Literature DB >> 31773134

Cefazolin and Ertapenem Salvage Therapy Rapidly Clears Persistent Methicillin-Susceptible Staphylococcus aureus Bacteremia.

Erlinda R Ulloa1,2, Kavindra V Singh3,4, Matthew Geriak5, Fadi Haddad6, Barbara E Murray3,4, Victor Nizet1,7, George Sakoulas1,5.   

Abstract

Cefazolin and ertapenem combination therapy was used successfully to salvage 11 cases (6 endocarditis) of persistent methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia, including immediate clearance (≤24 hours) in 8 cases. While in vitro synergy was modest, cefazolin plus ertapenem exhibited synergistic action in a rat model of MSSA endocarditis. The combination of cefazolin and ertapenem provides potent in vivo activity against MSSA beyond what is predicted in vitro and warrants further clinical study in the treatment of refractory MSSA bacteremia and endocarditis.
© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  Staphylococcus aureus; bacteremia; cefazolin; endocarditis; ertapenem

Mesh：

Substances：

Year:  2020        PMID： 31773134      PMCID： PMC7486850          DOI： 10.1093/cid/ciz995

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  26 in total

1.  Cefazolin therapy for Staphylococcus aureus bacteremia.

Authors:  Manuel L Fernández-Guerrero; Miguel de Górgolas
Journal:  Clin Infect Dis       Date:  2005-07-01       Impact factor: 9.079

2.  Cefazolin versus anti-staphylococcal penicillins for the treatment of patients with Staphylococcus aureus bacteraemia.

Authors:  S Weis; M Kesselmeier; J S Davis; A M Morris; S Lee; A Scherag; S Hagel; M W Pletz
Journal:  Clin Microbiol Infect       Date:  2019-03-27       Impact factor: 8.067

Review 3.  When does 2 plus 2 equal 5? A review of antimicrobial synergy testing.

Authors:  Christopher D Doern
Journal:  J Clin Microbiol       Date:  2014-06-11       Impact factor: 5.948

4.  Clinical experiences with cefazolin and other cephalosporins in bacterial endocarditis.

Authors:  E L Quinn; D Pohlod; T Madhavan; K Burch; E Fisher; F Cox
Journal:  J Infect Dis       Date:  1973-10       Impact factor: 5.226

5.  Efficacy of Ceftaroline against Methicillin-Susceptible Staphylococcus aureus Exhibiting the Cefazolin High-Inoculum Effect in a Rat Model of Endocarditis.

Authors:  Kavindra V Singh; Truc T Tran; Esteban C Nannini; Vincent H Tam; Cesar A Arias; Barbara E Murray
Journal:  Antimicrob Agents Chemother       Date:  2017-06-27       Impact factor: 5.191

6.  Changes in the treatment of Enterococcus faecalis infective endocarditis in Spain in the last 15 years: from ampicillin plus gentamicin to ampicillin plus ceftriaxone.

Authors:  J M Pericas; C Cervera; A del Rio; A Moreno; C Garcia de la Maria; M Almela; C Falces; S Ninot; X Castañeda; Y Armero; D Soy; J M Gatell; F Marco; C A Mestres; J M Miro
Journal:  Clin Microbiol Infect       Date:  2014-08-11       Impact factor: 8.067

7.  Cefazolin high-inoculum effect in methicillin-susceptible Staphylococcus aureus from South American hospitals.

Authors:  Sandra Rincón; Jinnethe Reyes; Lina Paola Carvajal; Natalia Rojas; Fabián Cortés; Diana Panesso; Manuel Guzmán; Jeannete Zurita; Javier A Adachi; Barbara E Murray; Esteban C Nannini; Cesar A Arias
Journal:  J Antimicrob Chemother       Date:  2013-06-21       Impact factor: 5.790

8.  Unsuccessful treatment of staphylococcal endocarditis with cefazolin.

Authors:  R E Bryant; R H Alford
Journal:  JAMA       Date:  1977-02-07       Impact factor: 56.272

9.  Comparison of cefazolin versus oxacillin for treatment of complicated bacteremia caused by methicillin-susceptible Staphylococcus aureus.

Authors:  Julius Li; Kelly L Echevarria; Darrel W Hughes; Jose A Cadena; Jason E Bowling; James S Lewis
Journal:  Antimicrob Agents Chemother       Date:  2014-06-16       Impact factor: 5.191

10.  Standard susceptibility testing overlooks potent azithromycin activity and cationic peptide synergy against MDR Stenotrophomonas maltophilia.

Authors:  Monika Kumaraswamy; Leo Lin; Joshua Olson; Ching-Fang Sun; Poochit Nonejuie; Ross Corriden; Simon Döhrmann; Syed Raza Ali; Deirdre Amaro; Manfred Rohde; Joe Pogliano; George Sakoulas; Victor Nizet
Journal:  J Antimicrob Chemother       Date:  2016-01-31       Impact factor: 5.790
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  10 in total

1.  The Effectiveness of Combination Therapy for Treating Methicillin-Susceptible Staphylococcus aureus Bacteremia: A Systematic Literature Review and a Meta-Analysis.

Authors:  Sara Grillo; Mireia Puig-Asensio; Marin L Schweizer; Guillermo Cuervo; Isabel Oriol; Miquel Pujol; Jordi Carratalà
Journal:  Microorganisms       Date:  2022-04-20

2.  Is the Success of Cefazolin plus Ertapenem in Methicillin-Susceptible Staphylococcus aureus Bacteremia Based on Release of Interleukin-1 Beta?

Authors:  Dan Smelter; Mary Hayney; George Sakoulas; Warren Rose
Journal:  Antimicrob Agents Chemother       Date:  2022-01-03       Impact factor: 5.938

3.  Vancomycin, Daptomycin, Antistaphylococcal β-Lactam, and Trimethoprim-Sulfamethoxazole Monotherapy and Combination Therapy in the Management of Methicillin-Resistant Staphylococcus aureus: A Network Meta-Analysis.

Authors:  Xiaonan Xu; Ni Lu; Pan Song; Mingzhen Zhou; Yuanxiao Li; Zirui Wang; Xin Gao
Journal:  Front Pharmacol       Date:  2022-05-17       Impact factor: 5.988

4.  Ticagrelor Increases Platelet-Mediated Staphylococcus aureus Killing, Resulting in Clearance of Bacteremia.

Authors:  Erlinda R Ulloa; Satoshi Uchiyama; Robert Gillespie; Victor Nizet; George Sakoulas
Journal:  J Infect Dis       Date:  2021-11-16       Impact factor: 5.226

5.  Potent Activity of Ertapenem Plus Cefazolin Within Staphylococcal Biofilms: A Contributing Factor in the Treatment of Methicillin-Susceptible Staphylococcus aureus Endocarditis.

Authors:  Jessica Gilbertie; Erlinda R Ulloa; Jennifer C Daiker; Khanh Nguyen; Dan Smelter; Warren Rose; Matthew Geriak; Lauren V Schnabel; Victor Nizet; George Sakoulas
Journal:  Open Forum Infect Dis       Date:  2022-03-23       Impact factor: 4.423

Review 6.  Infectious disease: how to manage Gram-positive and Gram-negative pathogen conundrums with dual beta-lactam therapy.

Authors:  Alireza FakhriRavari; Brenda Simiyu; Taylor Morrisette; Yewande Dayo; Jacinda C Abdul-Mutakabbir
Journal:  Drugs Context       Date:  2022-01-20

7.  Oxacillin plus ertapenem combination therapy leads to rapid blood culture clearance and positive outcomes among patients with persistent MSSA bacteraemia: a case series.

Authors:  Sami El-Dalati; Sanjay Sridaran; Marissa Uricchio; Ellen G Kline; Ryan Shields
Journal:  JAC Antimicrob Resist       Date:  2021-09-29

8.  Management of infective endocarditis in pregnancy by a multidisciplinary team: a case series.

Authors:  Kayle S Shapero; Varidhi Nauriyal; Christina Megli; Kathryn Berlacher; Sami El-Dalati
Journal:  Ther Adv Infect Dis       Date:  2022-02-24

9.  Persistent Methicillin-Susceptible Bacteremia Rapidly Cleared with Cefazolin and Ertapenem Combination Therapy in a Patient with COVID-19.

Authors:  Dan Ilges; Gayathri Krishnan; Elvin Geng
Journal:  Case Rep Infect Dis       Date:  2022-04-20

10.  Oxacillin plus ertapenem rapidly clears persistent left ventricular assist device-related methicillin-susceptible Staphylococcus aureus bacteremia.

Authors:  H Andrew Wilsey; Barbara Pisani; Thomas J O'Neill
Journal:  J Card Surg       Date:  2022-04-07       Impact factor: 1.778
  10 in total

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