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Literature DB >> 3190195

Antibacterial activity of HRE 664, a new parenteral penem.

Abstract

The antibacterial activity of the new penem compound HRE 664 was evaluated in 451 clinical isolates, including ampicillin-resistant members of the family Enterobacteriaceae, Acinetobacter spp., Haemophilus influenzae, Staphylococcus aureus, and beta-hemolytic streptococci, and compared with those of piperacillin, ceftazidime, ceftriaxone, aztreonam, imipenem, and the penem compound Sch 34343. The new agent HRE 664 exhibited antibacterial activity comparable to that of the penem Sch 34343 and imipenem. The MICs of the new agent HRE 664 for 90% of the strains tested ranged from 1 to 4 micrograms/ml against Enterobacteriaceae and were 0.06 micrograms/ml for Staphylococcus aureus and 0.125 micrograms/ml for beta-hemolytic streptococci.

Entities: Chemical Species

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Year: 1988 PMID： 3190195 PMCID： PMC172351 DOI： 10.1128/AAC.32.7.1090

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

9 in total

1 in total

1. Use of the chromosomal class A beta-lactamase of Mycobacterium fortuitum D316 to study potentially poor substrates and inhibitory beta-lactam compounds.

Authors: M Galleni; N Franceschini; B Quinting; L Fattorini; G Orefici; A Oratore; J M Frère; G Amicosante
Journal: Antimicrob Agents Chemother Date: 1994-07 Impact factor: 5.191

1 in total

Antibacterial activity of HRE 664, a new parenteral penem.

1. The detection of methicillin resistance in Staphylococcus aureus.

2. HRE 664, a new parenteral penem. I. Antibacterial activity in vitro.

3. Sch 29482--a novel penem antibiotic: an in-vitro comparison of its activity with other beta-lactams.

4. Sch 29482: in-vitro antibacterial activity and susceptibility to beta-lactamases.

5. Synthesis of Sch 29482--a novel penem antibiotic.

6. In vitro activity of CGP 31608, a new penem.

7. Sch 34343: in-vitro antibacterial activity and susceptibility to beta-lactamases.

8. In-vitro evaluation of Sch 34343: antimicrobial activity, beta-lactamase stability and inhibition.

9. In vitro activity and beta-lactamase stability of a new penem, CGP 31608.

1. Use of the chromosomal class A beta-lactamase of Mycobacterium fortuitum D316 to study potentially poor substrates and inhibitory beta-lactam compounds.