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Literature DB >> 3494854

Cell transformation by a virus containing a molecularly constructed gag-erbB fused gene.

S Kawai, M Nishizawa, T Yamamoto, K Toyoshima.

Abstract

A provirus DNA that contains a gag-erbB fused gene as the sole and transforming gene was molecularly constructed from plasmid pSRA2 containing the entire genome of Rous sarcoma virus and pAE7.7 containing the entire genome of an avian erythroblastosis virus (AEV), AEV-H. A virus containing the gag-erbB fused gene (GEV) was recovered from chicken embryo fibroblasts transfected with the proviral DNA and a helper virus DNA. GEV could transform chicken embryo fibroblasts as efficiently as could AEV-H. Anti-erbB and anti-gag sera immunoprecipitated a protein with a molecular weight of about 110,000 from GEV-transformed cells. The erbB and gag-erbB fused-gene products in AEV-H- and GEV-transformed cells were analyzed.

Entities: Gene Species

Mesh：

Substances：

Year: 1987 PMID： 3494854 PMCID： PMC254151 DOI： 10.1128/JVI.61.5.1665-1669.1987

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

19 in total

1. Isolation of different kinds of non-virus producing chick cells transformed by Schmidt-Ruppin strain (subgroup A) of Rous sarcoma virus.

Authors: S Kawai; T Yamamoto
Journal: Jpn J Exp Med Date: 1970-08

2. Identification and characterization of the avian erythroblastosis virus erbB gene product as a membrane glycoprotein.

Authors: M J Hayman; G M Ramsay; K Savin; G Kitchener; T Graf; H Beug
Journal: Cell Date: 1983-02 Impact factor: 41.582

3. The erbB gene of avian erythroblastosis virus is a member of the src gene family.

Authors: T Yamamoto; T Nishida; N Miyajima; S Kawai; T Ooi; K Toyoshima
Journal: Cell Date: 1983-11 Impact factor: 41.582

Review 4. Role of the v-erbA and v-erbB oncogenes of avian erythroblastosis virus in erythroid cell transformation.

Authors: T Graf; H Beug
Journal: Cell Date: 1983-08 Impact factor: 41.582

5. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences.

Authors: J Downward; Y Yarden; E Mayes; G Scrace; N Totty; P Stockwell; A Ullrich; J Schlessinger; M D Waterfield
Journal: Nature Date: 1984 Feb 9-15 Impact factor: 49.962

6. Temperature-sensitive mutants of avian erythroblastosis virus: surface expression of the erbB product correlates with transformation.

Authors: H Beug; M J Hayman
Journal: Cell Date: 1984-04 Impact factor: 41.582

7. Antisera from mice and rats incubated with syngeneic Rous sarcoma cells.

Authors: S Kawai; K Segawa; T Yamamoto
Journal: Jpn J Exp Med Date: 1980-10

8. Embryonic erythroid cells transformed by avian erythroblastosis virus may proliferate and differentiate.

Authors: P Jurdic; M Bouabdelli; M G Moscovici; C Moscovici
Journal: Virology Date: 1985-07-15 Impact factor: 3.616

9. The product of the avian erythroblastosis virus erbB locus is a glycoprotein.

Authors: M L Privalsky; L Sealy; J M Bishop; J P McGrath; A D Levinson
Journal: Cell Date: 1983-04 Impact factor: 41.582

10. A new avian erythroblastosis virus, AEV-H, carries erbB gene responsible for the induction of both erythroblastosis and sarcomas.

Authors: T Yamamoto; H Hihara; T Nishida; S Kawai; K Toyoshima
Journal: Cell Date: 1983-08 Impact factor: 41.582

4 in total

4. Truncation of the human EGF receptor leads to differential transforming potentials in primary avian fibroblasts and erythroblasts.

Authors: K Khazaie; T J Dull; T Graf; J Schlessinger; A Ullrich; H Beug; B Vennström
Journal: EMBO J Date: 1988-10 Impact factor: 11.598