Giovanni Succo1, Erika Crosetti1, Andy Bertolin2, Cesare Piazza3, Gabriele Molteni4, Stefano Cirillo5, Massimo Petracchini5, Martina Tascone1, Andrea Elio Sprio6, Giovanni Nicolao Berta6, Giorgio Peretti7, Livio Presutti4, Giuseppe Rizzotto2. 1. Head and Neck Oncology Service, Oncology Department, University of Turin, Candiolo Cancer Institute - FPO, IRCCS, Candiolo (To), Italy. 2. Otolaryngology Service, Vittorio Veneto Hospital, Vittorio Veneto, Treviso, Italy. 3. Department of Otorhinolaryngology - Head and Neck Surgery, University of Brescia, Brescia, Italy. 4. Otolaryngology Service, Head and Neck Department, Policlinico Hospital, University of Modena, Italy. 5. Radiology Service, Mauriziano Umberto I Hospital, Turin, Italy. 6. Department of Clinical and Biological Sciences, University of Turin, Italy. 7. Department of Otorhinolaryngology - Head and Neck Surgery, University of Genoa, Genoa, Italy.
Abstract
BACKGROUND: The purpose of this retrospective study was to identify subcategories in cT3 to cT4a supraglottic/glottic cancers, describing their different spreading patterns, and local and locoregional recurrence modes. METHODS: Four hundred eighty-nine patients who underwent open partial horizontal laryngectomies (OPHLs) were retrospectively classified as: subcategory I (anterior pT3 with normal arytenoid mobility); subcategory II (posterior pT3 with impaired/absent mobility); subcategory III (anterior pT4 with normal mobility); and subcategory IV (posterior pT4 with impaired/absent mobility). RESULTS: Five-year overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), locoregional, local control, freedom from laryngectomy, and laryngectomy-free survival were significantly better in anterior tumors (subcategories I and III) when compared with the corresponding posterior ones (subcategories II and IV). CONCLUSION: Anterior cT3 tumors are manageable by OPHL, and this approach could also be proposed in the treatment of early anterior cT4aN0. Despite promising results, OPHLs should be considered under investigation in posterior cT3 tumors due to clinical and biological behavior similar to cT4a tumors.
BACKGROUND: The purpose of this retrospective study was to identify subcategories in cT3 to cT4a supraglottic/glottic cancers, describing their different spreading patterns, and local and locoregional recurrence modes. METHODS: Four hundred eighty-nine patients who underwent open partial horizontal laryngectomies (OPHLs) were retrospectively classified as: subcategory I (anterior pT3 with normal arytenoid mobility); subcategory II (posterior pT3 with impaired/absent mobility); subcategory III (anterior pT4 with normal mobility); and subcategory IV (posterior pT4 with impaired/absent mobility). RESULTS: Five-year overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), locoregional, local control, freedom from laryngectomy, and laryngectomy-free survival were significantly better in anterior tumors (subcategories I and III) when compared with the corresponding posterior ones (subcategories II and IV). CONCLUSION: Anterior cT3tumors are manageable by OPHL, and this approach could also be proposed in the treatment of early anterior cT4aN0. Despite promising results, OPHLs should be considered under investigation in posterior cT3tumors due to clinical and biological behavior similar to cT4a tumors.
Authors: Andy Bertolin; Marco Lionello; Marco Ghizzo; Emanuela Barbero; Erika Crosetti; Giuseppe Rizzotto; Giovanni Succo Journal: Acta Otorhinolaryngol Ital Date: 2020-10 Impact factor: 2.124
Authors: Marco Lucioni; Marco Lionello; Francesco Guida; Federica Sovran; Fabio Canal; Giuseppe Rizzotto; Andy Bertolin Journal: Acta Otorhinolaryngol Ital Date: 2020-04 Impact factor: 2.124
Authors: E Crosetti; A Bertolin; G Molteni; I Bertotto; D Balmativola; M Carraro; A E Sprio; G N Berta; L Presutti; G Rizzotto; G Succo Journal: Acta Otorhinolaryngol Ital Date: 2019-08 Impact factor: 2.124
Authors: Martine Hendriksma; Marc A P van Ruler; Berit M Verbist; Martin A de Jong; Ton P M Langeveld; Peter Paul G van Benthem; Elisabeth V Sjögren Journal: Cancers (Basel) Date: 2019-09-06 Impact factor: 6.639