Literature DB >> 3490979

The preparation of 11C-labelled fluoromethane for the study of regional cerebral blood flow using positron emission tomography.

S Stone-Elander, P Roland, L Eriksson, J E Litton, P Johnström, L Widén.   

Abstract

Fluoromethane, previously labelled with 18F and used as a tracer in the measurement of regional cerebral blood flow, was 11C-labelled by the reaction of 11C-methyl iodide with tetraethylammonium fluoride. Sufficient quantities of radiotracer were prepared with a minimum amount of handling from 15 min target irradiations in the 14N(p, alpha)11C reaction. Total synthesis time was 25 min from end-of-bombardment, allowing serial blood flow measurements 30 min apart. The use of 11C-fluoromethane as a cerebral blood flow tracer in positron emission tomography is discussed.

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Year:  1986        PMID： 3490979     DOI： 10.1007/BF00251976

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  15 in total

1.  The theory and applications of the exchange of inert gas at the lungs and tissues.

Authors:  S S KETY
Journal:  Pharmacol Rev       Date:  1951-03       Impact factor: 25.468

2.  The determination of regional cerebral blood flow by means of water labeled with radioactive oxygen 15.

Authors:  M M Ter-Pogossian; J O Eichling; D O Davis; M J Welch; J M Metzger
Journal:  Radiology       Date:  1969-07       Impact factor: 11.105

3.  Performance comparison of parameter estimation techniques for the quantitation of local cerebral blood flow by dynamic positron computed tomography.

Authors:  R A Koeppe; J E Holden; W R Ip
Journal:  J Cereb Blood Flow Metab       Date:  1985-06       Impact factor: 6.200

4.  Blood-brain barrier permeability of 11C-labeled alcohols and 15O-labeled water.

Authors:  M E Raichle; J O Eichling; M G Straatmann; M J Welch; K B Larson; M M Ter-Pogossian
Journal:  Am J Physiol       Date:  1976-02

5.  Performance study of the PC-384 positron camera system for emission tomography of the brain.

Authors:  J Litton; M Bergström; L Eriksson; C Bohm; G Blomqvist; M Kesselberg
Journal:  J Comput Assist Tomogr       Date:  1984-02       Impact factor: 1.826

6.  Cerebral blood flow using PET measurements of fluoromethane kinetics.

Authors:  J E Holden; S J Gatley; R D Hichwa; W R Ip; W J Shaughnessy; R J Nickles; R E Polcyn
Journal:  J Nucl Med       Date:  1981-12       Impact factor: 10.057

7.  Normal average value of cerebral blood flow in younger adults is 50 ml/100 g/min.

Authors:  N A Lassen
Journal:  J Cereb Blood Flow Metab       Date:  1985-09       Impact factor: 6.200

8.  18F-labeled lower fluoroalkanes; reactor-produced gaseous physiological tracers.

Authors:  S J Gatley; R D Hichwa; W J Shaughnessy; R J Nickles
Journal:  Int J Appl Radiat Isot       Date:  1981-04

9.  11C-labeled 4-isopropylantipyrine: preparation and biological evaluation as a blood flow tracer in positron emission tomography (PET).

Authors:  S Stone-Elander; M Ingvar; P Johnström; E Ehrin; B Garmelius; T Greitz; J L Nilsson; B Resul; M L Smith; L Widén
Journal:  J Med Chem       Date:  1985-09       Impact factor: 7.446

10.  Dynamic positron emission tomography for study of cerebral hemodynamics in a cross section of the head using positron-emitting 68Ga-EDTA and 77Kr.

Authors:  Y L Yamamoto; C J Thompson; E Meyer; J S Robertson; W Feindel
Journal:  J Comput Assist Tomogr       Date:  1977-01       Impact factor: 1.826
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