Literature DB >> 3494425

Effect of minimal amounts of thymidine on activity of trimethoprim-sulfamethoxazole against Staphylococcus epidermidis.

C Jones, D L Stevens, O Ojo.   

Abstract

The antibacterial activity of trimethoprim-sulfamethoxazole against 99 strains of Staphylococcus epidermidis was tested on media known to be low in thymidine content, as determined by screening with Streptococcus faecalis. Eighty-one percent of the isolates were susceptible by agar dilution. Trimethoprim-sulfamethoxazole was bactericidal against two strains of S. epidermidis when thymidine phosphorylase was added to the medium, indicating utilization of minimal amounts of thymidine that were undetected by screening. Because bacteria vary in their utilization of thymidine and body tissues vary in thymidine content, in vitro susceptibility tests may not correlate with in vivo bactericidal activity.

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Year:  1987        PMID： 3494425      PMCID： PMC174679          DOI： 10.1128/AAC.31.2.144

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Identification of Harper-Cawston factor as thymidine phosphorylase and removal from media of substances interfering with susceptibility testing to sulfonamides and diaminopyrimidines.

Authors:  R Ferone; S R Bushby; J J Burchall; W D Moore; D Smith
Journal:  Antimicrob Agents Chemother       Date:  1975-01       Impact factor: 5.191

2.  Simplified scheme for routine identification of human Staphylococcus species.

Authors:  W E Kloos; K H Schleifer
Journal:  J Clin Microbiol       Date:  1975-01       Impact factor: 5.948

3.  The biochemical basis of the antimicrobial action of sulfonamides and trimethoprim in vivo--I. Action of sulfonamides and trimethoprim in blood and urine.

Authors:  R Then; P Angehrn
Journal:  Biochem Pharmacol       Date:  1974-11-01       Impact factor: 5.858

4.  Thymidine concentrations in serum and urine of different animal species and man.

Authors:  H Nottebrock; R Then
Journal:  Biochem Pharmacol       Date:  1977-11-15       Impact factor: 5.858

5.  Reversal of the antimicrobial activity of trimethoprim by thymidine in commercially prepared media.

Authors:  A E Koch; J J Burchall
Journal:  Appl Microbiol       Date:  1971-11

Review 6.  Trimethoprim-sulfamethoxazole for bacterial meningitis.

Authors:  R E Levitz; R Quintiliani
Journal:  Ann Intern Med       Date:  1984-06       Impact factor: 25.391

7.  Method of reliable determination of minimal lethal antibiotic concentrations.

Authors:  R D Pearson; R T Steigbigel; H T Davis; S W Chapman
Journal:  Antimicrob Agents Chemother       Date:  1980-11       Impact factor: 5.191

8.  Exogenous thymidine and reversal of the inhibitory effect of sulfamethoxazole-trimethoprim on streptococci.

Authors:  P F Coll; V R Ausina; J V Vernis; B O Mirelis; G P Prats
Journal:  Eur J Clin Microbiol       Date:  1984-10       Impact factor: 3.267

Review 9.  Significance of the sulfonamide component for the clinical efficacy of trimethoprim-sulfonamide combinations.

Authors:  L G Burman
Journal:  Scand J Infect Dis       Date:  1986

10.  Susceptibility of enterococci to trimethoprim and trimethoprim-sulfamethoxazole.

Authors:  S R Crider; S D Colby
Journal:  Antimicrob Agents Chemother       Date:  1985-01       Impact factor: 5.191
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  6 in total

1.  Efficacy of iclaprim against wild-type and thymidine kinase-deficient methicillin-resistant Staphylococcus aureus isolates in an in vitro fibrin clot model.

Authors:  José M Entenza; Andreas Haldimann; Marlyse Giddey; Sergio Lociuro; Stephen Hawser; Philippe Moreillon
Journal:  Antimicrob Agents Chemother       Date:  2009-06-29       Impact factor: 5.191

2.  Synergistic antimicrobial activities of folic acid antagonists and nucleoside analogs.

Authors:  Johannes Zander; Silke Besier; Hanns Ackermann; Thomas A Wichelhaus
Journal:  Antimicrob Agents Chemother       Date:  2009-12-22       Impact factor: 5.191

3.  Killing of nongrowing and adherent Escherichia coli determines drug efficacy in device-related infections.

Authors:  A F Widmer; A Wiestner; R Frei; W Zimmerli
Journal:  Antimicrob Agents Chemother       Date:  1991-04       Impact factor: 5.191

4.  Efficacy evaluation of iclaprim in a neutropenic rat lung infection model with methicillin-resistant Staphylococcus aureus entrapped in alginate microspheres.

Authors:  David B Huang; Ian Morrissey; Timothy Murphy; Stephen Hawser; Mark H Wilcox
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2017-12-08       Impact factor: 3.267

5.  In Vitro Time-Kill Studies of Trimethoprim/Sulfamethoxazole against Stenotrophomonas maltophilia versus Escherichia coli Using Cation-Adjusted Mueller-Hinton Broth and ISO-Sensitest Broth.

Authors:  Maxwell J Lasko; Matthew L Gethers; Jennifer L Tabor-Rennie; David P Nicolau; Joseph L Kuti
Journal:  Antimicrob Agents Chemother       Date:  2022-01-10       Impact factor: 5.938

6.  RexAB is essential for the mutagenic repair of Staphylococcus aureus DNA damage caused by co-trimoxazole.

Authors:  Rebecca S Clarke; Maya S Bruderer; Kam Pou Ha; Andrew M Edwards
Journal:  Antimicrob Agents Chemother       Date:  2019-10-07       Impact factor: 5.191
  6 in total

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