Literature DB >> 34918300

Humanized Patient-Derived Xenograft Models of Ovarian Cancer.

Sarah B Gitto1,2, Erin George3, Sergey Medvedev3, Fiona Simpkins3, Daniel J Powell4,5.   

Abstract

In vivo modeling of cancer is a critical step in testing novel therapeutic strategies to advance patient care. Here we describe how to develop a humanized patient-derived xenograft (PDX) model of ovarian cancer that uses orthotopically transplanted patient ovarian tumors with autologous transfer of expanded tumor infiltrating T cells (TILs) as a model that can be utilized to test immunomodulating therapeutics in vivo.
© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Immune checkpoint blockade; Immunotherapy; In vivo modeling; Patient-derived xenograft; T-cell expansion; Tumor infiltrating lymphocytes

Mesh：

Year:  2022        PMID： 34918300     DOI： 10.1007/978-1-0716-1956-8_17

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  18 in total

Review 1.  Tumor Microenvironment and Differential Responses to Therapy.

Authors:  Eishu Hirata; Erik Sahai
Journal:  Cold Spring Harb Perspect Med       Date:  2017-07-05       Impact factor: 6.915

Review 2.  Lost in translation: animal models and clinical trials in cancer treatment.

Authors:  Isabella Wy Mak; Nathan Evaniew; Michelle Ghert
Journal:  Am J Transl Res       Date:  2014-01-15       Impact factor: 4.060

3.  A patient-derived-xenograft platform to study BRCA-deficient ovarian cancers.

Authors:  Erin George; Hyoung Kim; Clemens Krepler; Brandon Wenz; Mehran Makvandi; Janos L Tanyi; Eric Brown; Rugang Zhang; Patricia Brafford; Stephanie Jean; Robert H Mach; Yiling Lu; Gordon B Mills; Meenhard Herlyn; Mark Morgan; Xiaochen Zhang; Robert Soslow; Ronny Drapkin; Neil Johnson; Ying Zheng; George Cotsarelis; Katherine L Nathanson; Fiona Simpkins
Journal:  JCI Insight       Date:  2017-01-12

4.  Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics.

Authors:  Joyce F Liu; Sangeetha Palakurthi; Qing Zeng; Shan Zhou; Elena Ivanova; Wei Huang; Ioannis K Zervantonakis; Laura M Selfors; Yiping Shen; Colin C Pritchard; Mei Zheng; Vilmos Adleff; Eniko Papp; Huiying Piao; Marian Novak; Susan Fotheringham; Gerburg M Wulf; Jessie English; Paul T Kirschmeier; Victor E Velculescu; Cloud Paweletz; Gordon B Mills; David M Livingston; Joan S Brugge; Ursula A Matulonis; Ronny Drapkin
Journal:  Clin Cancer Res       Date:  2016-08-29       Impact factor: 12.531

Review 5.  Of mice and not men: differences between mouse and human immunology.

Authors:  Javier Mestas; Christopher C W Hughes
Journal:  J Immunol       Date:  2004-03-01       Impact factor: 5.422

6.  The tumor microenvironment.

Authors:  Nicole M Anderson; M Celeste Simon
Journal:  Curr Biol       Date:  2020-08-17       Impact factor: 10.834

7.  Evaluating cell lines as tumour models by comparison of genomic profiles.

Authors:  Silvia Domcke; Rileen Sinha; Douglas A Levine; Chris Sander; Nikolaus Schultz
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

Review 8.  Current status and perspectives of patient-derived xenograft models in cancer research.

Authors:  Yunxin Lai; Xinru Wei; Shouheng Lin; Le Qin; Lin Cheng; Peng Li
Journal:  J Hematol Oncol       Date:  2017-05-12       Impact factor: 17.388

9.  Patient-derived xenografts faithfully replicated clinical outcome in a phase II co-clinical trial of arsenic trioxide in relapsed small cell lung cancer.

Authors:  Taofeek K Owonikoko; Guojing Zhang; Hyun S Kim; Renea M Stinson; Rabih Bechara; Chao Zhang; Zhengjia Chen; Nabil F Saba; Suchita Pakkala; Rathi Pillai; Xingming Deng; Shi-Yong Sun; Michael R Rossi; Gabriel L Sica; Suresh S Ramalingam; Fadlo R Khuri
Journal:  J Transl Med       Date:  2016-05-03       Impact factor: 5.531

10.  Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment.

Authors:  Eleni Maniati; Chiara Berlato; Ganga Gopinathan; Owen Heath; Panoraia Kotantaki; Anissa Lakhani; Jacqueline McDermott; Colin Pegrum; Robin M Delaine-Smith; Oliver M T Pearce; Priyanka Hirani; Joash D Joy; Ludmila Szabova; Ruth Perets; Owen J Sansom; Ronny Drapkin; Peter Bailey; Frances R Balkwill
Journal:  Cell Rep       Date:  2020-01-14       Impact factor: 9.423
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