| Literature DB >> 34914055 |
Natasha Rodrigues de Oliveira1, Thaís Larré Oliveira1, Sérgio Jorge2, Odir Antônio Dellagostin3.
Abstract
Leptospirosis is a bacterial zoonotic disease with significant impact on health all over the world. Currently, bacterins are the only vaccines available for prevention of this disease, despite several drawbacks. In an effort to develop a more effective vaccine against leptospirosis, reverse and structural vaccinology have been applied to design recombinant constructions composed of leptospiral surface-exposed antigens. Herein, we describe a protocol for design and development of Leptospirosis recombinant vaccines using immunoinformatic approaches.Entities:
Keywords: Experimental infection; Leptospira; Recombinant protein; Structural modeling
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Year: 2022 PMID： 34914055 DOI： 10.1007/978-1-0716-1884-4_16
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745