were fully vaccinated and without CSU, matched 1:2 for age and sex with patients with CSU. Results: Twenty-seven patients were included in the relapsed CSU group, 32 patients in the new-onset CSU group, 179 patients in the CSU control group, and 476 subjects in the healthy control group. The relapsed CSU and new-onset CSU groups had more allergic comorbidities overall (19 [70.4%] and 13 [40.6%], respectively) than the CSU control group and the healthy control group (50 [27.9%] and 110 [23.1%], respectively; p < 0.001). Multiple logistic regression analysis showed that a positive autologous serum skin test result, overall allergic comorbidities, and basopenia were positively associated with the probability of CSU relapse within 3 months after BNT162b2 mRNA vaccination (odds ratio [OR] 5.54 [95% confidence interval {CI}, 2.36-13.02], p < 0.001); OR 6.13 [95% CI, 2.52-14.89], p = 0.001; and OR 2.81 [95% CI, 1.17-6.72, p = 0.020, respectively). Conclusion: It is possible that BNT162b2 mRNA vaccination serves as a provoking and/or relapsing factor of CSU in individuals with allergic diseases and/or predisposed autoimmunity.
Background: The factors that trigger and exacerbate chronic spontaneous urticaria (CSU) are well known, but it is not unclear whether messenger RNA (mRNA) vaccination against severe acute respiratory syndrome coronavirus 2 can trigger new cases of CSU or a relapse of CSU after long-term remission. Objective: To study the clinical cases of patients with new-onset CSU and CSU in remission who relapsed within 3 months after BNT162b2 mRNA vaccination. Methods: All patients with a CSU diagnosis within 12 weeks of BNT162b2 mRNA vaccination were retrospectively identified and included in the new-onset CSU and the relapsed CSU groups. The first control group (CSU control group) retrospectively consisted of patients diagnosed with CSU in complete clinical remission for ≥ 6 months, with no CSU relapse after vaccination. The second control group (healthy control group) consisted of subjects who were fully vaccinated and without CSU, matched 1:2 for age and sex with patients with CSU. Results: Twenty-seven patients were included in the relapsed CSU group, 32 patients in the new-onset CSU group, 179 patients in the CSU control group, and 476 subjects in the healthy control group. The relapsed CSU and new-onset CSU groups had more allergic comorbidities overall (19 [70.4%] and 13 [40.6%], respectively) than the CSU control group and the healthy control group (50 [27.9%] and 110 [23.1%], respectively; p < 0.001). Multiple logistic regression analysis showed that a positive autologous serum skin test result, overall allergic comorbidities, and basopenia were positively associated with the probability of CSU relapse within 3 months after BNT162b2 mRNA vaccination (odds ratio [OR] 5.54 [95% confidence interval {CI}, 2.36-13.02], p < 0.001); OR 6.13 [95% CI, 2.52-14.89], p = 0.001; and OR 2.81 [95% CI, 1.17-6.72, p = 0.020, respectively). Conclusion: It is possible that BNT162b2 mRNA vaccination serves as a provoking and/or relapsing factor of CSU in individuals with allergic diseases and/or predisposed autoimmunity.
Authors: Emek Kocatürk; Andaç Salman; Ivan Cherrez-Ojeda; Paulo Ricardo Criado; Jonny Peter; Elif Comert-Ozer; Mohamed Abuzakouk; Rosana Câmara Agondi; Mona Al-Ahmad; Sabine Altrichter; Rand Arnaout; Luisa Karla Arruda; Riccardo Asero; Andrea Bauer; Moshe Ben-Shoshan; Jonathan A Bernstein; Mojca Bizjak; Isabelle Boccon-Gibod; Hanna Bonnekoh; Laurence Bouillet; Zenon Brzoza; Paula Busse; Regis A Campos; Emily Carne; Niall Conlon; Roberta F Criado; Eduardo M de Souza Lima; Semra Demir; Joachim Dissemond; Sibel Doğan Günaydın; Irina Dorofeeva; Luis Felipe Ensina; Ragıp Ertaş; Silvia Mariel Ferrucci; Ignasi Figueras-Nart; Daria Fomina; Sylvie M Franken; Atsushi Fukunaga; Ana M Giménez-Arnau; Kiran Godse; Margarida Gonçalo; Maia Gotua; Clive Grattan; Carole Guillet; Naoko Inomata; Thilo Jakob; Gul Karakaya; Alicja Kasperska-Zając; Constance H Katelaris; Mitja Košnik; Dorota Krasowska; Kanokvalai Kulthanan; M Sendhil Kumaran; Claudia Lang; José Ignacio Larco-Sousa; Elisavet Lazaridou; Tabi Anika Leslie; Undine Lippert; Oscar Calderón Llosa; Michael Makris; Alexander Marsland; Iris V Medina; Raisa Meshkova; Esther Bastos Palitot; Claudio A S Parisi; Julia Pickert; German D Ramon; Mónica Rodríguez-Gonzalez; Nelson Rosario; Michael Rudenko; Krzysztof Rutkowski; Jorge Sánchez; Sibylle Schliemann; Bulent Enis Sekerel; Faradiba S Serpa; Esther Serra-Baldrich; Zhiqiang Song; Angèle Soria; Maria Staevska; Petra Staubach; Anna Tagka; Shunsuke Takahagi; Simon Francis Thomsen; Regina Treudler; Zahava Vadasz; Solange Oliveira Rodrigues Valle; Martijn B A Van Doorn; Christian Vestergaard; Nicola Wagner; Dahu Wang; Liangchun Wang; Bettina Wedi; Paraskevi Xepapadaki; Esra Yücel; Anna Zalewska-Janowska; Zuotao Zhao; Torsten Zuberbier; Marcus Maurer Journal: Allergy Date: 2020-12-07 Impact factor: 13.146
Authors: Vanitha Sampath; Grace Rabinowitz; Mihir Shah; Surabhi Jain; Zuzana Diamant; Milos Jesenak; Ronald Rabin; Stefan Vieths; Ioana Agache; Mübeccel Akdis; Domingo Barber; Heimo Breiteneder; Sharon Chinthrajah; Tomas Chivato; William Collins; Thomas Eiwegger; Katharine Fast; Wytske Fokkens; Robyn E O'Hehir; Markus Ollert; Liam O'Mahony; Oscar Palomares; Oliver Pfaar; Carmen Riggioni; Mohamed H Shamji; Milena Sokolowska; Maria Jose Torres; Claudia Traidl-Hoffmann; Menno van Zelm; De Yun Wang; Luo Zhang; Cezmi A Akdis; Kari C Nadeau Journal: Allergy Date: 2021-06-04 Impact factor: 13.146
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Authors: Kizzmekia S Corbett; Darin K Edwards; Sarah R Leist; Olubukola M Abiona; Seyhan Boyoglu-Barnum; Rebecca A Gillespie; Sunny Himansu; Alexandra Schäfer; Cynthia T Ziwawo; Anthony T DiPiazza; Kenneth H Dinnon; Sayda M Elbashir; Christine A Shaw; Angela Woods; Ethan J Fritch; David R Martinez; Kevin W Bock; Mahnaz Minai; Bianca M Nagata; Geoffrey B Hutchinson; Kai Wu; Carole Henry; Kapil Bahl; Dario Garcia-Dominguez; LingZhi Ma; Isabella Renzi; Wing-Pui Kong; Stephen D Schmidt; Lingshu Wang; Yi Zhang; Emily Phung; Lauren A Chang; Rebecca J Loomis; Nedim Emil Altaras; Elisabeth Narayanan; Mihir Metkar; Vlad Presnyak; Cuiping Liu; Mark K Louder; Wei Shi; Kwanyee Leung; Eun Sung Yang; Ande West; Kendra L Gully; Laura J Stevens; Nianshuang Wang; Daniel Wrapp; Nicole A Doria-Rose; Guillaume Stewart-Jones; Hamilton Bennett; Gabriela S Alvarado; Martha C Nason; Tracy J Ruckwardt; Jason S McLellan; Mark R Denison; James D Chappell; Ian N Moore; Kaitlyn M Morabito; John R Mascola; Ralph S Baric; Andrea Carfi; Barney S Graham Journal: Nature Date: 2020-08-05 Impact factor: 49.962
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