Dragos Serban1,2, Daniel Ovidiu Costea3,4, Anca Zgura5,6, Mihail Silviu Tudosie7,8, Ana Maria Dascalu9,10, Gabriel Andrei Gangura1,11, Catalin Gabriel Smarandache1,2, Alexandru Dan Sabau12,13, Corneliu Tudor2, Mihai Faur12,13, Andreea Cristina Costea14, Daniela Stana10, Simona Andreea Balasescu2, Laura Carina Tribus15,16, Ciprian Tanasescu12,13. 1. Faculty of Medicine, Department of General Surgery 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania. 2. IV Department of Surgery, Emergency University Hospital, Bucharest, Romania. 3. Faculty of Medicine, Department of Clinical Surgical Disciplines I 'Ovidius' University, Constanta, Romania. 4. First Surgery Department, Emergency County Hospital, Constanta, Romania. 5. Department of Oncology, Radiology and Hematology, Faculty of Medicine, 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania. 6. Department of Oncology Radiotherapy, Institute of Oncology 'Prof. Dr. Alexandru Trestioreanu', Bucharest, Romania. 7. Department of Orthopedia and Intensive care, Faculty of Medicine, 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania. 8. ICU II Toxicology, Clinical Emergency Hospital, Bucharest, Romania. 9. Department of ENT-Ophthalmology, Faculty of Medicine, 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania; ana.dascalu@umfcd.ro. 10. Ophthalmology Department, Emergency University Hospital, Bucharest, Romania. 11. 2 Department of Surgery, Emergency University Hospital, Bucharest, Romania. 12. Surgical Clinical Department, Faculty of Medicine, 'Lucian Blaga' University, Sibiu, Romania. 13. Department of Surgery, Sibiu County Emergency Clinical Hospital, Sibiu, Romania. 14. Nephrology and Dialysis Department, 'Diaverum' Clinic, Constanta, Romania. 15. Faculty of Medicine, Department of Internal Medicine Gastroenterology, 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania. 16. Gastroenterology Department, Emergency University Hospital Bucharest, Bucharest, Romania.
Abstract
BACKGROUND: Aromatase inhibitor therapy is currently the preferred choice in postmenopausal women with estrogen receptor positive breast cancer. This article reviews the ocular side effects of treatment with aromatase inhibitors (AIs) in patients with breast cancer. MATERIALS AND METHODS: A comprehensive search was performed on PubMed, Web of Science and Google scholar. RESULTS: After duplication removal, 14 clinical studies and 5 case reports, published between 2008 and 2021, were identified. Most frequently, AI treatment resulted in minor to moderate dry eye symptoms. "De novo" onset of Sjogren syndrome during AI therapy was also reported. Retinal and optic nerve side effects varied from mild, subclinical anatomic and functional impairment to severe decreased vision, secondary to hemi-central retinal artery occlusion, bilateral optic neuritis or uveitis with bilateral macular edema. CONCLUSION: Visual disturbances encountered during AI treatment may be underestimated. Ophthalmic screening is important for early detection and appropriate treatment.
BACKGROUND: Aromatase inhibitor therapy is currently the preferred choice in postmenopausal women with estrogen receptor positive breast cancer. This article reviews the ocular side effects of treatment with aromatase inhibitors (AIs) in patients with breast cancer. MATERIALS AND METHODS: A comprehensive search was performed on PubMed, Web of Science and Google scholar. RESULTS: After duplication removal, 14 clinical studies and 5 case reports, published between 2008 and 2021, were identified. Most frequently, AI treatment resulted in minor to moderate dry eye symptoms. "De novo" onset of Sjogren syndrome during AI therapy was also reported. Retinal and optic nerve side effects varied from mild, subclinical anatomic and functional impairment to severe decreased vision, secondary to hemi-central retinal artery occlusion, bilateral optic neuritis or uveitis with bilateral macular edema. CONCLUSION: Visual disturbances encountered during AI treatment may be underestimated. Ophthalmic screening is important for early detection and appropriate treatment.
Authors: Oscar Jim Michael Coppes; Rimas V Lukas; Gini F Fleming; Jeffrey Nichols; Meaghan Tenney; Jacqueline Bernard Journal: Neuroophthalmology Date: 2014-09-19
Authors: Kiran Turaka; Jennifer M Nottage; Kristin M Hammersmith; Parveen K Nagra; Christopher J Rapuano Journal: Clin Exp Ophthalmol Date: 2012-11-06 Impact factor: 4.207