Marco de Vincentiis1, Antonio Greco2, Flaminia Campo2,3, Francesca Candelori2, Massimo Ralli2, Mario Di Traglia4, Andrea Colizza5, Francesca Cambria2, Jacopo Zocchi3, Valentina Manciocco3, Giuseppe Spriano6, Raul Pellini3. 1. Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy. 2. Department of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, 00186, Rome, Italy. 3. Department of Otolaryngology-Head and Neck Surgery, IRCCS Regina Elena National Cancer Institute, Rome, Italy. 4. Department of Public Health and Infectious Diseases, Sapienza University, Rome, Italy. 5. Department of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, 00186, Rome, Italy. andrea.colizza@uniroma1.it. 6. Otorhinolaryngology Unit, Humanitas Clinical and Research Center-IRCCS, Rozzano, Milan, Italy.
Abstract
PURPOSE: The purpose of this study was to analyse the oncologic results of open partial horizontal laryngectomy (OPHL) and to assess the prognostic factors that could affect the survival of patients affected by T2, T3 and T4a laryngeal cancer. Using this data, we aim to identify clinical criteria to select patients amenable to conservative surgery, and to facilitate a more targeted approach in the management of advanced laryngeal cancer. METHODS: A retrospective study was performed in patients who underwent OPHL type II for laryngeal squamous cell carcinoma from January 2005 to December 2018. We analysed a total of 170 patients; 21(12.36%) cases were staged as pT2, 116 (68.23%) as pT3 and 33 (19.41%) as pT4a. RESULTS: Five-year overall survival (OS) was 80.9%, 79.3%, 70.4% for T2, T3 and T4 respectively. Disease-specific survival (DSS) was 90.4%, 85.3% and 77.4%. Posterior tumour extension, perineural invasion and N status showed to considerably influence survival in both uni- and multivariate analyses. CONCLUSION: The oncological outcomes from our study show that OPHL for advanced laryngeal cancer can guarantee a high percentage of success. Accurate patient selection is of utmost importance to differentiate advanced disease amenable to conservative surgery, and treatment options should consider selected criteria based on tumour and patient features.
PURPOSE: The purpose of this study was to analyse the oncologic results of open partial horizontal laryngectomy (OPHL) and to assess the prognostic factors that could affect the survival of patients affected by T2, T3 and T4a laryngeal cancer. Using this data, we aim to identify clinical criteria to select patients amenable to conservative surgery, and to facilitate a more targeted approach in the management of advanced laryngeal cancer. METHODS: A retrospective study was performed in patients who underwent OPHL type II for laryngeal squamous cell carcinoma from January 2005 to December 2018. We analysed a total of 170 patients; 21(12.36%) cases were staged as pT2, 116 (68.23%) as pT3 and 33 (19.41%) as pT4a. RESULTS: Five-year overall survival (OS) was 80.9%, 79.3%, 70.4% for T2, T3 and T4 respectively. Disease-specific survival (DSS) was 90.4%, 85.3% and 77.4%. Posterior tumour extension, perineural invasion and N status showed to considerably influence survival in both uni- and multivariate analyses. CONCLUSION: The oncological outcomes from our study show that OPHL for advanced laryngeal cancer can guarantee a high percentage of success. Accurate patient selection is of utmost importance to differentiate advanced disease amenable to conservative surgery, and treatment options should consider selected criteria based on tumour and patient features.
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Authors: Conor E Steuer; Mark El-Deiry; Jason R Parks; Kristin A Higgins; Nabil F Saba Journal: CA Cancer J Clin Date: 2016-11-29 Impact factor: 508.702
Authors: Giovanni Succo; Erika Crosetti; Andy Bertolin; Cesare Piazza; Gabriele Molteni; Stefano Cirillo; Massimo Petracchini; Martina Tascone; Andrea Elio Sprio; Giovanni Nicolao Berta; Giorgio Peretti; Livio Presutti; Giuseppe Rizzotto Journal: Head Neck Date: 2018-05-13 Impact factor: 3.147
Authors: Giuseppe Mercante; Alberto Grammatica; Paolo Battaglia; Giovanni Cristalli; Raul Pellini; Giuseppe Spriano Journal: Otolaryngol Head Neck Surg Date: 2013-08-06 Impact factor: 3.497
Authors: Andrea Colizza; Massimo Ralli; Arianna Di Stadio; Francesca Cambria; Federica Zoccali; Fabrizio Cialente; Diletta Angeletti; Antonio Greco; Marco de Vincentiis Journal: J Clin Med Date: 2022-08-14 Impact factor: 4.964