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Literature DB >> 3495806

A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells.

D J FitzGerald, M C Willingham, C O Cardarelli, H Hamada, T Tsuruo, M M Gottesman, I Pastan.

Abstract

One form of multidrug resistance is due to the expression of a 170-kDa energy-dependent drug efflux pump called P-glycoprotein in the plasma membranes of human cancer cells. We have prepared conjugates of Pseudomonas toxin with the anti-P-glycoprotein monoclonal antibody MRK-16. These anti-P-glycoprotein-toxin conjugates specifically kill multidrug-resistant human KB cells. Similar conjugates could be useful in cancer therapy to reduce or eliminate multidrug-resistant tumor populations in tumors intrinsically resistant to chemotherapy or in populations that become resistant during combination chemotherapy.

Entities: Chemical

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Year: 1987 PMID： 3495806 PMCID： PMC305070 DOI： 10.1073/pnas.84.12.4288

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 12.779

25 in total

1. Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

Authors: K Ueda; C Cardarelli; M M Gottesman; I Pastan
Journal: Proc Natl Acad Sci U S A Date: 1987-05 Impact factor: 11.205

2. Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.

Authors: D W Shen; C Cardarelli; J Hwang; M Cornwell; N Richert; S Ishii; I Pastan; M M Gottesman
Journal: J Biol Chem Date: 1986-06-15 Impact factor: 5.157

3. Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies.

Authors: J L Biedler; H Riehm
Journal: Cancer Res Date: 1970-04 Impact factor: 12.701

4. Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts.

Authors: W T Beck; T J Mueller; L R Tanzer
Journal: Cancer Res Date: 1979-06 Impact factor: 12.701

5. Isolation and genetic characterization of human KB cell lines resistant to multiple drugs.

Authors: S Akiyama; A Fojo; J A Hanover; I Pastan; M M Gottesman
Journal: Somat Cell Mol Genet Date: 1985-03

6. Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines.

Authors: N Kartner; J R Riordan; V Ling
Journal: Science Date: 1983-09-23 Impact factor: 47.728

7. Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification.

Authors: D W Shen; A Fojo; J E Chin; I B Roninson; N Richert; I Pastan; M M Gottesman
Journal: Science Date: 1986-05-02 Impact factor: 47.728

8. Increased vinblastine binding to membrane vesicles from multidrug-resistant KB cells.

Authors: M M Cornwell; M M Gottesman; I H Pastan
Journal: J Biol Chem Date: 1986-06-15 Impact factor: 5.157

9. Enhancement of toxicity of antitransferrin receptor antibody-Pseudomonas exotoxin conjugates by adenovirus.

Authors: D J FitzGerald; I S Trowbridge; I Pastan; M C Willingham
Journal: Proc Natl Acad Sci U S A Date: 1983-07 Impact factor: 12.779

10. Pseudomonas exotoxin-anti-TAC. Cell-specific immunotoxin active against cells expressing the human T cell growth factor receptor.

Authors: D J FitzGerald; T A Waldmann; M C Willingham; I Pastan
Journal: J Clin Invest Date: 1984-09 Impact factor: 19.456

29 in total

Review 1. Genetic aspects of multidrug resistance.

Authors: M Pauly; F Ries; M Dicato
Journal: Med Oncol Tumor Pharmacother Date: 1992

Review 2. Drug resistance in oncology: from concepts to applications.

Authors: J L Cazin; P Gosselin; P Cappelaere; J Robert; A Demaille
Journal: J Cancer Res Clin Oncol Date: 1992 Impact factor: 4.553

3. Phototoxic liposomes coupled to an antibody that alone cannot modulate its cell-surface antigen kill selected target cells.

Authors: S Yemul; C Berger; M Katz; A Estabrook; R Edelson; H Bayley
Journal: Cancer Immunol Immunother Date: 1990 Impact factor: 6.968

A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells.

1. Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

2. Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.

3. Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies.

4. Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts.

5. Isolation and genetic characterization of human KB cell lines resistant to multiple drugs.

6. Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines.

7. Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification.

8. Increased vinblastine binding to membrane vesicles from multidrug-resistant KB cells.

9. Enhancement of toxicity of antitransferrin receptor antibody-Pseudomonas exotoxin conjugates by adenovirus.

10. Pseudomonas exotoxin-anti-TAC. Cell-specific immunotoxin active against cells expressing the human T cell growth factor receptor.

Review 1. Genetic aspects of multidrug resistance.

Review 2. Drug resistance in oncology: from concepts to applications.

3. Phototoxic liposomes coupled to an antibody that alone cannot modulate its cell-surface antigen kill selected target cells.

Review 4. Antineoplastic drugs in 1990. A review (Part II).

5. Conformational effects of amino acid substitutions in the P-glycoprotein of the mdr 1 gene.

6. Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

7. Establishment and characterization of a multidrug-resistant human bladder carcinoma cell line RT112/D21.

8. Drug resistance in rat colon cancer cell lines is associated with minor changes in susceptibility to cytotoxic cells.

9. Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody.

Review 10. Antibody-directed therapy of multidrug-resistant tumor cells.