Literature DB >> 3489673

Further definition of the Ly-5 system.

F W Shen, J S Tung, E A Boyse.   

Abstract

Ly-5 is expressed by cells of the hematopoietic branch of development. Further serological analysis of the Ly-5 system, aided by Ly-5 monoclonal antibodies and by two Ly-5 congenic mouse strains, reveals two new Ly-5 alloantigens, Ly-5.3 and Ly-5.4. The data define three thymocyte phenotypes, Ly-5.1,3, Ly-5.2,4, and Ly-5.2,3, and three corresponding genotypes, Ly-5a, Ly-5b, and Ly-5c, respectively. Ly-5a is by far the most common allele. The Ly-5c allele is found only in the ST/bJ strain, a finding that accords with the presently unique pattern of restriction fragments previously observed in Southern blotting of ST/bJ DNA with an Ly-5 cDNA probe. Present serological and biochemical data favor the interpretation that the compound Ly-5 phenotype of thymocytes is attributable to two separate Ly-5 molecular isoforms that exhibit a discrete difference in protein composition, bear different Ly-5 antigens, and are produced jointly by thymocytes, unlike other Ly-5 isoforms previously shown to distinguish different hematopoietic cell lineages.

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Year:  1986        PMID： 3489673     DOI： 10.1007/BF00364741

Source DB:  PubMed          Journal:  Immunogenetics        ISSN： 0093-7711            Impact factor:   2.846


  5 in total

1.  Different forms of Ly-5 within the T-cell lineage.

Authors:  J S Tung; M P Scheid; M A Palladino
Journal:  Immunogenetics       Date:  1983       Impact factor: 2.846

2.  Evidence that Ly-5 product of T and B cells differ in protein structure.

Authors:  J S Tung; M C Deere; E A Boyse
Journal:  Immunogenetics       Date:  1984       Impact factor: 2.846

3.  An alloantigen selective for B cells: Ly-17.1.

Authors:  F W Shen; E A Boyse
Journal:  Immunogenetics       Date:  1980       Impact factor: 2.846

4.  Structural features and selective expression of three Ly-5+ cell-surface molecules.

Authors:  J S Tung; M P Scheid; M A Pierotti; U Hämmerling; E A Boyse
Journal:  Immunogenetics       Date:  1981       Impact factor: 2.846

5.  Cloning of Ly-5 cDNA.

Authors:  F W Shen; Y Saga; G Litman; G Freeman; J S Tung; H Cantor; E A Boyse
Journal:  Proc Natl Acad Sci U S A       Date:  1985-11       Impact factor: 11.205
  5 in total
  10 in total

Review 1.  The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases.

Authors:  Irving L Weissman; Judith A Shizuru
Journal:  Blood       Date:  2008-11-01       Impact factor: 22.113

2.  Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice.

Authors:  D E Zhang; P Zhang; N D Wang; C J Hetherington; G J Darlington; D G Tenen
Journal:  Proc Natl Acad Sci U S A       Date:  1997-01-21       Impact factor: 11.205

3.  Alternative use of 5' exons in the specification of Ly-5 isoforms distinguishing hematopoietic cell lineages.

Authors:  Y Saga; J S Tung; F W Shen; E A Boyse
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

4.  Ly-33: a new lymphocyte alloantigen controlled by a gene linked to Ly-17 locus on mouse chromosome 1.

Authors:  S Kimura; N Tada; J Furze; H Festenstein
Journal:  Immunogenetics       Date:  1987       Impact factor: 2.846

5.  High sequence conservation between rat (T200) and mouse (Ly-5) leukocyte common antigens.

Authors:  L J Gonez; I D Walker; M S Sandrin; I F McKenzie
Journal:  Immunogenetics       Date:  1987       Impact factor: 2.846

6.  A role for TGFbeta1 in langerhans cell biology. Further characterization of the epidermal Langerhans cell defect in TGFbeta1 null mice.

Authors:  T A Borkowski; J J Letterio; C L Mackall; A Saitoh; X J Wang; D R Roop; R E Gress; M C Udey
Journal:  J Clin Invest       Date:  1997-08-01       Impact factor: 14.808

7.  CD43-mediated IFN-γ production by CD8+ T cells promotes abdominal aortic aneurysm in mice.

Authors:  Hui-fang Zhou; Huimin Yan; Judy L Cannon; Luke E Springer; Jonathan M Green; Christine T N Pham
Journal:  J Immunol       Date:  2013-04-12       Impact factor: 5.422

8.  Allelic variants of Ly-5 in inbred and natural populations of mice.

Authors:  M F Seldin; L A D'Hoostelaere; A D Steinberg; Y Saga; H C Morse
Journal:  Immunogenetics       Date:  1987       Impact factor: 2.846

9.  Organization of the Ly-5 gene.

Authors:  Y Saga; J S Tung; F W Shen; T C Pancoast; E A Boyse
Journal:  Mol Cell Biol       Date:  1988-11       Impact factor: 4.272

10.  Challenging cytokine redundancy: inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient, but not tumor necrosis factor-deficient, mice.

Authors:  D Sean Riminton; H Körner; D H Strickland; F A Lemckert; J D Pollard; J D Sedgwick
Journal:  J Exp Med       Date:  1998-05-04       Impact factor: 14.307
  10 in total

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