AIMS: To test the hypothesis that spinal cord stimulation (SCS) acutely improves heart rate variability (HRV) and baroreceptor sensitivity (BRS) in patients with heart failure (HF). METHODS: SCS (15 minutes) was delivered in four different settings: 90% of maximal tolerated stimulation amplitude (MTA) targeting the T1-T4 spinal cord segments (SCS90T1-4), 60% of MTA (SCS60T1-4), 90% of MTA with cranial (SCS90CR) and caudal (SCS90CA) electrode configuration. HRV and BRS were recorded continuously and stimulation was compared to device off. RESULTS: Fifteen HF patients were included. SCS90T1-4 did not change the standard deviation of intervals between normal beats (SDNN, p = 0.90), BRS (p = 0.55) or other HRV parameters. In patients with baseline SDNN <50 ms, SCS90T1-4 significantly increased SDNN (p = 0.004). CONCLUSIONS: Acute SCS at 60-90% of MTA targeting upper thoracic spinal cord segments does not improve autonomic balance or baroreceptor sensitivity in unselected patients with heart failure but may improve HRV in patients with low SDNN.
AIMS: To test the hypothesis that spinal cord stimulation (SCS) acutely improves heart rate variability (HRV) and baroreceptor sensitivity (BRS) in patients with heart failure (HF). METHODS: SCS (15 minutes) was delivered in four different settings: 90% of maximal tolerated stimulation amplitude (MTA) targeting the T1-T4 spinal cord segments (SCS90T1-4), 60% of MTA (SCS60T1-4), 90% of MTA with cranial (SCS90CR) and caudal (SCS90CA) electrode configuration. HRV and BRS were recorded continuously and stimulation was compared to device off. RESULTS: Fifteen HF patients were included. SCS90T1-4 did not change the standard deviation of intervals between normal beats (SDNN, p = 0.90), BRS (p = 0.55) or other HRV parameters. In patients with baseline SDNN <50 ms, SCS90T1-4 significantly increased SDNN (p = 0.004). CONCLUSIONS: Acute SCS at 60-90% of MTA targeting upper thoracic spinal cord segments does not improve autonomic balance or baroreceptor sensitivity in unselected patients with heart failure but may improve HRV in patients with low SDNN.
Authors: Ziad F Issa; Xiaohong Zhou; Michael R Ujhelyi; Josh Rosenberger; Deepak Bhakta; William J Groh; John M Miller; Douglas P Zipes Journal: Circulation Date: 2005-06-13 Impact factor: 29.690
Authors: Scott A Bernstein; Brian Wong; Carolina Vasquez; Stuart P Rosenberg; Ryan Rooke; Laura M Kuznekoff; Joshua M Lader; Vanessa M Mahoney; Tatyana Budylin; Marie Älvstrand; Tammy Rakowski-Anderson; Rupinder Bharmi; Riddhi Shah; Steven Fowler; Douglas Holmes; Taraneh G Farazi; Larry A Chinitz; Gregory E Morley Journal: Heart Rhythm Date: 2012-05-01 Impact factor: 6.343
Authors: R D Foreman; B Linderoth; J L Ardell; K W Barron; M J Chandler; S S Hull; G J TerHorst; M J DeJongste; J A Armour Journal: Cardiovasc Res Date: 2000-08 Impact factor: 10.787
Authors: René Cardinal; Jeffrey L Ardell; Bengt Linderoth; Michel Vermeulen; Robert D Foreman; J Andrew Armour Journal: Auton Neurosci Date: 2004-03-31 Impact factor: 3.145