Literature DB >> 26120961

Different immune cells mediate mechanical pain hypersensitivity in male and female mice.

Robert E Sorge1, Josiane C S Mapplebeck2, Sarah Rosen3, Simon Beggs4, Sarah Taves5, Jessica K Alexander4, Loren J Martin3, Jean-Sebastien Austin3, Susana G Sotocinal3, Di Chen3, Mu Yang6, Xiang Qun Shi6, Hao Huang6, Nicolas J Pillon7, Philip J Bilan7, YuShan Tu8, Amira Klip7, Ru-Rong Ji5, Ji Zhang9, Michael W Salter4, Jeffrey S Mogil10.   

Abstract

A large and rapidly increasing body of evidence indicates that microglia-to-neuron signaling is essential for chronic pain hypersensitivity. Using multiple approaches, we found that microglia are not required for mechanical pain hypersensitivity in female mice; female mice achieved similar levels of pain hypersensitivity using adaptive immune cells, likely T lymphocytes. This sexual dimorphism suggests that male mice cannot be used as proxies for females in pain research.

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Year:  2015        PMID： 26120961      PMCID： PMC4772157          DOI： 10.1038/nn.4053

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  26 in total

1.  Peroxisome proliferator-activated receptor (PPAR)α and -γ regulate IFNγ and IL-17A production by human T cells in a sex-specific way.

Authors:  Monan Angela Zhang; Dorothy Rego; Marina Moshkova; Hania Kebir; Andrzej Chruscinski; Hoangkim Nguyen; Rainer Akkermann; Frank Z Stanczyk; Alexandre Prat; Lawrence Steinman; Shannon E Dunn
Journal:  Proc Natl Acad Sci U S A       Date:  2012-05-30       Impact factor: 11.205

2.  Sex-specific mediation of opioid-induced hyperalgesia by the melanocortin-1 receptor.

Authors:  Aaron Juni; Minying Cai; Magda Stankova; Amanda R Waxman; Caroline Arout; Gad Klein; Albert Dahan; Victor J Hruby; Jeffrey S Mogil; Benjamin Kest
Journal:  Anesthesiology       Date:  2010-01       Impact factor: 7.892

3.  Interleukin-17 contributes to neuroinflammation and neuropathic pain following peripheral nerve injury in mice.

Authors:  Cristina Fabiola Kim; Gila Moalem-Taylor
Journal:  J Pain       Date:  2011-03       Impact factor: 5.820

4.  BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain.

Authors:  Jeffrey A M Coull; Simon Beggs; Dominic Boudreau; Dominick Boivin; Makoto Tsuda; Kazuhide Inoue; Claude Gravel; Michael W Salter; Yves De Koninck
Journal:  Nature       Date:  2005-12-15       Impact factor: 49.962

5.  Olfactory exposure to males, including men, causes stress and related analgesia in rodents.

Authors:  Robert E Sorge; Loren J Martin; Kelsey A Isbester; Susana G Sotocinal; Sarah Rosen; Alexander H Tuttle; Jeffrey S Wieskopf; Erinn L Acland; Anastassia Dokova; Basil Kadoura; Philip Leger; Josiane C S Mapplebeck; Martina McPhail; Ada Delaney; Gustaf Wigerblad; Alan P Schumann; Tammie Quinn; Johannes Frasnelli; Camilla I Svensson; Wendy F Sternberg; Jeffrey S Mogil
Journal:  Nat Methods       Date:  2014-04-28       Impact factor: 28.547

6.  Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.

Authors:  Christopher N Parkhurst; Guang Yang; Ipe Ninan; Jeffrey N Savas; John R Yates; Juan J Lafaille; Barbara L Hempstead; Dan R Littman; Wen-Biao Gan
Journal:  Cell       Date:  2013-12-19       Impact factor: 41.582

7.  Assessment and analysis of mechanical allodynia-like behavior induced by spared nerve injury (SNI) in the mouse.

Authors:  Anne-Frédérique Bourquin; Maria Süveges; Marie Pertin; Nicolas Gilliard; Sylvain Sardy; Anthony C Davison; Donat R Spahn; Isabelle Decosterd
Journal:  Pain       Date:  2006-03-20       Impact factor: 6.961

8.  Sex differences in the antagonism of swim stress-induced analgesia: effects of gonadectomy and estrogen replacement.

Authors:  Jeffrey S Mogil; Wendy F Sternberg; Benjamin Kest; Przemyslaw Marek; John C Liebeskind
Journal:  Pain       Date:  1993-04       Impact factor: 6.961

9.  P2X4R+ microglia drive neuropathic pain.

Authors:  Simon Beggs; Tuan Trang; Michael W Salter
Journal:  Nat Neurosci       Date:  2012-07-26       Impact factor: 24.884

10.  p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain.

Authors:  Shan-Xue Jin; Zhi-Ye Zhuang; Clifford J Woolf; Ru-Rong Ji
Journal:  J Neurosci       Date:  2003-05-15       Impact factor: 6.167
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  411 in total

1.  Solving for (se)x.

Authors:  Brigitta B Gundersen
Journal:  Lab Anim (NY)       Date:  2015-10       Impact factor: 12.625

2.  Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: Sex-dependent microglial signaling in the spinal cord.

Authors:  Sarah Taves; Temugin Berta; Da-Lu Liu; Sophie Gan; Gang Chen; Yong Ho Kim; Thomas Van de Ven; Stefan Laufer; Ru-Rong Ji
Journal:  Brain Behav Immun       Date:  2015-10-19       Impact factor: 7.217

Review 3.  Cellular and molecular mechanisms of sexual differentiation in the mammalian nervous system.

Authors:  Nancy G Forger; J Alex Strahan; Alexandra Castillo-Ruiz
Journal:  Front Neuroendocrinol       Date:  2016-01-11       Impact factor: 8.606

Review 4.  Multifaceted origins of sex differences in the brain.

Authors:  Margaret M McCarthy
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2016-02-01       Impact factor: 6.237

5.  Regulation of Expression of Hyperalgesic Priming by Estrogen Receptor α in the Rat.

Authors:  Luiz F Ferrari; Dionéia Araldi; Jon D Levine
Journal:  J Pain       Date:  2017-01-09       Impact factor: 5.820

6.  Recent advances toward understanding the mysteries of the acute to chronic pain transition.

Authors:  Theodore J Price; Pradipta R Ray
Journal:  Curr Opin Physiol       Date:  2019-06-04

7.  Up-Regulation of CX3CL1 via STAT3 Contributes to SMIR-Induced Chronic Postsurgical Pain.

Authors:  Yijia Shen; Dai Li; Bo Li; Peng Xi; Yun Zhang; Youshui Jiang; Yehao Xu; Hui Chen; Yuanchang Xiong
Journal:  Neurochem Res       Date:  2018-01-08       Impact factor: 3.996

8.  Adenosine A3 agonists reverse neuropathic pain via T cell-mediated production of IL-10.

Authors:  Mariaconcetta Durante; Silvia Squillace; Filomena Lauro; Luigino Antonio Giancotti; Elisabetta Coppi; Federica Cherchi; Lorenzo Di Cesare Mannelli; Carla Ghelardini; Grant Kolar; Carrie Wahlman; Adeleye Opejin; Cuiying Xiao; Marc L Reitman; Dilip K Tosh; Daniel Hawiger; Kenneth A Jacobson; Daniela Salvemini
Journal:  J Clin Invest       Date:  2021-04-01       Impact factor: 14.808

9.  Hormonal and molecular effects of restraint stress on formalin-induced pain-like behavior in male and female mice.

Authors:  Caela C Long; Katelyn E Sadler; Benedict J Kolber
Journal:  Physiol Behav       Date:  2016-08-09

10.  Access to a high resource environment protects against accelerated maturation following early life stress: A translational animal model of high, medium and low security settings.

Authors:  Arielle R Strzelewicz; Evelyn Ordoñes Sanchez; Alejandro N Rondón-Ortiz; Anthony Raneri; Sydney T Famularo; Debra A Bangasser; Amanda C Kentner
Journal:  Horm Behav       Date:  2019-03-02       Impact factor: 3.587
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