Literature DB >> 6323030

Temperature-sensitive mutants of avian erythroblastosis virus: surface expression of the erbB product correlates with transformation.

H Beug, M J Hayman.   

Abstract

The v-erbB gene of avian erythroblastosis virus (AEV) codes for an integral plasma membrane glycoprotein, gp74erbB. Expression of gp74erbB and its intracellular precursors, gp66erbB and gp68erbB, has been studied in cells transformed by two temperature-sensitive mutants of AEV. After shift to 42 degrees C, the processing of gp68erbB is blocked in tsAEV-transformed, but not in wtAEV-transformed, erythroblasts and fibroblasts. In addition, gp74erbB disappears from the surface of tsAEV cells within 12 hr after shift. Thus tsAEV mutants probably bear a lesion in v-erbB that affects the maturation and subcellular localization of gp74erbB. The tsAEV erythroblasts, when "committed" to differentiation by a pulse-shift to 42 degrees C, reexpress gp74erbB during terminal differentiation at 36 degrees C. This suggests that tsAEV erythroblasts become insensitive to the transforming functions of gp74erbB at a certain stage of differentiation.

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Year:  1984        PMID： 6323030     DOI： 10.1016/0092-8674(84)90046-1

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  28 in total

1.  Dissecting the activating mutations in v-erbB of avian erythroblastosis virus strain R.

Authors:  H K Shu; R J Pelley; H J Kung
Journal:  J Virol       Date:  1991-11       Impact factor: 5.103

2.  The amino-terminal 14 amino acids of v-src can functionally replace the extracellular and transmembrane domains of v-erbB.

Authors:  M McMahon; R C Schatzman; J M Bishop
Journal:  Mol Cell Biol       Date:  1991-09       Impact factor: 4.272

3.  Two point mutations in the transmembrane domain of P68gag-ros inactive its transforming activity and cause a delay in membrane association.

Authors:  S M Jong; L H Wang
Journal:  J Virol       Date:  1991-01       Impact factor: 5.103

4.  Ligand-independent dimerization of oncogenic v-erbB products involves covalent interactions.

Authors:  M A Adelsman; B K Huntley; N J Maihle
Journal:  J Virol       Date:  1996-04       Impact factor: 5.103

5.  The putative transforming protein of S13 avian erythroblastosis virus is a transmembrane glycoprotein with an associated protein kinase activity.

Authors:  M J Hayman; G Kitchener; P K Vogt; H Beug
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

6.  Proviral insertional activation of c-erbB: differential processing of the protein products arising from two alternate transcripts.

Authors:  N J Maihle; M A Raines; T W Flickinger; H J Kung
Journal:  Mol Cell Biol       Date:  1988-11       Impact factor: 4.272

7.  Orientation of the v-erb-B gene product in the plasma membrane.

Authors:  R C Schatzman; G I Evan; M L Privalsky; J M Bishop
Journal:  Mol Cell Biol       Date:  1986-04       Impact factor: 4.272

8.  AEV-transformed erythroleukemia cell induced differentiation: expression of specific cell membrane antigenic molecules.

Authors:  I Raynaud; J M Biquard; P Chambard; B Fasciotto; J Samarut; J P Blanchet; V Krsmanovic
Journal:  Arch Virol       Date:  1987       Impact factor: 2.574

9.  raf/myc-infected erythroid cells are restricted in their ability to terminally differentiate.

Authors:  S P Klinken; U R Rapp; H C Morse
Journal:  J Virol       Date:  1989-03       Impact factor: 5.103

10.  Creation of a chimeric oncogene: analysis of the biochemical and biological properties of v-erbB/src fusion polypeptide.

Authors:  M L Privalsky
Journal:  J Virol       Date:  1987-06       Impact factor: 5.103
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