Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Sequence of the cDNA encoding the laminin B1 chain reveals a multidomain protein containing cysteine-rich repeats.

Literature DB >> 3493487

Sequence of the cDNA encoding the laminin B1 chain reveals a multidomain protein containing cysteine-rich repeats.

M Sasaki, S Kato, K Kohno, G R Martin, Y Yamada.

Abstract

Laminin is a basement membrane-specific glycoprotein (800 kDa) consisting of three chains: A, B1, and B2. Laminin has diverse biological functions, which include stimulating epithelial cell growth and differentiation. We have isolated two overlapping cDNA clones that span 5.9 kilobases and code for the entire B1 chain of mouse laminin. The nucleotide sequence of the clones reveals a 5358-base pair open reading frame that potentially codes for 1786 amino acids, including 20 amino acids of a presumptive signal peptide. Analysis of the deduced protein sequence predicts that the B1 chain has seven distinct domains that include cysteine-rich repeats, alpha-helical, and globular structures. Part of the cysteine-rich region is homologous to epidermal growth factor and other proteins that contain epidermal growth factor-like repeats.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1987 PMID： 3493487 PMCID： PMC304334 DOI： 10.1073/pnas.84.4.935

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

36 in total

1. Laminin--a glycoprotein from basement membranes.

Authors: R Timpl; H Rohde; P G Robey; S I Rennard; J M Foidart; G R Martin
Journal: J Biol Chem Date: 1979-10-10 Impact factor: 5.157

2. Los Alamos sequence analysis package for nucleic acids and proteins.

Authors: M I Kanehisa
Journal: Nucleic Acids Res Date: 1982-01-11 Impact factor: 16.971

3. Shapes, domain organizations and flexibility of laminin and fibronectin, two multifunctional proteins of the extracellular matrix.

Authors: J Engel; E Odermatt; A Engel; J A Madri; H Furthmayr; H Rohde; R Timpl
Journal: J Mol Biol Date: 1981-07-25 Impact factor: 5.469

4. Protease resistance and conformation of laminin.

Authors: U Ott; E Odermatt; J Engel; H Furthmayr; R Timpl
Journal: Eur J Biochem Date: 1982-03

5. An interactive graphics program for comparing and aligning nucleic acid and amino acid sequences.

Authors: R Staden
Journal: Nucleic Acids Res Date: 1982-05-11 Impact factor: 16.971

6. Isolation of a subunit of laminin and its role in molecular structure and tumor cell attachment.

Authors: C N Rao; I M Margulies; T S Tralka; V P Terranova; J A Madri; L A Liotta
Journal: J Biol Chem Date: 1982-08-25 Impact factor: 5.157

7. Sequence organization of two recombinant plasmids containing genes for the major heat shock-induced protein of D. melanogaster.

Authors: E A Craig; B J McCarthy; S C Wadsworth
Journal: Cell Date: 1979-03 Impact factor: 41.582

8. Hormonal induction of differentiation in teratocarcinoma stem cells: generation of parietal endoderm by retinoic acid and dibutyryl cAMP.

Authors: S Strickland; K K Smith; K R Marotti
Journal: Cell Date: 1980-09 Impact factor: 41.582

9. Localization of binding sites for laminin, heparan sulfate proteoglycan and fibronectin on basement membrane (type IV) collagen.

Authors: G W Laurie; J T Bing; H K Kleinman; J R Hassell; M Aumailley; G R Martin; R J Feldmann
Journal: J Mol Biol Date: 1986-05-05 Impact factor: 5.469

10. A murine tumor producing a matrix of basement membrane.

Authors: R W Orkin; P Gehron; E B McGoodwin; G R Martin; T Valentine; R Swarm
Journal: J Exp Med Date: 1977-01-01 Impact factor: 14.307

88 in total

1. Molecular basis of loss-of-function mutations in the glp-1 gene of Caenorhabditis elegans.

Authors: V Kodoyianni; E M Maine; J Kimble
Journal: Mol Biol Cell Date: 1992-11 Impact factor: 4.138

2. Distribution and isolation of four laminin variants; tissue restricted distribution of heterotrimers assembled from five different subunits.

Authors: E Engvall; D Earwicker; T Haaparanta; E Ruoslahti; J R Sanes
Journal: Cell Regul Date: 1990-09

3. Laminin-mediated adhesion in metastatic rat rhabdomyosarcoma cell lines involves prominent interactions with the laminin E8 fragment.

Authors: J C Lissitzky; M Bouzon; E Loret; M F Poupon; P M Martin
Journal: Clin Exp Metastasis Date: 1989 Jul-Aug Impact factor: 5.150

4. Evaluation of mRNA steady-state and protein levels for basement membrane proteins in cultured murine cells.

Authors: I Oberbäumer; C Speth
Journal: Cell Tissue Res Date: 1992-06 Impact factor: 5.249

5. Structure of the human hexabrachion (tenascin) gene.

Authors: J R Gulcher; D E Nies; M J Alexakos; N A Ravikant; M E Sturgill; L S Marton; K Stefansson
Journal: Proc Natl Acad Sci U S A Date: 1991-11-01 Impact factor: 11.205

6. Differential expression of mRNAs encoding laminin chain variants during in vitro development of mouse blastocysts.

Authors: M Azimi; T Niimi; N Yoshida; Y Kitagawa
Journal: Cytotechnology Date: 1999-09 Impact factor: 2.058

7. A retinoic acid-responsive element is present in the 5' flanking region of the laminin B1 gene.

Authors: G W Vasios; J D Gold; M Petkovich; P Chambon; L J Gudas
Journal: Proc Natl Acad Sci U S A Date: 1989-12 Impact factor: 11.205

8. Structural analysis of the uEGF gene in the sea urchin strongylocentrotus purpuratus reveals more similarity to vertebrate than to invertebrate genes with EGF-like repeats.

Authors: M G Delgadillo-Reynoso; D R Rollo; D A Hursh; R A Raff
Journal: J Mol Evol Date: 1989-10 Impact factor: 2.395

9. The cysteine-rich protein gene family of Giardia lamblia: loss of the CRP170 gene in an antigenic variant.

Authors: R D Adam; Y M Yang; T E Nash
Journal: Mol Cell Biol Date: 1992-03 Impact factor: 4.272

10. Adhesion polypeptides are useful for the prevention of peritoneal dissemination of gastric cancer.

Authors: T Matsuoka; K Hirakawa; Y S Chung; M Yashiro; S Nishimura; T Sawada; I Saiki; M Sowa
Journal: Clin Exp Metastasis Date: 1998-05 Impact factor: 5.150