Amanda Benavides1, Edward F Bell2, Amy L Conrad2, Henry A Feldman3, Michael K Georgieff4, Cassandra D Josephson5, Timothy R Koscik6, Sean R Stowell7, Martha Sola-Visner3, Peg Nopoulos8. 1. Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA. Electronic address: amanda-benavides@uiowa.edu. 2. Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA. 3. Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA. 4. Division of Neonatology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN. 5. Department of Pediatrics, Emory University School of Medicine and Aflac Cancer Center and Blood Disorders Service, Children's Healthcare of Atlanta, Atlanta, GA; Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA. 6. Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA. 7. Department of Pathology, Joint Program in Transfusion Medicine Brigham and Women's Hospital, Harvard Medical School, Boston, MA. 8. Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA; Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA; Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA.
Abstract
OBJECTIVE: To assess sex-specific differences in early brain structure and function of preterm infants after red blood cell (RBC) transfusions. STUDY DESIGN: A single-center subset of infants with a birth weight <1000 g and gestational age 22-29 weeks were enrolled from the National Institute of Child Health and Human Development's Neonatal Research Network Transfusion of Prematures Trial. Hemoglobin (Hb) concentration obtained directly before each transfusion (pretransfusion Hb [ptHb]) was obtained longitudinally throughout each infant's neonatal intensive care unit stay and used as a marker of degree of anemia (n = 97). Measures of regional brain volumes using magnetic resonance imaging were obtained at ∼40 weeks postmenstrual age or at hospital discharge, if earlier (n = 29). Measures of brain function were obtained at 12 months corrected age using the Bayley Scales of Infant & Toddler Development, 3rd Edition (n = 34). RESULTS: PtHb was positively correlated with neonatal cerebral white matter volume in males (B = +0.283; P = .006), but not females (B = -0.099; P = .713), resulting in a significant sex interaction (P = .010). Bayley-III gross motor scores and a pooled mean score were significantly lower in association with higher ptHb in females (gross motor score: B = -3.758; P = .013; pooled mean score: B = -1.225; P = .030), but not males (gross motor score: B = +1.758; P = .167; pooled mean score: B = +0.621; P = .359). Higher ptHb was associated with descriptively lower performance on multiple Bayley-III subscales in females, but not in males. CONCLUSIONS: This study demonstrates sex-specific associations between an early marker of anemia and RBC transfusion status (ie, ptHb) with both neonatal white matter volume and early cognitive function at age 12 months in preterm infants. Published by Elsevier Inc.
OBJECTIVE: To assess sex-specific differences in early brain structure and function of preterm infants after red blood cell (RBC) transfusions. STUDY DESIGN: A single-center subset of infants with a birth weight <1000 g and gestational age 22-29 weeks were enrolled from the National Institute of Child Health and Human Development's Neonatal Research Network Transfusion of Prematures Trial. Hemoglobin (Hb) concentration obtained directly before each transfusion (pretransfusion Hb [ptHb]) was obtained longitudinally throughout each infant's neonatal intensive care unit stay and used as a marker of degree of anemia (n = 97). Measures of regional brain volumes using magnetic resonance imaging were obtained at ∼40 weeks postmenstrual age or at hospital discharge, if earlier (n = 29). Measures of brain function were obtained at 12 months corrected age using the Bayley Scales of Infant & Toddler Development, 3rd Edition (n = 34). RESULTS: PtHb was positively correlated with neonatal cerebral white matter volume in males (B = +0.283; P = .006), but not females (B = -0.099; P = .713), resulting in a significant sex interaction (P = .010). Bayley-III gross motor scores and a pooled mean score were significantly lower in association with higher ptHb in females (gross motor score: B = -3.758; P = .013; pooled mean score: B = -1.225; P = .030), but not males (gross motor score: B = +1.758; P = .167; pooled mean score: B = +0.621; P = .359). Higher ptHb was associated with descriptively lower performance on multiple Bayley-III subscales in females, but not in males. CONCLUSIONS: This study demonstrates sex-specific associations between an early marker of anemia and RBC transfusion status (ie, ptHb) with both neonatal white matter volume and early cognitive function at age 12 months in preterm infants. Published by Elsevier Inc.
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