Henry T Shu1, Jacob D Mikula1, Andrew T Yu2, Babar Shafiq1. 1. Department of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, MD, USA. 2. Department of Neurology, The Johns Hopkins University, Baltimore, MD, USA.
Abstract
PURPOSE: The purpose of this study is to determine whether tranexamic acid (TXA) use was associated with lower rates of blood transfusion in patients undergoing pelvic and/or acetabular fracture surgery. METHODS: Four studies were included, 3 of which were included in the pooled data analysis for a total of 308 patients. RESULTS: The transfusion rate was significantly lower in the TXA group (44%) compared with the non-TXA group (57%) (P = 0.02). CONCLUSION: TXA use was associated with a significantly lower transfusion rate in patients who underwent pelvic and/or acetabular fracture surgery. LEVEL OF EVIDENCE: Level 3. Systematic review of retrospective cohort studies and prospective randomized controlled trials.
PURPOSE: The purpose of this study is to determine whether tranexamic acid (TXA) use was associated with lower rates of blood transfusion in patients undergoing pelvic and/or acetabular fracture surgery. METHODS: Four studies were included, 3 of which were included in the pooled data analysis for a total of 308 patients. RESULTS: The transfusion rate was significantly lower in the TXA group (44%) compared with the non-TXA group (57%) (P = 0.02). CONCLUSION: TXA use was associated with a significantly lower transfusion rate in patients who underwent pelvic and/or acetabular fracture surgery. LEVEL OF EVIDENCE: Level 3. Systematic review of retrospective cohort studies and prospective randomized controlled trials.
Authors: Wayne B Cohen-Levy; Augustus J Rush; Joshua P Goldstein; Jonathan I Sheu; Roberto C Hernandez-Irizarry; Stephen M Quinnan Journal: Int Orthop Date: 2020-05-09 Impact factor: 3.075
Authors: Heather A Vallier; Timothy A Moore; John J Como; Patricia A Wilczewski; Michael P Steinmetz; Karl G Wagner; Charles E Smith; Xiao-Feng Wang; Andrea J Dolenc Journal: J Orthop Surg Res Date: 2015-10-01 Impact factor: 2.359