| Literature DB >> 34908135 |
Hannah F Löchel1, Marius Welzel1, Georges Hattab1, Anne-Christin Hauschild1, Dominik Heider1.
Abstract
The use of complex biological molecules to solve computational problems is an emerging field at the interface between biology and computer science. There are two main categories in which biological molecules, especially DNA, are investigated as alternatives to silicon-based computer technologies. One is to use DNA as a storage medium, and the other is to use DNA for computing. Both strategies come with certain constraints. In the current study, we present a novel approach derived from chaos game representation for DNA to generate DNA code words that fulfill user-defined constraints, namely GC content, homopolymers, and undesired motifs, and thus, can be used to build codes for reliable DNA storage systems.Entities:
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Year: 2022 PMID： 34908135 PMCID： PMC8934655 DOI： 10.1093/nar/gkab1209
Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971