Jane Anastassopoulou1, Vasiliki Mamareli2, Evangelos Mylonas3, Panagiota Kolovou4, Ioannis Mamarelis5, Christophoros Kotoulas5, Christina Mamareli6, Sotiris Kotoulas7, Emmanouil Koutoulakis8, Konstantinos Spiliopoulos3, Theophile Theophanides2. 1. Radiation Chemistry and Biospectroscopy, Chemical Engineering School, National Technical University of Athens, Athens, Greece; i.anastassopoulou@gmail.com. 2. Radiation Chemistry and Biospectroscopy, Chemical Engineering School, National Technical University of Athens, Athens, Greece. 3. Institute of Structural Analysis and Antiseismic Research, National Technical University of Athens, Athens, Greece. 4. High-Resolution Echo Diagnostic Center, Karditsa, Greece. 5. Cardiology Department, 401 General Army Hospital of Athens, Athens, Greece. 6. Emergency Department, Vostanio General Hospital of Mytilene, Lesvos, Greece. 7. Cardiothoracic Surgery Department, Metropolitan General Hospital of Athens, Athens, Greece. 8. Department of Cardiology, NIMTS Veteran Hospital of Athens, Athens, Greece.
Abstract
BACKGROUND/AIM: The pathogenesis, treatment and prevention of atherosclerosis continue to be the subject of intensive research and study by the scientific community. Based on Fourier-transform infrared spectra and 3D-Doppler echogram, we attempted to develop a computational simulation model for predicting the association of atherosclerotic risk factors with pathogenic molecular structural changes. MATERIALS AND METHODS: Atheromatic carotid arteries from 56 patients (60-85 years old) were used as samples. Color 3D-Doppler echogram screening was performed on all patients preoperatively. Each infrared spectrum consisted of 120 co-added spectra at a spectral resolution of 4 cm-1 Results: The infrared spectral analysis reveals 'marker bands', such as the 1,744 cm-1 band assigned to aldehyde formation and to the 'fingerprint' digital spectral region of 1,050-1,169 cm-1, characteristic of the presence of advanced glycation end products (C-O-C). The accumulation of calcium phosphate salts increases the formation rate of stenosis. The critical point of stenosis risk starts at about 45%, while when stenosis is over 60-70%, the risk of ischemic stroke or other major adverse cardiovascular events increases dramatically. CONCLUSION: Fourier-transform infrared spectroscopy and mathematical simulation models showed that carotid artery stenosis over 45% reduces the blood flow rate, while stenosis over 65% dramatically increases the hemodynamic disturbance, with a parallel increase the rate of ischemic stroke or other major adverse cardiovascular events.
BACKGROUND/AIM: The pathogenesis, treatment and prevention of atherosclerosis continue to be the subject of intensive research and study by the scientific community. Based on Fourier-transform infrared spectra and 3D-Doppler echogram, we attempted to develop a computational simulation model for predicting the association of atherosclerotic risk factors with pathogenic molecular structural changes. MATERIALS AND METHODS: Atheromatic carotid arteries from 56 patients (60-85 years old) were used as samples. Color 3D-Doppler echogram screening was performed on all patients preoperatively. Each infrared spectrum consisted of 120 co-added spectra at a spectral resolution of 4 cm-1 Results: The infrared spectral analysis reveals 'marker bands', such as the 1,744 cm-1 band assigned to aldehyde formation and to the 'fingerprint' digital spectral region of 1,050-1,169 cm-1, characteristic of the presence of advanced glycation end products (C-O-C). The accumulation of calcium phosphate salts increases the formation rate of stenosis. The critical point of stenosis risk starts at about 45%, while when stenosis is over 60-70%, the risk of ischemic stroke or other major adverse cardiovascular events increases dramatically. CONCLUSION: Fourier-transform infrared spectroscopy and mathematical simulation models showed that carotid artery stenosis over 45% reduces the blood flow rate, while stenosis over 65% dramatically increases the hemodynamic disturbance, with a parallel increase the rate of ischemic stroke or other major adverse cardiovascular events.
Authors: Julyan H E Cartwright; Antonio G Checa; Julian D Gale; Denis Gebauer; C Ignacio Sainz-Díaz Journal: Angew Chem Int Ed Engl Date: 2012-11-04 Impact factor: 15.336
Authors: Leonardo Lorente; María M Martín; Pedro Abreu-González; Rafael Sabatel; Luis Ramos; Mónica Argueso; Jordi Solé-Violán; Juan J Cáceres; Alejandro Jiménez; Victor García-Marín Journal: BMC Neurol Date: 2019-10-17 Impact factor: 2.474