Literature DB >> 34978891

Is the Success of Cefazolin plus Ertapenem in Methicillin-Susceptible Staphylococcus aureus Bacteremia Based on Release of Interleukin-1 Beta?

Dan Smelter1, Mary Hayney1, George Sakoulas2, Warren Rose1.   

Abstract

Cefazolin and ertapenem have been shown to be an effective salvage regimen for refractory methicillin-susceptible Staphylococcus aureus bacteremia. Our findings suggest cefazolin plus ertapenem in vitro stimulates interleukin-1β release from peripheral blood monocytes both with and without S. aureus presence. This IL-1β augmentation was primarily driven by ertapenem. These findings support further exploration of cefazolin plus ertapenem in MSSA bacteremia and may partially explain its marked potency in vivo despite modest synergy in vitro.

Entities:  

Keywords:  antimicrobial combinations; beta-lactams; immunology; in vitro; innate immunity

Mesh：

Substances：

Year:  2022        PMID： 34978891      PMCID： PMC8846438          DOI： 10.1128/aac.02166-21

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.938


  23 in total

Review 1.  Avoiding the perfect storm: the biologic and clinical case for reevaluating the 7-day expectation for methicillin-resistant Staphylococcus aureus bacteremia before switching therapy.

Authors:  Ravina Kullar; James A McKinnell; George Sakoulas
Journal:  Clin Infect Dis       Date:  2014-07-21       Impact factor: 9.079

2.  IL-1β is an innate immune sensor of microbial proteolysis.

Authors:  Christopher N LaRock; Jordan Todd; Doris L LaRock; Joshua Olson; Anthony J O'Donoghue; Avril A B Robertson; Matthew A Cooper; Hal M Hoffman; Victor Nizet
Journal:  Sci Immunol       Date:  2016-08-19

Review 3.  Is a Reported Penicillin Allergy Sufficient Grounds to Forgo the Multidimensional Antimicrobial Benefits of β-Lactam Antibiotics?

Authors:  George Sakoulas; Matthew Geriak; Victor Nizet
Journal:  Clin Infect Dis       Date:  2019-01-01       Impact factor: 9.079

4.  Inappropriate use of antibiotics exacerbates inflammation through OMV-induced pyroptosis in MDR Klebsiella pneumoniae infection.

Authors:  Chao Ye; Weiran Li; Ying Yang; Qingwen Liu; Sijing Li; Peng Zheng; Xiao Zheng; Ye Zhang; Jinrong He; Yongjun Chen; Liangqun Hua; Zhongqian Yang; Duo Li; Zhaoling Ren; Ying Yang; Jialong Qi; Weiwei Huang; Yanbing Ma
Journal:  Cell Rep       Date:  2021-09-21       Impact factor: 9.423

5.  Elevated serum interleukin-10 at time of hospital admission is predictive of mortality in patients with Staphylococcus aureus bacteremia.

Authors:  Warren E Rose; Jens C Eickhoff; Sanjay K Shukla; Madhulatha Pantrangi; Suzan Rooijakkers; Sara E Cosgrove; Victor Nizet; George Sakoulas
Journal:  J Infect Dis       Date:  2012-09-10       Impact factor: 5.226

6.  Comparative pharmacokinetics, pharmacodynamics, and tolerability of ertapenem 1 gram/day administered as a rapid 5-minute infusion versus the standard 30-minute infusion in healthy adult volunteers.

Authors:  Dora E Wiskirchen; Seth T Housman; Richard Quintiliani; David P Nicolau; Joseph L Kuti
Journal:  Pharmacotherapy       Date:  2013-02-11       Impact factor: 4.705

7.  Epidemiology of bloodstream infections caused by methicillin-resistant Staphylococcus aureus at a tertiary care hospital in New York.

Authors:  Mohamad Yasmin; Halim El Hage; Rita Obeid; Hanine El Haddad; Mazen Zaarour; Ambreen Khalil
Journal:  Am J Infect Control       Date:  2015-09-26       Impact factor: 2.918

8.  Cefazolin and Ertapenem Salvage Therapy Rapidly Clears Persistent Methicillin-Susceptible Staphylococcus aureus Bacteremia.

Authors:  Erlinda R Ulloa; Kavindra V Singh; Matthew Geriak; Fadi Haddad; Barbara E Murray; Victor Nizet; George Sakoulas
Journal:  Clin Infect Dis       Date:  2020-09-12       Impact factor: 9.079

Review 9.  Role of the inflammasome, IL-1β, and IL-18 in bacterial infections.

Authors:  Manoranjan Sahoo; Ivonne Ceballos-Olvera; Laura del Barrio; Fabio Re
Journal:  ScientificWorldJournal       Date:  2011-11-01

Review 10.  Phenotypic and Genotypic Characteristics of Methicillin-Resistant Staphylococcus aureus (MRSA) Related to Persistent Endovascular Infection.

Authors:  Liang Li; Michael R Yeaman; Arnold S Bayer; Yan Q Xiong
Journal:  Antibiotics (Basel)       Date:  2019-05-29
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  1 in total

1.  Potent Activity of Ertapenem Plus Cefazolin Within Staphylococcal Biofilms: A Contributing Factor in the Treatment of Methicillin-Susceptible Staphylococcus aureus Endocarditis.

Authors:  Jessica Gilbertie; Erlinda R Ulloa; Jennifer C Daiker; Khanh Nguyen; Dan Smelter; Warren Rose; Matthew Geriak; Lauren V Schnabel; Victor Nizet; George Sakoulas
Journal:  Open Forum Infect Dis       Date:  2022-03-23       Impact factor: 4.423
  1 in total

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