INTRODUCTION: Education, and less frequently occupation, has been associated with lower dementia risk in studies from high-income countries. We aimed to investigate the association of cognitive impairment with education and occupation in a low-middle-income country sample. METHODS: In this cross-sectional study, cognitive function was assessed by the Clinical Dementia Rating sum of boxes (CDR-SOB). We investigated the association of occupation complexity and education with CDR-SOB using adjusted linear regression models for age, sex, and neuropathological lesions. RESULTS: In 1023 participants, 77% had < 5 years of education, and 56% unskilled occupations. Compared to the group without education, those with formal education had lower CDR-SOB (1-4 years: β = -0.99, 95% confidence interval [CI] = -1.85; -0.14, P = .02; ≥5 years: β = -1.42, 95% CI = -2.47; -0.38, P = .008). Occupation complexity and demands were unrelated to cognition. DISCUSSION: Education, but not occupation, was related to better cognitive abilities independent of the presence of neuropathological insults.
INTRODUCTION: Education, and less frequently occupation, has been associated with lower dementia risk in studies from high-income countries. We aimed to investigate the association of cognitive impairment with education and occupation in a low-middle-income country sample. METHODS: In this cross-sectional study, cognitive function was assessed by the Clinical Dementia Rating sum of boxes (CDR-SOB). We investigated the association of occupation complexity and education with CDR-SOB using adjusted linear regression models for age, sex, and neuropathological lesions. RESULTS: In 1023 participants, 77% had < 5 years of education, and 56% unskilled occupations. Compared to the group without education, those with formal education had lower CDR-SOB (1-4 years: β = -0.99, 95% confidence interval [CI] = -1.85; -0.14, P = .02; ≥5 years: β = -1.42, 95% CI = -2.47; -0.38, P = .008). Occupation complexity and demands were unrelated to cognition. DISCUSSION: Education, but not occupation, was related to better cognitive abilities independent of the presence of neuropathological insults.
Authors: Heiko Braak; Kelly Del Tredici; Udo Rüb; Rob A I de Vos; Ernst N H Jansen Steur; Eva Braak Journal: Neurobiol Aging Date: 2003 Mar-Apr Impact factor: 4.673
Authors: C Helmer; L Letenneur; I Rouch; S Richard-Harston; P Barberger-Gateau; C Fabrigoule; J M Orgogozo; J F Dartigues Journal: J Neurol Neurosurg Psychiatry Date: 2001-09 Impact factor: 10.154
Authors: Jose Marcelo Farfel; Ricardo Nitrini; Claudia Kimie Suemoto; Lea Tenenholz Grinberg; Renata Eloah Lucena Ferretti; Renata Elaine Paraizo Leite; Edilaine Tampellini; Luzia Lima; Daniela Souza Farias; Ricardo Caires Neves; Roberta Diehl Rodriguez; Paulo Rossi Menezes; Felipe Fregni; David A Bennett; Carlos Augusto Pasqualucci; Wilson Jacob Filho Journal: Neurology Date: 2013-07-19 Impact factor: 9.910
Authors: Robert S Wilson; Lei Yu; Melissa Lamar; Julie A Schneider; Patricia A Boyle; David A Bennett Journal: Neurology Date: 2019-02-06 Impact factor: 9.910
Authors: Martin Prince; Daisy Acosta; Cleusa P Ferri; Mariella Guerra; Yueqin Huang; Juan J Llibre Rodriguez; Aquiles Salas; Ana Luisa Sosa; Joseph D Williams; Michael E Dewey; Isaac Acosta; Amuthavalli T Jotheeswaran; Zhaorui Liu Journal: Lancet Date: 2012-05-23 Impact factor: 79.321
Authors: Claudia K Suemoto; Renata E L Ferretti-Rebustini; Roberta D Rodriguez; Renata E P Leite; Luciana Soterio; Sonia M D Brucki; Raphael R Spera; Tarcila M Cippiciani; Jose M Farfel; Alexandre Chiavegatto Filho; Michel Satya Naslavsky; Mayana Zatz; Carlos A Pasqualucci; Wilson Jacob-Filho; Ricardo Nitrini; Lea T Grinberg Journal: PLoS Med Date: 2017-03-28 Impact factor: 11.069