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Literature DB >> 3491366

Identification of the protein encoded by the human diffuse B-cell lymphoma (dbl) oncogene.

S K Srivastava, R H Wheelock, S A Aaronson, A Eva.

Abstract

The dbl oncogene was initially isolated from a human diffuse B-cell lymphoma. Antisera from mice bearing tumors induced by this oncogene specifically detected a protein of about 66 kDa (p66) in dbl transformants. dbl cDNA-selected poly(A)+ RNA isolated from a transfectant clone expressing p66 directed the in vitro synthesis of this protein, establishing that it is encoded by dbl. Subcellular localization studies revealed that p66 is a cytoplasmic protein distributed between cytosol and crude membrane fractions. Moreover, p66 was shown to be a phosphoprotein, with phosphorylation specific to serine residues. Our characterization of the dbl-encoded protein appears to distinguish this transforming gene product from those of other known oncogenes.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 1986 PMID： 3491366 PMCID： PMC387034 DOI： 10.1073/pnas.83.23.8868

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

37 in total

1. Levels of translatable mRNAs for cell surface protein, collagen precursors, and two membrane proteins are altered in Rous sarcoma virus-transformed chick embryo fibroblasts.

Authors: S L Adams; M E Sobel; B H Howard; K Olden; K M Yamada; B de Crombrugghe; I Pastan
Journal: Proc Natl Acad Sci U S A Date: 1977-08 Impact factor: 11.205

2. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors: H Towbin; T Staehelin; J Gordon
Journal: Proc Natl Acad Sci U S A Date: 1979-09 Impact factor: 11.205

3. Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

Authors: P S Thomas
Journal: Proc Natl Acad Sci U S A Date: 1980-09 Impact factor: 11.205

4. Detection of a transforming gene product in cells transformed by Moloney murine sarcoma virus.

Authors: J Papkoff; I M Verma; T Hunter
Journal: Cell Date: 1982-06 Impact factor: 41.582

5. Molecular cloning and nucleotide sequence of a transforming gene detected by transfection of chicken B-cell lymphoma DNA.

Authors: G Goubin; D S Goldman; J Luce; P E Neiman; G M Cooper
Journal: Nature Date: 1983-03-10 Impact factor: 49.962

6. Transforming gene product of Rous sarcoma virus phosphorylates tyrosine.

Authors: T Hunter; B M Sefton
Journal: Proc Natl Acad Sci U S A Date: 1980-03 Impact factor: 11.205

7. Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.

Authors: H Aviv; P Leder
Journal: Proc Natl Acad Sci U S A Date: 1972-06 Impact factor: 11.205

8. Nucleotide sequence and formation of the transforming gene of a mouse sarcoma virus.

Authors: C Van Beveren; J A Galleshaw; V Jonas; A J Berns; R F Doolittle; D J Donoghue; I M Verma
Journal: Nature Date: 1981-01-22 Impact factor: 49.962

9. Monoclonal antibodies against simian virus 40 T antigens: evidence for distinct sublcasses of large T antigen and for similarities among nonviral T antigens.

Authors: E G Gurney; R O Harrison; J Fenno
Journal: J Virol Date: 1980-06 Impact factor: 5.103

9. Molecular cloning and characterization of the human dbl proto-oncogene: evidence that its overexpression is sufficient to transform NIH/3T3 cells.

Authors: D Ron; S R Tronick; S A Aaronson; A Eva
Journal: EMBO J Date: 1988-08 Impact factor: 11.598

Review 10. Rho GTPases, their post-translational modifications, disease-associated mutations and pharmacological inhibitors.

Authors: Michael F Olson
Journal: Small GTPases Date: 2016-08-22

10 in total

Identification of the protein encoded by the human diffuse B-cell lymphoma (dbl) oncogene.

1. Levels of translatable mRNAs for cell surface protein, collagen precursors, and two membrane proteins are altered in Rous sarcoma virus-transformed chick embryo fibroblasts.

2. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

3. Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

4. Detection of a transforming gene product in cells transformed by Moloney murine sarcoma virus.

5. Molecular cloning and nucleotide sequence of a transforming gene detected by transfection of chicken B-cell lymphoma DNA.

6. Transforming gene product of Rous sarcoma virus phosphorylates tyrosine.

7. Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.

8. Nucleotide sequence and formation of the transforming gene of a mouse sarcoma virus.

9. Monoclonal antibodies against simian virus 40 T antigens: evidence for distinct sublcasses of large T antigen and for similarities among nonviral T antigens.

10. p185, a product of the neu proto-oncogene, is a receptorlike protein associated with tyrosine kinase activity.

1. A minimal Rac activation domain in the unconventional guanine nucleotide exchange factor Dock180.

2. The predicted DBL oncogene product defines a distinct class of transforming proteins.

3. A RHO GTPase-mediated pathway is required during P cell migration in Caenorhabditis elegans.

Review 4. StarD13: a potential star target for tumor therapeutics.

Review 5. Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

Review 6. Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity.

7. Tyrosine phosphorylation of Dbl regulates GTPase signaling.

8. Plekhg4 is a novel Dbl family guanine nucleotide exchange factor protein for rho family GTPases.

9. Molecular cloning and characterization of the human dbl proto-oncogene: evidence that its overexpression is sufficient to transform NIH/3T3 cells.

Review 10. Rho GTPases, their post-translational modifications, disease-associated mutations and pharmacological inhibitors.