Literature DB >> 34900826

Personalized medicine in cardiovascular disease: review of literature.

Ali Sheikhy1, Aida Fallahzadeh1, Hamid Reza Aghaei Meybodi2, Mandana Hasanzad3,4, Masih Tajdini5, Kaveh Hosseini5.   

Abstract

PURPOSE: Personalized medicine (PM) is the concept of managing patients based on their characteristics, including genotypes. In the field of cardiology, advantages of PM could be found in the diagnosis and treatment of several conditions such as arrhythmias and cardiomyopathies; moreover, it may be beneficial to prevent adverse drug reactions (ADR) and select the best medication. Genetic background can help us in selecting effective treatments, appropriate dose requirements, and preventive strategies in individuals with particular genotypes.
METHOD: In this review, we provide examples of personalized medicine based on human genetics for the most used pharmaceutics in cardiology, including warfarin, clopidogrel, and statins. We also review cardiovascular diseases, including coronary artery disease, arrhythmia, and cardiomyopathies.
CONCLUSION: Genetic factors are as important as environmental factors and they should be tested and evaluated more in the future by improving in genetic testing tools. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40200-021-00840-0. © Springer Nature Switzerland AG 2021.

Entities:  

Keywords:  CVD; Cardiology; Cardiovascular disease; Personalized medicine

Year:  2021        PMID： 34900826      PMCID： PMC8630142          DOI： 10.1007/s40200-021-00840-0

Source DB:  PubMed          Journal:  J Diabetes Metab Disord        ISSN： 2251-6581


  163 in total

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Journal:  Circulation       Date:  1998-11-24       Impact factor: 29.690

Review 2.  Idiopathic Ventricular Fibrillation: The Struggle for Definition, Diagnosis, and Follow-Up.

Authors:  Marloes Visser; Jeroen F van der Heijden; Pieter A Doevendans; Peter Loh; Arthur A Wilde; Rutger J Hassink
Journal:  Circ Arrhythm Electrophysiol       Date:  2016-05

Review 3.  Guidelines for the diagnosis and management of Catecholaminergic Polymorphic Ventricular Tachycardia.

Authors:  Andreas Pflaumer; Andrew M Davis
Journal:  Heart Lung Circ       Date:  2011-11-25       Impact factor: 2.975

4.  Mutation analysis in patients with the typical form of Anderson-Fabry disease.

Authors:  J P Davies; B G Winchester; S Malcolm
Journal:  Hum Mol Genet       Date:  1993-07       Impact factor: 6.150

Review 5.  Clinical pharmacokinetics and pharmacodynamics of clopidogrel.

Authors:  Xi-Ling Jiang; Snehal Samant; Lawrence J Lesko; Stephan Schmidt
Journal:  Clin Pharmacokinet       Date:  2015-02       Impact factor: 6.447

6.  Genetic basis and molecular mechanism for idiopathic ventricular fibrillation.

Authors:  Q Chen; G E Kirsch; D Zhang; R Brugada; J Brugada; P Brugada; D Potenza; A Moya; M Borggrefe; G Breithardt; R Ortiz-Lopez; Z Wang; C Antzelevitch; R E O'Brien; E Schulze-Bahr; M T Keating; J A Towbin; Q Wang
Journal:  Nature       Date:  1998-03-19       Impact factor: 49.962

7.  CETP genotype predicts increased mortality in statin-treated men with proven cardiovascular disease: an adverse pharmacogenetic interaction.

Authors:  Jakub J Regieli; J Wouter Jukema; Diederick E Grobbee; John J P Kastelein; Jan Albert Kuivenhoven; Aeilko H Zwinderman; Yolanda van der Graaf; Michiel L Bots; Pieter A Doevendans
Journal:  Eur Heart J       Date:  2008-10-28       Impact factor: 29.983

8.  Large-scale association analysis identifies new risk loci for coronary artery disease.

Authors:  Panos Deloukas; Stavroula Kanoni; Christina Willenborg; Martin Farrall; Themistocles L Assimes; John R Thompson; Erik Ingelsson; Danish Saleheen; Jeanette Erdmann; Benjamin A Goldstein; Kathleen Stirrups; Inke R König; Jean-Baptiste Cazier; Asa Johansson; Alistair S Hall; Jong-Young Lee; Cristen J Willer; John C Chambers; Tõnu Esko; Lasse Folkersen; Anuj Goel; Elin Grundberg; Aki S Havulinna; Weang K Ho; Jemma C Hopewell; Niclas Eriksson; Marcus E Kleber; Kati Kristiansson; Per Lundmark; Leo-Pekka Lyytikäinen; Suzanne Rafelt; Dmitry Shungin; Rona J Strawbridge; Gudmar Thorleifsson; Emmi Tikkanen; Natalie Van Zuydam; Benjamin F Voight; Lindsay L Waite; Weihua Zhang; Andreas Ziegler; Devin Absher; David Altshuler; Anthony J Balmforth; Inês Barroso; Peter S Braund; Christof Burgdorf; Simone Claudi-Boehm; David Cox; Maria Dimitriou; Ron Do; Alex S F Doney; NourEddine El Mokhtari; Per Eriksson; Krista Fischer; Pierre Fontanillas; Anders Franco-Cereceda; Bruna Gigante; Leif Groop; Stefan Gustafsson; Jörg Hager; Göran Hallmans; Bok-Ghee Han; Sarah E Hunt; Hyun M Kang; Thomas Illig; Thorsten Kessler; Joshua W Knowles; Genovefa Kolovou; Johanna Kuusisto; Claudia Langenberg; Cordelia Langford; Karin Leander; Marja-Liisa Lokki; Anders Lundmark; Mark I McCarthy; Christa Meisinger; Olle Melander; Evelin Mihailov; Seraya Maouche; Andrew D Morris; Martina Müller-Nurasyid; Kjell Nikus; John F Peden; N William Rayner; Asif Rasheed; Silke Rosinger; Diana Rubin; Moritz P Rumpf; Arne Schäfer; Mohan Sivananthan; Ci Song; Alexandre F R Stewart; Sian-Tsung Tan; Gudmundur Thorgeirsson; C Ellen van der Schoot; Peter J Wagner; George A Wells; Philipp S Wild; Tsun-Po Yang; Philippe Amouyel; Dominique Arveiler; Hanneke Basart; Michael Boehnke; Eric Boerwinkle; Paolo Brambilla; Francois Cambien; Adrienne L Cupples; Ulf de Faire; Abbas Dehghan; Patrick Diemert; Stephen E Epstein; Alun Evans; Marco M Ferrario; Jean Ferrières; Dominique Gauguier; Alan S Go; Alison H Goodall; Villi Gudnason; Stanley L Hazen; Hilma Holm; Carlos Iribarren; Yangsoo Jang; Mika Kähönen; Frank Kee; Hyo-Soo Kim; Norman Klopp; Wolfgang Koenig; Wolfgang Kratzer; Kari Kuulasmaa; Markku Laakso; Reijo Laaksonen; Ji-Young Lee; Lars Lind; Willem H Ouwehand; Sarah Parish; Jeong E Park; Nancy L Pedersen; Annette Peters; Thomas Quertermous; Daniel J Rader; Veikko Salomaa; Eric Schadt; Svati H Shah; Juha Sinisalo; Klaus Stark; Kari Stefansson; David-Alexandre Trégouët; Jarmo Virtamo; Lars Wallentin; Nicholas Wareham; Martina E Zimmermann; Markku S Nieminen; Christian Hengstenberg; Manjinder S Sandhu; Tomi Pastinen; Ann-Christine Syvänen; G Kees Hovingh; George Dedoussis; Paul W Franks; Terho Lehtimäki; Andres Metspalu; Pierre A Zalloua; Agneta Siegbahn; Stefan Schreiber; Samuli Ripatti; Stefan S Blankenberg; Markus Perola; Robert Clarke; Bernhard O Boehm; Christopher O'Donnell; Muredach P Reilly; Winfried März; Rory Collins; Sekar Kathiresan; Anders Hamsten; Jaspal S Kooner; Unnur Thorsteinsdottir; John Danesh; Colin N A Palmer; Robert Roberts; Hugh Watkins; Heribert Schunkert; Nilesh J Samani
Journal:  Nat Genet       Date:  2012-12-02       Impact factor: 38.330

9.  European Society of Cardiology: Cardiovascular Disease Statistics 2017.

Authors:  Adam Timmis; Nick Townsend; Chris Gale; Rick Grobbee; Nikos Maniadakis; Marcus Flather; Elizabeth Wilkins; Lucy Wright; Rimke Vos; Jeroen Bax; Maxim Blum; Fausto Pinto; Panos Vardas
Journal:  Eur Heart J       Date:  2018-02-14       Impact factor: 29.983

10.  Influence of CYP4F2, ApoE, and CYP2A6 gene polymorphisms on the variability of Warfarin dosage requirements and susceptibility to cardiovascular disease in Jordan.

Authors:  Laith N Al-Eitan; Ayah Y Almasri; Adan H Alnaamneh; Hatem A Aman; Nasr N Alrabadi; Rame H Khasawneh; Mansour A Alghamdi
Journal:  Int J Med Sci       Date:  2021-01-01       Impact factor: 3.738
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