| Literature DB >> 3497140 |
G Seibert, D Isert, N Klesel, M Limbert, A Pries, E Schrinner, M Cooke, J Walmsley, P H Bentley.
Abstract
The new penem antibiotic HRE 664 displays potent antibacterial activity in vitro against a broad spectrum of clinically relevant bacterial strains including Gram-negative and Gram-positive aerobes and anaerobes. With an MIC 90% of 0.43 micrograms/ml, it is also active against methicillin-resistant staphylococci. HRE 664 is extremely stable against beta-lactamases, it binds preferentially to the penicillin-binding proteins 2, 3, 5 and 6 of Escherichia coli.Entities:
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Year: 1987 PMID： 3497140 DOI： 10.7164/antibiotics.40.660
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649