| Literature DB >> 3490491 |
J E Alouf, C Geoffroy, D Klatzmann, J C Gluckman, J Gruest, L Montagnier.
Abstract
Purified streptococcal mitogens (SMs) including erythrogenic exotoxin were compared with phytohemagglutinin (PHA) for their ability to sustain lymphadenopathy-associated virus (LAV) replication after the stimulation of normal human peripheral blood mononuclear cells and purified CD4+ and CD8+ T cells infected with LAV. Both SM and PHA supported LAV production in peripheral blood mononuclear and CD4+ cells but not in CD8+ cells. LAV production assessed by the assay of reverse transcriptase in cell supernatants appeared earlier after stimulation with SM and was 6- to 10-fold greater than after stimulation by PHA.Entities:
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Year: 1986 PMID: 3490491 PMCID: PMC268988 DOI: 10.1128/jcm.24.4.639-641.1986
Source DB: PubMed Journal: J Clin Microbiol ISSN: 0095-1137 Impact factor: 5.948