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Literature DB >> 3493812

Optical recording of action potential propagation in demyelinated frog nerve.

P Shrager, S Y Chiu, J M Ritchie, D Zecevic, L B Cohen.

Abstract

Conduction in focally demyelinated frog nerves has been measured optically using potential-sensitive dyes. Absorption changes were recorded with an array of photodiodes positioned in the image plane of a microscope. Both the amplitude and conduction velocity of the optical signals decreased in the demyelinated region. Conduction was improved after exposure to the potassium channel blocking agent 4-aminopyridine.

Entities: Chemical

Mesh：

Year: 1987 PMID： 3493812 PMCID： PMC1329897 DOI： 10.1016/S0006-3495(87)83342-8

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

14 in total

1. Ca2+- and K+-dependent communication between central nervous system myelinated axons and oligodendrocytes revealed by voltage-sensitive dyes.

Authors: V Lev-Ram; A Grinvald
Journal: Proc Natl Acad Sci U S A Date: 1986-09 Impact factor: 11.205

2. Density of sodium channels in mammalian myelinated nerve fibers and nature of the axonal membrane under the myelin sheath.

Authors: J M Ritchie; R B Rogart
Journal: Proc Natl Acad Sci U S A Date: 1977-01 Impact factor: 11.205

3. [The effect of tetraethylammonium chloride on single Ranvier's nodes].

Authors: H Schmidt; R Stämpfli
Journal: Pflugers Arch Gesamte Physiol Menschen Tiere Date: 1966

4. Evidence for the presence of potassium channels in the internode of frog myelinated nerve fibres.

Authors: S Y Chiu; J M Ritchie
Journal: J Physiol Date: 1982-01 Impact factor: 5.182

5. Simultaneous optical monitoring of activity of many neurons in invertebrate ganglia using a 124-element photodiode array.

Authors: A Grinvald; L B Cohen; S Lesher; M B Boyle
Journal: J Neurophysiol Date: 1981-05 Impact factor: 2.714

9. Evidence for the presence of potassium channels in the paranodal region of acutely demyelinated mammalian single nerve fibres.

Authors: S Y Chiu; J M Ritchie
Journal: J Physiol Date: 1981 Impact factor: 5.182

Optical recording of action potential propagation in demyelinated frog nerve.

1. Ca2+- and K+-dependent communication between central nervous system myelinated axons and oligodendrocytes revealed by voltage-sensitive dyes.

2. Density of sodium channels in mammalian myelinated nerve fibers and nature of the axonal membrane under the myelin sheath.

3. [The effect of tetraethylammonium chloride on single Ranvier's nodes].

4. Evidence for the presence of potassium channels in the internode of frog myelinated nerve fibres.

5. Simultaneous optical monitoring of activity of many neurons in invertebrate ganglia using a 124-element photodiode array.

6. Interactions of aminopyridines with potassium channels of squid axon membranes.

7. The internodal axon membrane: electrical excitability and continuous conduction in segmental demyelination.

8. The effects of 4-aminopyridine and tetraethylammonium ions on normal and demyelinated mammalian nerve fibres.

9. Evidence for the presence of potassium channels in the paranodal region of acutely demyelinated mammalian single nerve fibres.

10. The permeability of the sodium channel to organic cations in myelinated nerve.

1. Conduction in segmentally demyelinated mammalian central axons.

2. Fast optical monitoring of microscopic excitation patterns in cardiac muscle.

3. Optical measurement of conduction in single demyelinated axons.