| Literature DB >> 32756549 |
Kizzmekia S Corbett1, Darin K Edwards2, Sarah R Leist3, Olubukola M Abiona1, Seyhan Boyoglu-Barnum1, Rebecca A Gillespie1, Sunny Himansu2, Alexandra Schäfer3, Cynthia T Ziwawo1, Anthony T DiPiazza1, Kenneth H Dinnon3, Sayda M Elbashir2, Christine A Shaw2, Angela Woods2, Ethan J Fritch4, David R Martinez3, Kevin W Bock5, Mahnaz Minai5, Bianca M Nagata5, Geoffrey B Hutchinson1, Kai Wu2, Carole Henry2, Kapil Bahl2, Dario Garcia-Dominguez2, LingZhi Ma2, Isabella Renzi2, Wing-Pui Kong1, Stephen D Schmidt1, Lingshu Wang1, Yi Zhang1, Emily Phung1,6, Lauren A Chang1, Rebecca J Loomis1, Nedim Emil Altaras2, Elisabeth Narayanan2, Mihir Metkar2, Vlad Presnyak2, Cuiping Liu1, Mark K Louder1, Wei Shi1, Kwanyee Leung1, Eun Sung Yang1, Ande West3, Kendra L Gully3, Laura J Stevens7, Nianshuang Wang8, Daniel Wrapp8, Nicole A Doria-Rose1, Guillaume Stewart-Jones2, Hamilton Bennett2, Gabriela S Alvarado1, Martha C Nason9, Tracy J Ruckwardt1, Jason S McLellan8, Mark R Denison7, James D Chappell7, Ian N Moore5, Kaitlyn M Morabito1, John R Mascola1, Ralph S Baric3,4, Andrea Carfi10, Barney S Graham11.
Abstract
A vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is needed to control the coronavirus disease 2019 (COVID-19) global pandemic. Structural studies have led to the development of mutations that stabilize Betacoronavirus spike proteins in the prefusion state, improving their expression and increasing immunogenicity1. This principle has been applied to design mRNA-1273, an mRNA vaccine that encodes a SARS-CoV-2 spike protein that is stabilized in the prefusion conformation. Here we show that mRNA-1273 induces potent neutralizing antibody responses to both wild-type (D614) and D614G mutant2 SARS-CoV-2 as well as CD8+ T cell responses, and protects against SARS-CoV-2 infection in the lungs and noses of mice without evidence of immunopathology. mRNA-1273 is currently in a phase III trial to evaluate its efficacy.Entities:
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Year: 2020 PMID： 32756549 PMCID： PMC7581537 DOI： 10.1038/s41586-020-2622-0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962