Julia E Heck1,2, Chia-Kai Wu3, Xiwen Huang2, Kara W Chew4, Myron Tong5, Noah Federman6, Beate Ritz7, Onyebuchi A Arah7,8,9, Chung-Yi Li10,11, Fei Yu12, Jorn Olsen13, Johnni Hansen14, Pei-Chen Lee3,15,16. 1. Department of Rehabilitation and Health Services, College of Health and Public Service, University of North Texas, Denton, TX, USA. 2. Center for Racial and Ethnic Equity in Health and Society, University of North Texas, Denton, TX, USA. 3. Department of Health Care Management, National Taipei University of Nursing and Health Sciences, Beitou Dist, Taipei, Taiwan. 4. Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. 5. Asian Liver Center, Geffen School of Medicine and Ronald Reagan Medical Center, UCLA, Los Angeles, CA, USA. 6. Department of Pediatrics, Geffen School of Medicine, UCLA, Los Angeles, CA, USA. 7. Department of Epidemiology, Fielding School of Public Health, University of California (UCLA), Los Angeles, CA, USA. 8. Department of Statistics, UCLA College of Letters and Science, Los Angeles, CA, USA. 9. Department of Public Health, Faculty of Health, Aarhus University, Aarhus, Denmark. 10. Department of Public Health, National Cheng Kung University, Tainan, Taiwan. 11. Department of Public Health, College of Public Health, China Medical University, Taichung, Taiwan. 12. Department of Biostatistics, Fielding School of Public Health UCLA, Los Angeles, CA, USA. 13. Department of Clinical Epidemiology, Aarhus University, Aarhus N, Denmark. 14. Danish Cancer Society Research Center, Copenhagen, Denmark. 15. Department of Psychiatry, Taipei City Hospital, Taipei, Taiwan. 16. Inserm U1018, Team 'Exposome, Heredity, Cancer and Health', CESP, Villejuif, France.
Abstract
BACKGROUND: Although viral hepatitis causes paediatric hepatocellular carcinoma and hepatic and extrahepatic cancers in adults, there are few epidemiologic studies on paediatric-cancer risks from parental viral hepatitis. In a nationwide study in a viral hepatitis endemic region and with confirmation in another population-based sample, we examined associations between parental hepatitis B (HBV) and C (HCV) infections and risks of cancers in offspring. METHODS: We included all children born in Taiwan in 2004-2014 (N = 2 079 037) with 2160 cancer cases ascertained from the Cancer Registry. We estimated risks for paediatric cancers using Cox proportional-hazard regressions. We checked these associations in a nationwide case-control study in Denmark (6422 cases, 160 522 controls). RESULTS: In Taiwan, paternal HBV was related to child's hepatoblastoma [hazard ratio (HR) = 1.77, 95% confidence interval (CI) = 1.05, 2.97] when identified at any time in the medical record, and when analyses were limited to hepatitis diagnoses occurring before the child's birth, risks increased (HR = 2.08, 95% CI = 1.13-3.80). Paternal HCV was related to child's non-Hodgkin lymphoma (HR = 2.06, 95% CI = 1.13-3.74). Maternal HCV was weakly related to increased risks of all childhood cancers [all types combined; HR = 1.45, 95% CI = 0.95-2.22]. The population-attributable fraction of hepatoblastoma for maternal, paternal and child HBV was 2.6%, 6.8% and 2.8%, respectively. CONCLUSIONS: Parental HBV and HCV may be risk factors for hepatic and non-hepatic cancers in children. If associations are causal, then parental screening and treatment with antivirals may prevent some paediatric cancers.
BACKGROUND: Although viral hepatitis causes paediatric hepatocellular carcinoma and hepatic and extrahepatic cancers in adults, there are few epidemiologic studies on paediatric-cancer risks from parental viral hepatitis. In a nationwide study in a viral hepatitis endemic region and with confirmation in another population-based sample, we examined associations between parental hepatitis B (HBV) and C (HCV) infections and risks of cancers in offspring. METHODS: We included all children born in Taiwan in 2004-2014 (N = 2 079 037) with 2160 cancer cases ascertained from the Cancer Registry. We estimated risks for paediatric cancers using Cox proportional-hazard regressions. We checked these associations in a nationwide case-control study in Denmark (6422 cases, 160 522 controls). RESULTS: In Taiwan, paternal HBV was related to child's hepatoblastoma [hazard ratio (HR) = 1.77, 95% confidence interval (CI) = 1.05, 2.97] when identified at any time in the medical record, and when analyses were limited to hepatitis diagnoses occurring before the child's birth, risks increased (HR = 2.08, 95% CI = 1.13-3.80). Paternal HCV was related to child's non-Hodgkin lymphoma (HR = 2.06, 95% CI = 1.13-3.74). Maternal HCV was weakly related to increased risks of all childhood cancers [all types combined; HR = 1.45, 95% CI = 0.95-2.22]. The population-attributable fraction of hepatoblastoma for maternal, paternal and child HBV was 2.6%, 6.8% and 2.8%, respectively. CONCLUSIONS: Parental HBV and HCV may be risk factors for hepatic and non-hepatic cancers in children. If associations are causal, then parental screening and treatment with antivirals may prevent some paediatric cancers.
Authors: Kimberly J Johnson; Jennifer Cullen; Jill S Barnholtz-Sloan; Quinn T Ostrom; Chelsea E Langer; Michelle C Turner; Roberta McKean-Cowdin; James L Fisher; Philip J Lupo; Sonia Partap; Judith A Schwartzbaum; Michael E Scheurer Journal: Cancer Epidemiol Biomarkers Prev Date: 2014-09-05 Impact factor: 4.254
Authors: H M Hsu; D S Chen; C H Chuang; J C Lu; D M Jwo; C C Lee; H C Lu; S H Cheng; Y F Wang; C Y Wang Journal: JAMA Date: 1988-10-21 Impact factor: 56.272