Literature DB >> 34956782

Response to Immunotherapy in Adenocarcinoma Lung With Gastric Metastasis: A Rare Case Report and Review of Literature.

Saroj Kumar Das Majumdar1, Bikash Ranjan Mahapatra1, Anupam Muraleedharan1, Dillip Kumar Parida1, Amit Kumar Adhya2.   

Abstract

Worldwide lung cancer is the most common cause of cancer mortality. Most of the lung cancer patients present with advanced disease at the time of diagnosis, and in that case, the prognosis is poor even with treatment. The most common sites of metastases in non-small-cell lung cancer are the brain, bone, liver, and adrenal gland. Metastasis to the stomach is extremely rare, which carries with itself a more dismal prognosis. Here we are reporting a rare case of adenocarcinoma lung with metastasis to the stomach, which was initially a diagnostic dilemma. The patient survived for 30 months from the diagnosis of gastric metastasis by management predominantly with immunotherapy.
Copyright © 2021, Das Majumdar et al.

Entities:  

Keywords:  gastric metastasis; immunotherapy; lung cancer; pd-l1; pembrolizumab

Year:  2021        PMID: 34956782      PMCID: PMC8693547          DOI: 10.7759/cureus.19790

Source DB:  PubMed          Journal:  Cureus        ISSN: 2168-8184


  16 in total

1.  Gastric metastasis from small cell lung cancer: a case report.

Authors:  Song Gao; Xu-Dong Hu; Su-Zhen Wang; Ning Liu; Wei Zhao; Qing-Xi Yu; Wen-Hong Hou; Shuang-Hu Yuan
Journal:  World J Gastroenterol       Date:  2015-02-07       Impact factor: 5.742

2.  Updated Analysis of KEYNOTE-024: Pembrolizumab Versus Platinum-Based Chemotherapy for Advanced Non-Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score of 50% or Greater.

Authors:  Martin Reck; Delvys Rodríguez-Abreu; Andrew G Robinson; Rina Hui; Tibor Csőszi; Andrea Fülöp; Maya Gottfried; Nir Peled; Ali Tafreshi; Sinead Cuffe; Mary O'Brien; Suman Rao; Katsuyuki Hotta; Kristel Vandormael; Antonio Riccio; Jing Yang; M Catherine Pietanza; Julie R Brahmer
Journal:  J Clin Oncol       Date:  2019-01-08       Impact factor: 44.544

3.  Gastric metastasis by lung small cell carcinoma.

Authors:  Giovanni Casella; Camillo Di Bella; Antonino Roberto Cambareri; Carmelo Antonio Buda; Gianluigi Corti; Filippo Magri; Stefano Crippa; Vittorio Baldini
Journal:  World J Gastroenterol       Date:  2006-07-07       Impact factor: 5.742

4.  Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases.

Authors:  P Chu; E Wu; L M Weiss
Journal:  Mod Pathol       Date:  2000-09       Impact factor: 7.842

5.  Outcomes to first-line pembrolizumab in patients with non-small-cell lung cancer and very high PD-L1 expression.

Authors:  E J Aguilar; B Ricciuti; J F Gainor; K L Kehl; S Kravets; S Dahlberg; M Nishino; L M Sholl; A Adeni; S Subegdjo; S Khosrowjerdi; R M Peterson; S Digumarthy; C Liu; J Sauter; H Rizvi; K C Arbour; B W Carter; J V Heymach; M Altan; M D Hellmann; M M Awad
Journal:  Ann Oncol       Date:  2019-10-01       Impact factor: 32.976

Review 6.  Clinicopathological features and treatment outcomes of metastatic tumors in the stomach.

Authors:  Tsutomu Namikawa; Kazuhiro Hanazaki
Journal:  Surg Today       Date:  2013-07-30       Impact factor: 2.549

7.  Gastrointestinal metastases from malignant tumors of the lung.

Authors:  A S Antler; Y Ough; C S Pitchumoni; M Davidian; W Thelmo
Journal:  Cancer       Date:  1982-01-01       Impact factor: 6.860

8.  Clinical and organizational factors in the initial evaluation of patients with lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines.

Authors:  David E Ost; Sai-Ching Jim Yeung; Lynn T Tanoue; Michael K Gould
Journal:  Chest       Date:  2013-05       Impact factor: 9.410

9.  Primary lung cancer presenting with gastrointestinal tract involvement: clinicopathologic and immunohistochemical features in a series of 18 consecutive cases.

Authors:  Giulio Rossi; Alessandro Marchioni; Elena Romagnani; Federica Bertolini; Lucia Longo; Alberto Cavazza; Fausto Barbieri
Journal:  J Thorac Oncol       Date:  2007-02       Impact factor: 15.609

10.  Metastatic spread in patients with gastric cancer.

Authors:  Matias Riihimäki; Akseli Hemminki; Kristina Sundquist; Jan Sundquist; Kari Hemminki
Journal:  Oncotarget       Date:  2016-08-09
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