Literature DB >> 34902144

Mass Spectrometry Imaging of Metabolites by Nanostructure Initiator Mass Spectrometry with Fluorinated Gold Nanoparticles.

Amelia Palermo1.   

Abstract

Nanostructure initiator mass spectrometry (NIMS) with fluorinated gold nanoparticles (f-AuNPs) enables the detection and spatial localization of a breath of polar metabolites and lipids with high spatial resolution and ultrasensitivity. Here we describe the methods and procedures for the synthesis and application of f-AuNPs for NIMS of small molecule metabolites and lipids in biological tissues, encompassing sample preparation, mass spectrometric detection, and data analysis and interpretation.
© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Gold nanoparticles; Mass spectrometry imaging; Metabolism heterogeneity; Metabolite imaging; Metabolomics; Nanostructure initiator mass spectrometry

Mesh：

Substances：

Year:  2022        PMID： 34902144     DOI： 10.1007/978-1-0716-2030-4_8

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  18 in total

1.  An activated carbon substrate surface for laser desorption mass spectrometry

Authors: 
Journal:  J Am Soc Mass Spectrom       Date:  2000-07       Impact factor: 3.109

Review 2.  Nanostructure imaging mass spectrometry: the role of fluorocarbons in metabolite analysis and yoctomole level sensitivity.

Authors:  Michael E Kurczy; Trent R Northen; Sunia A Trauger; Gary Siuzdak
Journal:  Methods Mol Biol       Date:  2015

Review 3.  Nanostructure-initiator mass spectrometry metabolite analysis and imaging.

Authors:  Matthew P Greving; Gary J Patti; Gary Siuzdak
Journal:  Anal Chem       Date:  2010-11-04       Impact factor: 6.986

4.  Charting Metabolism Heterogeneity by Nanostructure Imaging Mass Spectrometry: From Biological Systems to Subcellular Functions.

Authors:  Amelia Palermo
Journal:  J Am Soc Mass Spectrom       Date:  2020-08-10       Impact factor: 3.109

5.  Perspective on Advances in Laser-Based High-Resolution Mass Spectrometry Imaging.

Authors:  Tongtong Wang; Xiaoling Cheng; Hexin Xu; Yifan Meng; Zhibin Yin; Xiaoping Li; Wei Hang
Journal:  Anal Chem       Date:  2019-12-09       Impact factor: 6.986

6.  Desorption/ionization on silicon nanowires.

Authors:  E P Go; J V Apon; G Luo; A Saghatelian; R H Daniels; V Sahi; R Dubrow; B F Cravatt; A Vertes; G Siuzdak
Journal:  Anal Chem       Date:  2005-03-15       Impact factor: 6.986

7.  Nanophotonic ion production from silicon microcolumn arrays.

Authors:  Bennett N Walker; Trust Razunguzwa; Matthew Powell; Richard Knochenmuss; Akos Vertes
Journal:  Angew Chem Int Ed Engl       Date:  2009       Impact factor: 15.336

8.  Ion desorption efficiency and internal energy transfer in carbon-based surface-assisted laser desorption/ionization mass spectrometry: desorption mechanism(s) and the design of SALDI substrates.

Authors:  Ho-Wai Tang; Kwan-Ming Ng; Wei Lu; Chi-Ming Che
Journal:  Anal Chem       Date:  2009-06-15       Impact factor: 6.986

9.  Clathrate nanostructures for mass spectrometry.

Authors:  Trent R Northen; Oscar Yanes; Michael T Northen; Dena Marrinucci; Winnie Uritboonthai; Junefredo Apon; Stephen L Golledge; Anders Nordström; Gary Siuzdak
Journal:  Nature       Date:  2007-10-25       Impact factor: 49.962

10.  Fluorinated Gold Nanoparticles for Nanostructure Imaging Mass Spectrometry.

Authors:  Amelia Palermo; Erica M Forsberg; Benedikt Warth; Aries E Aisporna; Elizabeth Billings; Ellen Kuang; H Paul Benton; David Berry; Gary Siuzdak
Journal:  ACS Nano       Date:  2018-07-06       Impact factor: 15.881
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